Prognostic Role of C-Reactive Protein in Breast Cancer: A Systematic Review and Meta-Analysis

Han, Yong‐Jian; Mao, Feng; Wu, Ying; Fu, Xiaonan; Zhu, Xiaoli; Zhou, Shuli; Zhang, Wei; Sun, Qiang; Zhao, Yulan

doi:10.5301/jbm.2011.8872

Cited by 93 publications

(69 citation statements)

References 31 publications

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“…CRP is increased in the circulation in response to acute inflammation, infection and tissue damage. Studies reporting a higher level of CRP in breast carcinoma cells claimed that elevated CRP levels were associated with an increased risk of breast cancer (29) or had a prognostic value in patients with breast cancer (30). By contrast, the present study indicates that the cancer state in the body increases CRP levels to fight against tumor cells.…”

Section: Discussioncontrasting

confidence: 53%

CXCL8, IL-1β and sCD200 are pro-inflammatory cytokines and their levels increase in the circulation of breast carcinoma patients

et al. 2016

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Abstract. The influence of biomarkers on carcinogenesis has been investigated extensively. Whether they promote carcinogenesis or work against cancer development remains to be elucidated. To the best of our knowledge, the novel molecule cluster of differentiation 200 (CD200) has not been studied on human breast cancer subjects. The present study aimed to evaluate interleukin-1β (IL-1β), C-X-C motif chemokine ligand 8 (CXCL8), cancer antigen 15.3 (CA 15.3) and the soluble CD200 (sCD200) levels in the serum samples of breast carcinoma patients in order to predict their role in breast carcinoma. The subjects included individuals with early and advanced stage breast cancers, as well as healthy controls. Commercially available ELISA kits were used to measure the serum concentrations of sCD200, IL-1β, CXCL8, CA 15.3, C-reactive protein (CRP) and leukocyte count. A total of 130 subjects were recruited; 50 early stage cancer, 50 advanced stage and 30 control subjects. Serum sCD200, CXCL8, IL-1β and CRP levels were significantly higher in the early as well as the advanced stage breast cancer patients compared to the control group. The level of CA 15.3 was statistically different between early and advanced stage. There were significant positive correlations between IL-1β and CXCL8, and IL-1β and serum sCD200 levels in the control group. These correlations did not persist in the early or the advanced stage cancer groups except CRP and CA 15.3, but new correlations appeared between serum sCD200 level and leukocyte count for advanced stage breast cancer group. Multivariate regression correlation analysis revealed positive correlation between IL-1β and sCD200; and IL-1β and CXCL8. In conclusion, sCD200, CXCL8, CA 15.3 and IL-1β are proinflammatory molecules and their levels are influenced in breast cancer patients.

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Section: Discussioncontrasting

confidence: 53%

CXCL8, IL-1β and sCD200 are pro-inflammatory cytokines and their levels increase in the circulation of breast carcinoma patients

et al. 2016

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“…Currently, there is a strong evidence for the elevated levels of CRP in patients with chronic infections and autoimmune diseases [7][8][9]. In addition, elevated levels of CRP had been found in patients with cancers [9][10][11][12]15]. Previous studies also showed that elevated levels of CRP were associated with decreased survival and increased risk of mortality in various cancers [16][17][18][19][20][21][22].…”

Section: Discussionmentioning

confidence: 92%

“…Currently, there is a strong evidence for important roles of CRP in the development of chronic infections and autoimmune diseases [7,8]. Previous studies suggest that patients with cancer often have increased levels of circulating CRP, and increased level of serum CRP has been proven to be an important prognostic factor in several types of cancers including colorectal cancer and breast cancer [9][10][11]. However, the prognostic significance of serum CRP level in patients with osteosarcoma was still unclear.…”

Section: Introductionmentioning

confidence: 97%

Serum C-reactive protein and overall survival of patients with osteosarcoma

Tian

Wang

et al. 2015

Tumor Biol.

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Increased level of serum C-reactive protein (CRP) has been identified as an important prognostic factor in several types of cancers. However, the prognostic significance of serum CRP levels in patients with osteosarcoma was still unclear. A retrospective cohort study of 85 patients was performed to assess the prognostic significance of serum CRP level in osteosarcoma. Both log-rank test and multivariable analysis by Cox regression model were used to assess the impact of serum CRP levels on the overall survival in patients with osteosarcoma. Among those 85 patients, 28 (32.9 %) had high serum CRP level (>1 mg/dL), while the other 57 (67.1 %) patients had normal serum CRP level (≤ 1 mg/dL). There was no obvious difference in the baseline characteristics between high CRP group and normal CRP group. Kaplan-Meier product-limit method showed that patients with high serum CRP levels had significantly poorer overall survival than those patients with normal serum CRP levels (log-rank test P = 0.0008). Multivariable analysis by Cox regression model further showed that high serum CRP level was an independent predictor of poor overall survival (hazard ratio [HR] = 2.39; 95 % confidence interval [95 % CI] 1.22-4.67, P = 0.01). Thus, serum CRP level has an important prognostic significance in patients with osteosarcoma, and high CRP level is associated with worse overall survival.

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“…Poorer prognosis in cancer patients, including those of breast cancer was also reported (1,14), but evidence on the association of CRP with breast cancer risk is inconsistent. The association may also differ by degree of body adiposity.…”

Section: Introductionmentioning

confidence: 99%

Circulating C-Reactive Protein and Breast Cancer Risk—Systematic Literature Review and Meta-analysis of Prospective Cohort Studies

Chan

Bandera

Greenwood

et al. 2015

Cancer Epidemiology, Biomarkers &Amp; Prevention

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We conducted a systematic literature review to explore the association between circulating C-reactive protein (CRP), a low-grade inflammation biomarker, and breast cancer risk. Relevant prospective studies in women were identified in PubMed and Web of Science until February 2015. Random-effects doseresponse meta-analysis was conducted, overall and in postmenopausal women. Twelve out of 15 studies identified were included in the meta-analysis on any breast cancers (3,522 cases; 69,610 women) and nine on postmenopausal breast cancer (2,516 cases; 36,847 women). For each doubling of CRP concentration, a 7% [95% confidence interval (CI), 2%-12%] and 6% (95% CI, 1%-11%) increased risk was observed (I 2 ¼ 47% and 32%; P heterogeneity ¼ 0.04 and 0.17), respectively. The association was linear over most of the range of CRP concentrations. Positive associations remained in the studies that examined the exclusion of early years of follow-up. Associations were attenuated in studies adjusted for lifestyle factors, which partly explained the significant heterogeneity between studies in the overall analysis. On average, the associations in studies adjusted or not adjusted for body mass index were similar. Low-grade inflammation may have a role in breast cancer development. Additional prospective studies are needed to better understand confounding and effect modification from lifestyle factors. Cancer Epidemiol Biomarkers Prev; 24(10);

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Prognostic Role of C-Reactive Protein in Breast Cancer: A Systematic Review and Meta-Analysis

Abstract: CRP has a critical prognostic value in patients with breast cancer as an inflammation biomarker.

Cited by 93 publications

References 31 publications

CXCL8, IL-1β and sCD200 are pro-inflammatory cytokines and their levels increase in the circulation of breast carcinoma patients

CXCL8, IL-1β and sCD200 are pro-inflammatory cytokines and their levels increase in the circulation of breast carcinoma patients

Serum C-reactive protein and overall survival of patients with osteosarcoma

Circulating C-Reactive Protein and Breast Cancer Risk—Systematic Literature Review and Meta-analysis of Prospective Cohort Studies

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