Prognostic relevance of the expression of Tdt and CD7 in 335 cases of acute myeloid leukemia

Venditti, Adriano; Poeta, Giovanni Del; Buccisano, Francesco; Tamburini, Anna; Cox-Froncillo, M. Christina; Aronica, G; Bruno, Antonio; Moro, Beatrice Del; Epiceno, Anna Maria; Battaglia, Alessandra; Forte, Laura; Postorino, Massimiliano; Cordero, V. Ruiz; Santinelli, S; Amadori, Sergio

doi:10.1038/sj.leu.2401067

Cited by 88 publications

(70 citation statements)

References 36 publications

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“…In our cases, there was a statistical significant relation between CD7aberrant expression and unfavorable cytogenetic pattern (p=0.046), in agreement with Ogata et al (2001) who found that the proportion of CD7+cases increased stepwise from the cases with favorable cytogenetics to the cases with intermediate and unfavorable cytogenetics, we support their recommendation that CD7 expression in AML should be interpreted in association with the cytogenetic. No statistical significance could be detected between CD7+AML and CD7-AML regarding CR or OS (p=0.68, 0.07 respectively) in agreement with Chang et al, (2007) but in contrast with Venditti et al, (1998) who reported that CD7 expression in AML adversely affect achievement of CR (p=0.013) and associated with shorter OS (p=0.006). This contradiction in the prognostic value of CD7in AML may be related to the fact that the cytogenetics status of the study population significantly skews the results where CD7 expression had no prognostic value if most examined cases had intermediate cytogenetics, while CD7+cases with unfavorable cytogenetics had an extremely poor prognosis (Ogata et al, 2001).…”

Section: 221 Clinical Significance Of Aberrant Antigens In Acute Leumentioning

confidence: 83%

“…Aberrant antigen expression is reported to have variable frequency (Voskova et al, 2003;Vitale et al 2007;Zhang et al, 2012;Novoa et al, 2013) most commonly CD7 (Chang et al, 2007), CD9, CD19 and CD56 in AML cases (El-Sissy et al, 2006) as well as CD13 and CD33 in ALL (Liu et al, 2007;Suggs et al, 2007) and their prognostic and predictive relevance is controversial (Bhushan et al, 2010). However, several reports discussed their clinical significance, but most of them were not comprehensive (Putti et al, 1998;Venditti et al, 1998;Ogata et al, 2001).…”

Section: Introductionmentioning

confidence: 99%

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Clinical Significance of Co-expression of Aberrant Antigens in Acute Leukemia: A Retrospective Cohort Study in Makah Al Mukaramah, Saudi Arabia

Abdulateef

Ismail²,

Aljedani³

2014

Asian Pacific Journal of Cancer Prevention

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Section: 221 Clinical Significance Of Aberrant Antigens In Acute Leumentioning

confidence: 83%

Section: Introductionmentioning

confidence: 99%

Clinical Significance of Co-expression of Aberrant Antigens in Acute Leukemia: A Retrospective Cohort Study in Makah Al Mukaramah, Saudi Arabia

Abdulateef

Ismail²,

Aljedani³

2014

Asian Pacific Journal of Cancer Prevention

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“…The particular marker combination was chosen because it is 1) widely used, 2) allows for an easy quantification of the marker expression on AML blasts and 3) was continuously used throughout the study period. Although TdT might be considered an unusual marker for AML, its correlation with blast immaturity is particularly strong [17].…”

Section: Discussionmentioning

confidence: 99%

Flow cytometric maturity score as a novel prognostic parameter in patients with acute myeloid leukemia

et al. 2015

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Abstract:The European LeukemiaNet (ELN) classification is widely accepted for risk stratification of patients with acute myeloid leukemia (AML). In order to establish immunophenotypic features that predict prognosis, the expression of single AML blast cell antigens has been evaluated with partly conflicting results; however, the influence of immunophenotypic blast maturity is largely unknown.In our study, 300 AML patients diagnosed at our institution between 01/2003 and 04/2012 were analyzed. A flow cytometric maturity score was developed in order to distinguish "mature" AML (AML-ma) from "immature" AML (AML-im) by quantitative expression levels of early progenitor cell antigens (CD34, CD117, and TdT).AML-ma showed significantly longer relapse-free survival (RFS) and overall survival (OS) than AML-im (p<0.001). Interestingly, statistically significant differences in RFS and OS were maintained within the Our novel flow cytometric score easily determines AML blast maturity and can predict clinical outcome. It remains to be clarified whether these results simply reflect an accumulation of favorable molecular phenotypes in the AML-ma subgroup or whether they rely on biological differences such as a higher proportion of leukemia stem cells and/or a higher degree of genetic instability within the AML-im subgroup.

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“…Furthermore, AML patients with favorable cytogenetics [t(8;21), t(15;17), or inv(16)] generally expressed CD7 at a significantly lower rate than patients with other cytogenetic abnormalities. However, opposing opinions have also been approached by other researchers (10,12,13), highlighting the importance to perform more comprehensive studies in the future.…”

Section: Discussionmentioning

confidence: 99%

A correlation study of immunophenotypic, cytogenetic, and clinical features of 180 AML patients in China

Zheng

Wang

et al. 2007

Cytometry Part B Clinical

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New WHO classification has been widely applied in the diagnosis of leukemia. To elucidate the immunophenotype of acute myeloid leukemia (AML) and characterize the correlation among morphological, immunological, cytogenetic, and clinical features, we studied the bone marrow immunophenotypes of 180 AML patients in China by flow cytometry. The results showed that CD34, CD2, CD14, CD19, CD56, and HLA-DR were correlated with FAB subtypes. Amongst the 180 patients enrolled in this study, 122 cases were also subjected to karyotype analysis by G-banding technology and abnormal karyotypes were detected in 69 out of 122 patients. Correlation assay showed that t(8;21) was only present in 16 AML-M2 patients, and strongly associated with the individual or combinational expressions of CD15/CD19/CD34/CD56. As to M3, although lymphoid lineage antigens were observed in a considerable number of patients, they were never detected in t(15;17) positive patients. The expressions of CD22, CD56, and TdT showed significant correlation with the overall presence of abnormal karyotype. Additionally, the expressions of CD4, CD7, CD14, CD56, and TdT were positively correlated with clinical features such as white blood cell count, platelet count, and patient's age. In conclusion, immunophenotype analysis was useful for AML diagnosis and classification. At the same time, the data also suggested that the karyotype abnormalities and clinical features were tightly linked with abnormal antigen expression characteristics in AML patients. As one of the largest correlative study performed in China, the results highlighted the importance of a morphological, immunological, and cytogenetic classification of AML that might constitute a working basis for future studies aimed at a better definition of clinicopathological features and optimal treatment strategy for these leukemias. q 2007 Clinical Cytometry Society

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Prognostic relevance of the expression of Tdt and CD7 in 335 cases of acute myeloid leukemia

Abstract: We conclude that the expression of Tdt or CD7 is associated with an unfavorable outcome and that the combination of both defines a clinical subset with a poorer prognosis due to the significantly higher association with MDR phenotype, and 'poor prognostic' chromosomal abnormalities.

Cited by 88 publications

References 36 publications

Clinical Significance of Co-expression of Aberrant Antigens in Acute Leukemia: A Retrospective Cohort Study in Makah Al Mukaramah, Saudi Arabia

Clinical Significance of Co-expression of Aberrant Antigens in Acute Leukemia: A Retrospective Cohort Study in Makah Al Mukaramah, Saudi Arabia

Flow cytometric maturity score as a novel prognostic parameter in patients with acute myeloid leukemia

A correlation study of immunophenotypic, cytogenetic, and clinical features of 180 AML patients in China

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