Prognostic Relevance of Ww-Oxidoreductase Gene Expression in Patients with Acute Lymphoblastic Leukemia

Elbossaty, Walaa Fikry; M.Elghanam, Doaa

doi:10.4172/1948-5956.1000367

Cited by 3 publications

(3 citation statements)

References 18 publications

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“…At the cellular level, acute leukemia's are rapidly progressing diseases, which characterized with over growth of immature malignant cell and this lead to decrease synthesis of mature normal blood cell due to suppression of hematopoiesis and this lead to anemia, thrombocytopenia, and hyperleukocytosis, all of this lead to fever, fatigue, infection, and bleeding [8] . Continuously divided and overproduced of immature cells in the bone marrow caused damage in some organs due to spreading (infiltrating) of blasts cells to other organs [9] .…”

Section: Discussionmentioning

confidence: 99%

Study of Liver and Kidney Biochemical Variations in Patients with Various Morphological Types of Leukemia at a Tertiary Healthcare Hospital

Woike¹

2018

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Leukemias are malignant neoplasm of the haematopoietic stem cells, arising in the bone marrow that flood the circulating blood or other organs. The objective of this study was to find out the effect of leukemia on liver and renal function of the patients at our institute. Present study is a prospective study which includes the findings and observations of 25 patients diagnosed with leukemia of various types such as acute lymphoblastic leukemia, acute myeloid leukemia, chronic myeloid leukemia and chronic lymphocytic leukemia. Diagnosis of the patients were made by their peripheral smear examination and various parameters counted by automated haematology analyzer and their confirmation was made by using special stains and bone marrow examination. Liver and renal function tests were performed in the patients and results were observed. In acute myeloid leukemia liver function tests were found altered with mainly rise in serum alkaline and alanine transferase, in acute lymphoblastic leukemia, there was marked increase in alkaline phosphatase with normal or decreased SGOT and SGPT value, in chronic myeloid leukemia increase in uric acid was observed with slight fluctuating values in SGOT/SGPT but no significant changes were seen in patients with chronic lymphocytic leukemia.

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Section: Discussionmentioning

confidence: 99%

Study of Liver and Kidney Biochemical Variations in Patients with Various Morphological Types of Leukemia at a Tertiary Healthcare Hospital

Woike¹

2018

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“…At the cellular level, acute leukemia's are rapidly progressing diseases, which characterized with over growth of immature malignant cell and this lead to decrease synthesis of mature normal blood cell due to suppression of hematopoiesis and this lead to anemia, thrombocytopenia, and hyperleukocytosis, all of this lead to fever, fatigue, infection, and bleeding [9]. Continuously divided and overproduced of immature cells in the bone marrow caused damage in some organs due to spreading (infiltrating) of blasts cells to other organs [10].…”

Section: Discussionmentioning

confidence: 99%

Acute Renal and Hepatic Failure and Abnormal Blood Cell Count in Acute Leukemia: A Report of Four Cases and Review of the Literature

Elbossaty¹

2017

J Pharma Care Health Sys

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Leukemia is white blood cells cancer, which characterized with production of immature blood cells. Overcrowding of bone marrow with this abnormal immature cells, which interference with normal blood cells production, this may be lead to hyperleukocytosis, cytopenias, liver and kidney failure. In this study reports a case series of four patients with acute leukemia were studied. From this study, we concluded that hyperleukocytosis and cytopenias, disturbance in liver and kidney function were correlated with ALL than in AML.

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“…Indeed, loss of WWOX protein in acute lymphoblastic leukemia (ALL) patients is due to promoter hypermethylation of WWOX gene. 120,121 FHIT and p73 genes are also hypermethylated in ALL. Restoration of WWOX gene reduces leukemic tumorigenesis.…”

Section: Wwox In Forced T-cell Maturation Via a Novel Iκbα/wwox/erk Smentioning

confidence: 99%

Phosphorylation/de-phosphorylation in specific sites of tumor suppressor WWOX and control of distinct biological events

Huang

Chang

2018

Exp Biol Med (Maywood)

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Abnormal differentiation and growth of hematopoietic stem cells cause the development of hematopoietic diseases and hematopoietic malignancies. However, the molecular events underlying leukemia development are not well understood. In our recent study, we have demonstrated that calcium ionophore and phorbol ester force the differentiation of T lymphoblastic leukemia. The event involves a newly identified IκBα/WWOX/ERK signaling, in which WWOX is Ser14 phosphorylated. Additional evidence also reveals that pS14-WWOX is involved in enhancing cancer progression and metastasis and facilitating neurodegeneration. In this mini-review, we update the current knowledge for the functional roles of WWOX under physiological and pathological settings, and provide new insights regarding pS14-WWOX in T leukemia cell maturation, and switching the anticancer pY33-WWOX to pS14-WWOX for cancer promotion and disease progression. Impact statement WWOX was originally designated as a tumor suppressor. However, human newborns deficient in WWOX do not spontaneously develop tumors. Activated WWOX with Tyr33 phosphorylation is present in normal tissues and organs. However, when pY33-WWOX is overly induced under stress conditions, it becomes apoptotic to eliminate damaged cells. Notably, WWOX with Ser14 phosphorylation is upregulated in the lesions of cancer, as well as in the brain hippocampus and cortex with Alzheimer's disease. Suppression of pS14-WWOX by Zfra reduces cancer growth and mitigates Alzheimer's disease progression, suggesting that pS14-WWOX facilitates disease progression. pS14-WWOX can be regarded as a marker of disease progression.

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Prognostic Relevance of Ww-Oxidoreductase Gene Expression in Patients with Acute Lymphoblastic Leukemia

Cited by 3 publications

References 18 publications

Study of Liver and Kidney Biochemical Variations in Patients with Various Morphological Types of Leukemia at a Tertiary Healthcare Hospital

Study of Liver and Kidney Biochemical Variations in Patients with Various Morphological Types of Leukemia at a Tertiary Healthcare Hospital

Acute Renal and Hepatic Failure and Abnormal Blood Cell Count in Acute Leukemia: A Report of Four Cases and Review of the Literature

Phosphorylation/de-phosphorylation in specific sites of tumor suppressor WWOX and control of distinct biological events

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