Prognostic role of bioelectrical impedance phase angle for critically ill patients: A systemic review and meta-analysis

Abstract

ObjectiveBioelectrical impedance-derived phase angle (PA) has exhibited good prognostic values in several non-critical illnesses. However, its predictive value for critically ill patients remains unclear. Thus, we aimed to perform a systematic review and meta-analysis to investigate the relationship between PA and survival in such a patient population.Materials and methodsWe searched for relevant studies in PubMed, Embase, and the Cochrane database up to Jan 20, 2022. Meta-analyses were performed to determine the association between the baseline PA after admission with survival. We further conducted subgroup analyses and sensitivity analyses to explore the sources of heterogeneity.ResultsWe included 20 studies with 3,770 patients. Patients with low PA were associated with a significantly higher mortality risk than those with normal PA (OR 2.45, 95% CI 1.97–3.05, P < 0.00001). Compared to survivors, non-survivors had lower PA values (MD 0.82°, 95% CI 0.66–0.98; P < 0.00001). Similar results were also found when pooling studies reported regression analyses of PA as continuous (OR = 0.64; 95% CI 0.52–0.79, P < 0.00001) or categorical variable (OR = 2.42; 95% CI 1.76–3.34; P < 0.00001). These results were further confirmed in subgroup analyses and sensitivity analyses.ConclusionOur results indicated that PA may be an important prognostic factor of survival in critically ill patients and can nicely complement the deficiencies of other severity scoring systems in the ICU setting.

Postoperative Phase Angle and Prognosis after Cardiac Surgery: A Historical Cohort Study

“…In the ICU, a consistent association of the phase angle with the outcomes, independent of the current severity scoring systems, was reported in the literature. In our opinion, this supports its use as a candidate variable 7 for future severity scoring systems. The current study suggests the relevance of an approach combining the phase angle and hemodynamic and myocardial damage parameters to predict outcomes in postoperative care after cardiac surgery.…”

Reduction of Excessive Dietary Sodium Consumption: Effectiveness of a Prevention Intervention among Health Workers in a Large Italian Hospital

“…Most changes in body composition and nutritional status in participants undergoing the nutritional intervention were too small to be detected by bioelectrical impedance [ 29 ]. To date, this method has been used mainly for evaluating the effectiveness of training programs in athletes and monitoring the nutritional status of critically ill patients [ 30 , 31 ]. Results reported in these studies suggest that bioelectrical impedance could also be helpful in dietary intervention contexts.…”

Analysis of factors influencing the increase of extracellular water ratio in tumor patients without edema signs

“…Reduced PA can be diagnosed when PA is below 5.0° in males and 4.6° in females (Girma T et al,2017). A decrease in PA indicates poor prognosis, increased complications, and shortened survival (Zheng WH et al,2023;Scicchitano P et al,2022). This study's results revealed a strong negative correlation between PA and ECW/TBW (correlation coe cient rs=-0.896, P<0.001).…”