Prognostic Role of 99mTc-HM-PAO-Leukocyte Scintigraphy in Acute Pancreatitis and in Patients with Pancreatic Pseudocysts

PET/CT with 18F-FDG–Labeled Autologous Leukocytes for the Diagnosis of Infected Fluid Collections in Acute Pancreatitis

“…Previous studies in which scintigraphy with radionuclidelabeled leukocytes was used to detect infected pancreatic necrosis were limited to g-camera scintigraphy with leukocytes labeled with 111 In (5,6) or 99m Tc (7)(8)(9)(10). The use of 67 Ga SPECT/CT imaging, with high sensitivity and specificity, was also reported in this clinical context (23).…”

“…However, these studies were limited to g-camera scintigraphy with leukocytes labeled with 111 In (5) or 99m Tc (7)(8)(9)(10), and image quality and resolution were unsatisfactory.…”

Pancreas and Cystic Fibrosis: The Implications of Increased Survival in Cystic Fibrosis

“…Previous attempts have had varying degrees of success [17][18][19]22] . In general, clinical studies have shown a positive relationship between the grade of pancreatic labeled leukocyte uptake and the Glasgow and Ranson scores [17][18][19]22] , and the pancreatic damage observed in CECT [18,19] .…”

“…Previous attempts have had varying degrees of success [17][18][19]22] . In general, clinical studies have shown a positive relationship between the grade of pancreatic labeled leukocyte uptake and the Glasgow and Ranson scores [17][18][19]22] , and the pancreatic damage observed in CECT [18,19] . Furthermore, a positive relationship has been shown between the pancreatic labeled leukocyte uptake and the presence of PN, the plasmatic concentration of elastase granulocitary (a marker of leukocyte activation) and the unfavorable evolution of the illness [19] .…”

“…Several authors have shown the usefulness of scintigraphy using radionuclide-labeled leukocytes, a safe and non-invasive technique, as an indicator of pancreatic damage in patients with AP [17][18][19][20][21][22] . In previous research, we concluded that labeled leukocyte scintigraphy (LLS) may be an alternative to CECT for staging AP [23] .…”