Prognostic role of controlling nutritional status score in hematological malignancies

Zhang, Yijing; Chen, Qiuni; Lu, Chuanyang; Yu, Liang

doi:10.1080/16078454.2022.2078040

Cited by 15 publications

(5 citation statements)

References 56 publications

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“…Whereas, the correlation between dyslipidemia and lymphoma or multiple myeloma has not been reported. More recently, studies aimed at lipids in DLBCL patients appeared to indicate prognosis [29][30][31].…”

Section: Discussionmentioning

confidence: 99%

Dyslipidemia in diffuse large B cell lymphoma based on the genetic subtypes: a single-center study of 259 Chinese patients

Shen

Shi

et al. 2023

Preprint

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Background: Diffuse large B-cell lymphoma (DLBCL) is a kind of highly heterogeneous non-Hodgkin lymphoma both in clinical and genetic terms. DLBCL is admittedly categorized into 6 subtypes by genetics, which contains MCD, BN2, EZB, N1, ST2 and A53. Dyslipidemia is relevant to a multitude of solid tumors and has recently been reported associated with hematologic malignancy. We aim to present a retrospective study investigating dyslipidemia in DLBCL based on the molecular subtypes. Results: This study concluded 259 patients with newly diagnosed DLBCL and their biopsy specimens were available for molecular typing. Results show that the incidence of dyslipidemia (87.0%, p<0.001) is higher in the EZB subtype than in others, especially the hypertriglyceridemia (78.3%, p=0.001) in the EZB subtype. Based on the pathological gene-sequencing, patients with BCL2 gene fusion mutation are significantly correlative with hyperlipidemia (76.5%, p=0.006) and hypertriglyceridemia (88.2%, p=0.002). Nevertheless, the occurrence of dyslipidemia has no remarkable influence on prognosis. Conclusion: In summary, dyslipidemia connects with the genetic heterogeneity in DLBCL while without significant influence on survival.

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Section: Discussionmentioning

confidence: 99%

Dyslipidemia in diffuse large B cell lymphoma based on the genetic subtypes: a single-center study of 259 Chinese patients

Shen

Shi

et al. 2023

Preprint

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show abstract

Section: Discussionmentioning

confidence: 99%

Dyslipidemia in diffuse large B-cell lymphoma based on the genetic subtypes: a single-center study of 259 Chinese patients

Xie

Shen

et al. 2023

Front. Oncol.

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BackgroundDiffuse large B-cell lymphoma (DLBCL) is a kind of highly heterogeneous non-Hodgkin lymphoma, both in clinical and genetic terms. DLBCL is admittedly categorized into six subtypes by genetics, which contain MCD, BN2, EZB, N1, ST2, and A53. Dyslipidemia is relevant to a multitude of solid tumors and has recently been reported to be associated with hematologic malignancies. We aim to present a retrospective study investigating dyslipidemia in DLBCL based on the molecular subtypes.ResultsThis study concluded that 259 patients with newly diagnosed DLBCL and their biopsy specimens were available for molecular typing. Results show that the incidence of dyslipidemia (87.0%, p <0.001) is higher in the EZB subtype than in others, especially hypertriglyceridemia (78.3%, p = 0.001) in the EZB subtype. Based on the pathological gene-sequencing, patients with BCL2 gene fusion mutation are significantly correlative with hyperlipidemia (76.5%, p = 0.006) and hypertriglyceridemia (88.2%, p = 0.002). Nevertheless, the occurrence of dyslipidemia has no remarkable influence on prognosis.ConclusionIn summary, dyslipidemia correlates with genetic heterogeneity in DLBCL without having a significant influence on survival. This research first connects lipids and genetic subtypes in DLBCL.

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“…The possible mechanisms for Alb reduction could be (16)(17)(18), ( 1) increased catabolism of Alb, (2) loss of Alb due to changes in vascular permeability from the rapid increase of excessive inflammatory factors in the peripheral blood of patients as a result of local inflammatory cascade after the development of lymphoma. TC, which is an important component of the cell membrane, is associated with the proliferation, migration, and immune response of malignant tumor cells and can promote the recognition of tumor cells by immune cells by enhancing the antigen presentation function of monocytes (19)(20)(21). As a member of the inflammatory cell family, LYM is involved in altering the tumor microenvironment.…”

Section: Discussionmentioning

confidence: 99%

Prognostic value of nutritional status in patients with human immunodeficiency virus infection-related lymphoma

Liu

Hu²,

Lv³

et al. 2022

Front. Nutr.

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ObjectiveTo investigate the predictive value of nutritional status on the prognosis of patients with human immunodeficiency virus (HIV) infection-related lymphoma.Materials and methodsA total of 149 patients with HIV infection-related lymphoma who were admitted to our hospital from August 2012 to May 2022 were selected as research subjects. Based on the patient prognosis, they were divided into a poor prognosis group (n = 30) and a good prognosis group (n = 119). General data from patients in both groups were collected, and the nutritional status of the patients was evaluated using the Controlling Nutritional Status (CONUT) score. Factors affecting the prognosis of HIV infection-related lymphoma were analyzed using univariate and multivariate analyses, and a prediction model was developed based on the analyzed factors. The receiver operating characteristic (ROC) curve was used to analyze the prediction model of the CONUT score alone and included the CONUT score in the prognosis of patients with HIV infection-related lymphoma. The predictive value of the data was assessed, and a survival curve was drawn to compare the survival of patients with different nutritional statuses.ResultsThere were significant differences in age, B symptoms, treatment conditions, International Prognostic Index (IPI), pathological stage, Eastern Collaborative Tumor Group physical status score (ECOG PS), CD4+ cell count, β2 microglobulin, and lactate dehydrogenase (LDH) between the poor prognosis group and the good prognosis group (p < 0.05). The CONUT score of the poor prognosis group was higher than that of the good prognosis group, and the difference was statistically significant (p < 0.05). A univariate analysis demonstrated that the age, B symptoms, treatment status, IPI, pathological stage, ECOG PS, CD4+ cell count, β2 microglobulin, LDH, and CONUT score were prognostic factors for patients with HIV infection-related lymphoma (p < 0.05). The results of a multivariate regression analysis demonstrated that the age, B symptoms, treatment status, IPI, pathological stage, ECOG PS, and CONUT score were independent risk factors for the prognosis of patients with HIV infection-related lymphoma (p < 0.05). The prediction model was constructed according to the multivariate Cox regression analysis results. The model formula was as follows: Logit(p) = −10.687 + 1.728 × age + 1.713 × B symptoms + 1.682 × treatment status + 1.810 × IPI + 1.643 × pathological stage + 1.584 × ECOG PS + 1.779 × CONUT score. The ROC curve was used to analyze the predictive value of the CONUT score alone and the predictive model including the CONUT score on the prognosis of patients with HIV infection-related lymphoma. The predictive value of the prognosis of patients with tumors was higher (p < 0.05). According to the results of the ROC curve analysis, the patients were divided into a high CONUT group (CONUT > 6.00 points, n = 31) and a low CONUT group (CONUT ≤ 6.00 points, n = 118) based on the Optimum threshold of the CONUT score. The survival curve showed that the survival rate of the high CONUT group was lower than that of the low CONUT group (p < 0.05).ConclusionThe poor prognosis of HIV infection-related lymphoma is related to nutritional status, which is an independent risk factor affecting the prognosis of patients and can be used as a practical indicator to predict the prognosis of patients.

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Prognostic role of controlling nutritional status score in hematological malignancies

Cited by 15 publications

References 56 publications

Dyslipidemia in diffuse large B cell lymphoma based on the genetic subtypes: a single-center study of 259 Chinese patients

Dyslipidemia in diffuse large B cell lymphoma based on the genetic subtypes: a single-center study of 259 Chinese patients

Dyslipidemia in diffuse large B-cell lymphoma based on the genetic subtypes: a single-center study of 259 Chinese patients

Prognostic value of nutritional status in patients with human immunodeficiency virus infection-related lymphoma

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