Prognostic risk factors associated with esophageal squamous cell carcinoma patients undergoing endoscopic submucosal dissection: a multi-center cohort study

Iwai, Naoharu; Dohi, Osamu; Yamada, Shinya; Harusato, Akihito; Horie, Ryusuke; Yasuda, Takeshi; Yamada, Naotaka; Horii, Yusuke; Majima, Atsushi; Zen, Keika; Kimura, Hiroyuki; Yagi, Nobuaki; Naito, Yuji; Itoh, Yoshito

doi:10.1007/s00464-021-08502-1

Cited by 18 publications

(21 citation statements)

References 34 publications

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“…reported that the Charlson Comorbidity Index, prognostic nutritional index, and the depth of invasion were significantly associated with prognosis. 57 Similarly, a multicenter retrospective cohort study by Nakajo et al. included elderly patients aged >75 years and revealed that Charlson Comorbidity Index ≥ 2 was the only independent risk factor for post‐ESD death (hazard ratio, 7.92; 95% confidence interval, 3.42–18.3; p < 0.001).…”

Section: Long‐term Outcomesmentioning

confidence: 98%

“…Moreover, they reported a favorable 5‐year overall survival and 5‐year disease‐specific survival of 81.6%–96.6% and 99.6%–100%, respectively (Table 1 ). 41 , 45 , 57 , 58 , 59 , 60 In relation to the pathological T1a‐MM/T1b‐SM1 cohort, seven studies reported on positive lymphovascular invasion in 8.7%–25.9% cases. Moreover, the 5‐year overall and disease‐specific survivals were 57.3%–95.6% and 96.9%–98.0%, respectively (Table 2 ).…”

Section: Long‐term Outcomesmentioning

confidence: 99%

“…and Yamashina et al. mentioned that the major cause of death was other‐organ malignancies, such as pharyngeal cancers, lung cancers, and hepatocellular carcinomas, which could be explained by smoking and alcohol consumption as potential carcinogens 57,60 . Moreover, Iwai et al.…”

Section: Long‐term Outcomesmentioning

confidence: 99%

mentioning

confidence: 99%

“…45,[57][58][59][60][61][62] Iwai et al and Yamashina et al mentioned that the major cause of death was other-organ malignancies, such as pharyngeal cancers, lung cancers, and hepatocellular carcinomas, which could be explained by smoking and alcohol consumption as potential carcinogens 57,60. Moreover, Iwai et al reported that the Charlson Comorbidity Index, prognostic nutritional index, and the depth of invasion were significantly associated with prognosis 57. Similarly, a multicenter retrospective cohort study by Nakajo et al included elderly patients aged >75 years and revealed that Charlson Comorbidity Index ≥ 2 was the only independent risk factor for post-ESD death (hazard ratio, 7.92; 95% confidence interval, 3.42-18.3; p < 0.001) 63.…”

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confidence: 99%

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Endoscopic resection of esophageal squamous cell carcinoma: Current indications and treatment outcomes

et al. 2021

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Endoscopic resection (ER) is an alternate minimally invasive treatment for superficial esophageal squamous cell carcinoma (SESCC). We aimed to review the clinical indications and treatment outcomes of ER for SESCC. Endoscopic mucosal resection is relatively easy and efficient for SESCC ≤ 15 mm. In contrast, endoscopic submucosal dissection (ESD) is recommended to achieve en bloc resection for lesions >15 mm, in view of the accurate pathological evaluation. The Japan Gastroenterological Endoscopy Society guidelines recommend ER for non‐circumferential cT1a‐EP/LPM (epithelium/lamina propria mucosae), cT1a‐MM/T1b‐SM1 (muscularis mucosa/superficial submucosa ≤ 200μm) SESCC, and whole‐circumferential T1a‐EP/LPM SESCC ≤ 50 mm (upon implementing preventive measures for stenosis), considering the risk‐benefit balance of ER. It defines pT1a‐EP/LPM without lymphovascular invasion as a curative endoscopic resection. The guidelines recommend additional esophagectomy or chemoradiotherapy for pT1b SESCC or any SESCC, with lymphovascular invasion. However, there is no recommendation for or against the administration of additional treatments for pT1a‐MM without lymphovascular invasion, owing to limited evidence. Researchers have reported on high en bloc and R0 resection rates of ESD, and a randomized controlled trial demonstrated that clip‐line traction‐assisted ESD could significantly reduce the ESD procedural time. Moreover, steroid treatment has been developed to prevent post‐ESD esophageal strictures. There have been reports on favorable long‐term outcomes of ESD. However, most of them are retrospective studies. Further robust data in prospective trials are warranted to achieve a definitive evidence of ESD, which will be beneficial to patients with SESCC.

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Section: Long‐term Outcomesmentioning

confidence: 98%

Section: Long‐term Outcomesmentioning

confidence: 99%

Section: Long‐term Outcomesmentioning

confidence: 99%

mentioning

confidence: 99%

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confidence: 99%

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Endoscopic resection of esophageal squamous cell carcinoma: Current indications and treatment outcomes

et al. 2021

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High incidence of lung cancer death after curative endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma

Tajiri,

Tsujii,

Nishida

et al. 2024

Cancer Medicine

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Background and AimFollowing treatment of superficial esophageal squamous cell carcinoma (ESCC), surveillance for a second primary malignancy (SPM) is necessary. However, detailed evidence regarding the timing and prognosis of SPMs is insufficient. We aimed to clarify the details of SPMs and their effects on patient outcomes.MethodsThis retrospective, multicenter study involved 11 hospitals. Patients with superficial ESCC curatively resected using endoscopic submucosal dissection between May 2005 and December 2012, were included in this study.ResultsThe 5‐year survival rate of 187 patients was 92.6% during a median follow‐up duration of 96.8 months. Thirty‐one patients died, 14 of whom died of SPMs. Compared to patients with SPMs detectable by esophagogastroduodenoscopy (EGD), patients with SPMs detectable only by modalities other than EGD had a significantly higher mortality rate (p < 0.001). Patients with second primary lung cancer (LC) had a high mortality rate (56.3%). Univariate and multivariate analyses showed that multiple Lugol‐voiding lesions (LVLs) tended to be associated with SPMs (p = 0.077, hazard ratio [HR] 4.43, 95% confidence interval [CI]: 0.91–6.50), and metachronous ESCC was an independent risk factor for the incidence of second primary LC (p = 0.037, HR 3.51, 95% CI: 1.08–11.41).ConclusionsSPMs that cannot be detected by EGD, such as LC, must be considered after the curative resection of ESCC. We suggest strict screening by both EGD and computed tomography for patients with multiple LVLs or metachronous ESCC to detect SPMs in their early stages.

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Prediction model of 3-year survival after endoscopic submucosal dissection for early gastric cancer in elderly patients aged ≥ 85 years: EGC-2 model

Toya

Shimada

Hamada

et al. 2022

J Cancer Res Clin Oncol

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Prognostic risk factors associated with esophageal squamous cell carcinoma patients undergoing endoscopic submucosal dissection: a multi-center cohort study

Cited by 18 publications

References 34 publications

Endoscopic resection of esophageal squamous cell carcinoma: Current indications and treatment outcomes

Endoscopic resection of esophageal squamous cell carcinoma: Current indications and treatment outcomes

High incidence of lung cancer death after curative endoscopic submucosal dissection for superficial esophageal squamous cell carcinoma

Prediction model of 3-year survival after endoscopic submucosal dissection for early gastric cancer in elderly patients aged ≥ 85 years: EGC-2 model

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