Prognostic Role of Circular RNAs Expression in Bladder Carcinoma: A Meta-Analysis

Wang, Siyuan; Fu, Shengqiang; Chen, Qiang; Liu, Yutang; Li, Zhilong; Sun, Ting

doi:10.1089/gtmb.2020.0079

Cited by 11 publications

(5 citation statements)

References 40 publications

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“…Moreover, most patients are diagnosed too late and thus have a poor prognosis. Even where surgical resection is possible, the prognosis of GBC is still unsatisfactory ( Dwivedi et al, 2015 ; Wang S. et al, 2020 ). Hence, it is urgent to discover effective early biomarkers and therapeutic targets.…”

Section: Circmto1 In Various Human Cancersmentioning

confidence: 99%

The Roles of circMTO1 in Cancer

Liu

Xiong

Wan

et al. 2021

Front. Cell Dev. Biol.

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Circular RNAs (circRNAs) are a recently discovered type of covalently-closed circular non-coding RNAs, mainly formed by non-sequential back-splicing of precursor mRNAs (pre-mRNAs). Recent studies have demonstrated that circRNAs can have either oncogenic or tumor-suppressor roles depending on the cellular context. CircRNA mitochondrial tRNA translation optimization 1 (circMTO1), a recently reported circular RNA originating from exons of MTO1 located on chromosome 6q13, was proved to be abnormally expressed in many malignant tumors, such as hepatocellular carcinoma, gastric carcinoma and colorectal cancer, resulting in tumor initiation and progression. However, there are no reviews focusing on the roles of circMTO1 in cancer. Here, we first summarize the main biological characteristics of circMTO1, and then focus on its biological functions and the possible underlying molecular mechanisms. Finally, we summarize the roles of circMTO1 in cancer and discuss future prospects in this area of research.

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Section: Circmto1 In Various Human Cancersmentioning

confidence: 99%

The Roles of circMTO1 in Cancer

Liu

Xiong

Wan

et al. 2021

Front. Cell Dev. Biol.

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“…As shown by Li et al, abnormally expressed circRNAs have demonstrated promising potential as diagnostic biomarkers in colorectal cancer and prognostic factors to determine the overall survival in these populations 27 . Furthermore, Wang et al proposed that certain circRNAs are associated with the prognosis and clinicopathological features of bladder cancer patients 28 . As discussed in this study, circMYLK regulates pivotal signaling pathways and cancer‐related cellular processes, including cell proliferation, invasion, and apoptosis through miRNA modulation.…”

Section: Discussionmentioning

confidence: 56%

“… 27 Furthermore, Wang et al proposed that certain circRNAs are associated with the prognosis and clinicopathological features of bladder cancer patients. 28 As discussed in this study, circMYLK regulates pivotal signaling pathways and cancer‐related cellular processes, including cell proliferation, invasion, and apoptosis through miRNA modulation. Moreover, circMYLK can be a valuable prognostic factor in various cancers, including HCC, renal cancer, bladder cancer, NSCLC, ovarian cancer, and colorectal cancer.…”

Section: Discussionmentioning

confidence: 85%

Circular RNA MYLK as a prognostic biomarker in patients with cancers: A systematic review and meta‐analysis

et al. 2022

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Background Circular RNA (circRNA) myosin light chain kinase (circMYLK) has recently received increasing attention in cancer biology. Several studies have suggested that circMYLK expression is linked to prognosis and clinicopathological characteristics of various malignancies. Aims This study was carried out to systematically review the impact of circMYLK on the progression of multiple cancers and assess the significance of circMYLK in the prognosis and clinicopathological features of the patients. Methods PubMed, Web of Science, and Embase were systematically searched until July 2, 2021. For qualitative synthesis, the signaling pathways of circMYLK in the progression of different cancers were summarized. Regarding the meta‐analysis, overall survival (OS) and eight clinicopathological characteristics of patients with cancers were addressed. Odds ratios (ORs) and hazard ratios (HRs) were calculated to assess the association of circMYLK with prognostic and clinicopathological features. Results Twelve studies investigating the role of circMYLK in cancer progression met the inclusion criteria. Among these, seven studies investigated the prognostic significance of circMYLK, and nine studies ascertained the clinicopathological importance of circMYLK in patients with various malignancies. CircMYLK acts as a tumor promoter circRNA, leading to migration, proliferation, invasion, and metastasis of neoplastic cells and inhibiting their apoptosis through interaction with several miRNAs and corresponding downstream signaling pathways. Overexpression of circMYLK was correlated with poor OS (HR = 1.75; 95% confidence interval [CI] 1.52–2.02) and larger tumor size (OR = 2.90; 95% CI 1.03–8.15), higher T stage (OR = 2.49; 95% CI 1.20–5.18), lymph node metastasis (OR = 2.55; 95% CI 1.41–4.62), and higher TNM stage (OR = 4.62; 95% CI 2.99–7.14). Conclusions CircMYLK is involved in the progression of numerous cancers via different signaling pathways. This circRNA can serve as a promising prognostic biomarker for several types of malignancies. Furthermore, high expression of circMYLK is associated with advanced clinicopathological characteristics in various tumors.

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“…Therefore, circ-ITCH can be used as a molecular therapeutic target and prognostic marker for human cancer. Siyuan Wang and Shengqiang Fu also confirmed that circ-ITCH is associated with better clinicopathological indicators, and circ-ITCH has potential as a biomarker ( 83 ).…”

Section: Discussionmentioning

confidence: 82%

Intelligent structure prediction and visualization analysis of non-coding RNA in osteosarcoma research

Chen,

He,

Liu

et al. 2024

Front. Oncol.

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BackgroundOsteosarcoma (OS) is the most common bone malignant tumor in children and adolescents. Recent research indicates that non-coding RNAs (ncRNAs) have been associated with OS occurrence and development, with significant progress made in this field. However, there is no intelligent structure prediction and literature visualization analysis in this research field. From the perspective of intelligent knowledge structure construction and bibliometrics, this study will comprehensively review the role of countries, institutions, journals, authors, literature citation relationships and subject keywords in the field of ncRNAs in OS. Based on this analysis, we will systematically analyze the characteristics of the knowledge structure of ncRNAs in OS disease research and identify the current research hotspots and trends.MethodsThe Web of Science Core Collection (WoSCC) database was searched for articles on ncRNAs in OS between 2001 and 2023. This bibliometric analysis was performed using VOSviewers, CiteSpace, and Pajek.ResultsThis study involved 15,631 authors from 2,631 institutions across 57 countries/regions, with a total of 3,642 papers published in 553 academic journals. China has the highest number of published papers in this research field. The main research institutions include Nanjing Medical University (n = 129, 3.54%), Shanghai Jiao Tong University (n = 128, 3.51%), Zhengzhou University (n = 110, 3.02%), and China Medical University (n = 109, 2.99%). Oncology Letters (n =139, 3.82%), European Review for Medical Pharmacological Sciences (120, 3.31%), and Molecular Medicine Reports (n = 95, 2.61%) are the most popular journals in this field, with Oncotarget being the most co-cited journal (Co-Citation = 4,268). Wei Wang, Wei Liu, and Zhenfeng Duan published the most papers, with Wang Y being the most co-cited author. “miRNA”, “lncRNA” and “circRNA” are the main focuses of ncRNAs in OS studies. Key themes include “migration and invasion”, “apoptosis and proliferation”, “prognosis”, “biomarkers” and “chemoresistance”. Since 2020, hotspots and trends in ncRNA research in OS include “tumor microenvironment”, “immune” and “exosome”.ConclusionThis study represents the first comprehensive bibliometric analysis of the knowledge structure and development of ncRNAs in OS. These findings highlight current research hotspots and frontier directions, offering valuable insights for future studies on the role of ncRNAs in OS

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Prognostic Role of Circular RNAs Expression in Bladder Carcinoma: A Meta-Analysis

Cited by 11 publications

References 40 publications

The Roles of circMTO1 in Cancer

The Roles of circMTO1 in Cancer

Circular RNA MYLK as a prognostic biomarker in patients with cancers: A systematic review and meta‐analysis

Intelligent structure prediction and visualization analysis of non-coding RNA in osteosarcoma research

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