Prognostic Role of c-Met Overexpression in High Grade Glioma: a Meta-analysis

Abstract

4Objectives: This study aims to assess the relationship between the expression of c-Met 5 and the prognosis of high grade glioma patients. 6 Method: The MET proto-oncogene encoded c-Met protein. The gene expression data 7 of 325 patients were downloaded from CGGA. The Oncomine database analysis and 8 the prognosis analysis were conducted. Besides, meta-analysis was also performed to 9 confirm the conclusion. 10 Result: Oncomine database was identified and analyzed and results showed that the 11 MET copy number was obviously higher in glioblastoma than normal tissue 12 consistently (p<0.001). The prognostic analysis of 325 high grade glioma samples 13 showed that high c-Met expression patients had poor overall survival (OS) and 14 progression free survival (PFS) than the low c-Met expression patients dramatically 15 (HR, 2.223; 95% CI: 1.662 to 2.974; P<0.0001 and HR, 2.089; 95% CI: 1.578 to 2.770; 16 P<0.0001). 6 studies involving 503 patients were included in the meta-analysis. The 17 pooled results indicated that the high expression of c-Met was not significantly 18 associated with OS (HR =1.01, 95% CI:0.93-1.09), but strongly connected with shorter 19 PFS (HR =1.92, 95% CI:1.42-2.58, p<0.01). 20 Conclusion: c-Met overexpression has correlation with poor prognosis of high grade 21 glioma patients.22