Prognostic Relevance of Liver Stiffness Assessed by Transient Elastography in Patients With Acute Decompensated Heart Failure

Saito, Yuki; Kato, Masashi; Nagashima, Koichi; Monno, Koyuru; Aizawa, Yoshihiro; Okumura, Yasuo; Matsumoto, Naoki; Moriyama, Mitsuhiko; Hirayama, Atsushi

doi:10.1253/circj.cj-17-1344

Cited by 57 publications

(69 citation statements)

References 32 publications

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“…Because the number of patients with liver cirrhosis was relatively small in the present study and we have included it in multivariable analyses, liver cirrhosis has not dramatically influenced the results of the study. However, it is very important to investigate the potential presence of liver dysfunction by blood tests 33 and imaging modalities such as computed tomography, abdominal ultrasound, and transient elastography 34 when the CONUT score of a given patient with ADHF is high. The onset of liver cirrhosis is characterized by low albumin and platelet levels and spleen enlargement.…”

Section: Discussionmentioning

confidence: 99%

Association with Controlling Nutritional Status (CONUT) Score and In-hospital Mortality and Infection in Acute Heart Failure

Kato

Yaku

Morimoto

et al. 2020

Sci Rep

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the high controlling nutritional status (conUt) score that represents poor nutritional status has been acknowledged to have prognostic implications in chronic heart failure. We aimed to investigate its role in acute decompensated heart failure (ADHf). Using the data from an multicenter registry that enrolled 4056 consecutive patients hospitalized for ADHF in Japan between 2014 and 2016, we analyzed 2466 patients in whom data on the components of the conUt score at hospital presentation were available. The decrease of lymphocyte count and total cholesterol was assigned with 0, 1, 2, and 3 points and the decrease of albumin was assigned with 0, 2, 4, and 6 points according to the severity. We defined low CONUT score as 0-4 (N = 1568) and high CONUT score as 5-9 (N = 898). The patients in the high CONUT score group were older and more likely to have a smaller body mass index than those in the low conUt score group. the high conUt score group was associated with higher rate of death and infection during the index hospitalization compared to the low CONUT score group (9.0% versus 4.4%, and 21.9% versus 12.7%, respectively). After adjusting for confounders, the excess risk of high relative to low CONUT score for mortality and infection was significant (OR: 1.61, 95%CI: 1.05-2.44, and OR: 1.66, 95%CI: 1.30-2.12, respectively). The effect was incremental according to the score. High CONUT score was associated with higher risk for in-hospital mortality and infection in an incremental manner in patients hospitalized for ADHf. Despite recent advances in chronic heart failure (HF) therapy, there remain unmet needs to reduce the high mortality rate and to assess the mortality risk in patients hospitalized for acute decompensated HF (ADHF) 1 .

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Section: Discussionmentioning

confidence: 99%

Association with Controlling Nutritional Status (CONUT) Score and In-hospital Mortality and Infection in Acute Heart Failure

Kato

Yaku

Morimoto

et al. 2020

Sci Rep

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“…[3][4][5][6][7] In the field of adult cardiology, liver stiffness is known to reflect central venous pressure (CVP). [8][9][10][11][12] In patients after the Fontan procedure, SWE of the liver is reportedly useful for identifying hepatic fibrosis. [13][14][15] However, the association between SWE findings of the liver and CVP among children with heart diseases has not been clarified.…”

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confidence: 99%

Usefulness of Liver Stiffness on Ultrasound Shear-Wave Elastography for the Evaluation of Central Venous Pressure in Children With Heart Diseases

Terashi

Kodama

Kuraoka

et al. 2019

Circ J

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“…2,3 Persistently elevated filling pressures or signs and symptoms of congestion at discharge are associated with a poor prognosis in patients with ADHF. 4–6 Recent studies have suggested the use of liver stiffness as a non-invasive surrogate marker of central venous pressure to offer additional prognostic information in patients hospitalized with ADHF. 2,4,7,8 However, the available data are limited by small studies.…”

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confidence: 99%

“…4–6 Recent studies have suggested the use of liver stiffness as a non-invasive surrogate marker of central venous pressure to offer additional prognostic information in patients hospitalized with ADHF. 2,4,7,8 However, the available data are limited by small studies. Therefore, the primary objective of this systematic review and meta-analysis was to evaluate the association of liver stiffness and cardiovascular outcomes in hospitalized heart failure patients.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Association of liver stiffness and cardiovascular outcomes in patients with heart failure: A systematic review and meta-analysis

Khan

Siddiqi

Khan

et al. 2018

Eur J Prev Cardiolog

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Prognostic Relevance of Liver Stiffness Assessed by Transient Elastography in Patients With Acute Decompensated Heart Failure

Cited by 57 publications

References 32 publications

Association with Controlling Nutritional Status (CONUT) Score and In-hospital Mortality and Infection in Acute Heart Failure

Association with Controlling Nutritional Status (CONUT) Score and In-hospital Mortality and Infection in Acute Heart Failure

Usefulness of Liver Stiffness on Ultrasound Shear-Wave Elastography for the Evaluation of Central Venous Pressure in Children With Heart Diseases

Association of liver stiffness and cardiovascular outcomes in patients with heart failure: A systematic review and meta-analysis

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