Prognostic Relevance of Gene-Environment Interactions in Patients With Dilated Cardiomyopathy

Abstract

The MOGE(S) classification in DCM is applicable, and each attribute or the gene-environment interaction is associated with outcome. Importantly, the presence of multiple attributes was a strong predictor of adverse outcome. Finally, adaptation of the MOGE(S) involving multiple possible etiologies is recommended.

Genetic causes of dilated cardiomyopathy

“…The use is supported by a free app downloadable from Google Play Store (Android) or Apple Store (iPhone). The system can be used for both annotation85 and prognostic applications86 and is flexible enough to accommodate clinical and genetic data in large repositories.…”

New Management Strategies in Heart Failure

“…126 Although cumbersome at first glance, this scheme incorporates not only the standard morphofunctional attributes of cardiomyopathy but also the increasingly important pathologic (genetic, environmental, etc) and spectrum of functional status, including preclinical disease (genotype positive and phenotype negative). A classification scheme that provides a common language among clinicians and scientists promotes collaboration and discovery, as illustrated in a recent study by Hazebroek et al 127 An important example highlighting the need for deep phenotyping is the rapidly unfolding pathophysiology of arrhythmogenic right ventricular cardiomyopathy (ARVC). The presence of cardiotropic viruses was documented in patients with ARVC by Bowles et al 128 in 2002; however, the pathophysiologic role was unknown.…”

Classification of Non-Coronary Heart Diseases. Point of View

“…Ее главным достоинством нам представляются полнота описания всех возможных проявлений НКЗМ у конкретного больного, возможность отражения в диагнозе смешанных форм, которая до сих не предус-матривалась ни одной классификацией. Уже получены данные о неблагоприятном прогностическом значении наличия у одного пациента множественных атрибутов MOGE(S) [12]. Остается пожелать, чтобы классифика-ция MOGE(S) стала практическим и научным прило-жением к более простой и фундаментальной классифи-кации, построенной по нозологическому принципу.…”