Prognostic Role of microRNA-155 in Various Carcinomas: Results from a Meta-Analysis

Abstract

Abstract. BACKGROUND:Recent studies have shown that microRNAs (miRNA) have prognostic values in cancers. This meta-analysis seeks to summarize the global predicting role of miR-155 for survival in patients with a variety of carcinomas. METHODS: Eligible studies were identified through multiple search strategies. Data were extracted from studies investigating the relationship between miR-155 expression and survival in cancer patients. Combined hazard ratios (HRs) of miR-155 for outcome were analyzed. RESULTS: A total of 16 studies dealing with various carcinomas were included for this meta-analysis. For overall survival, higher miR-155 expression could significantly predict worse outcome with the pooled HR of 2.057 (95% CI: 1.392-3.039). For relapse or progress-free survival, elevated miR-155 was also a significant predictor, with a combined HR of 1.918 (95% CI: 1.311-2.806,). In addition, subgroup analysis showed that higher expression of miR-155 had the trends to predict worse outcome in lung cancer. However, the HRs did not reach the statistical significance. CONCLUSION: Our findings suggest that miR-155 detection has a prognostic value in cancer patients. Regularly measuring miR-155 expression may be useful in clinical practice.

Combining Anti-Mir-155 with Chemotherapy for the Treatment of Lung Cancers

“…In contrast with some of the literature (17, 18, 33-37), we found that in most of the analyzed cancer datasets, miR-155 expression and TP53 mRNA expression by itself were not sufficient to be associated with OS ( Table 1 ). In fact, significant correlations between miR-155 and survival could only be found in the leukemia cohorts.…”

“…In the 17p deletion group, miR-155 was the most upregulated miRNA (14). Moreover, we and others have demonstrated that miR-155 has prognostic significance in multiple types of tumors, including leukemia (15, 16) and lung cancer (17, 18). …”

“…MiR-155 was found to have prognostic impact in patients with various types of cancer (17) including lung cancer (18), leukemia (15, 16), breast cancer (33), renal cell carcinoma (34), glioma (35), colorectal cancer (36) and gallbladder carcinoma (37). We additionally assessed the correlation of miR-155 with survival in two independent and already published CLL cohorts (CLL-NEJM (21) and CLL-Clin Cancer Res (22)), in a new ALL cohort (ALL-MDACC), and in four lung cancer datasets (2 new cohorts, NSCLC-Italy and lung adenocarcinoma-MDACC, and the TCGA cohorts for lung adenocarcinoma and squamous cell carcinoma).…”

miR-155 as a diagnostic and prognostic marker in hematological and solid malignancies

“…Relevant works are listed in Tab. 1, including selected adopted information from meta-analysis of He and coworkers [96]. These authors summarize eligible studies and show that higher expression of miR-155 is associated with poor survival in patients with diverse types of cancer.…”

Hypertrophy of Ligamentum Flavum in Lumbar Spine Stenosis Is Associated with Increased miR-155 Level

“…Notably, a significant increase in the expression of miR-155 was observed in fibroblast cells and tissues from rheumatoid arthritis patients [24]. MiR-155 is a typical multifunctional miRNA that plays crucial role in various physiological and pathological processes, such as hematopoietic lineage differentiation, immunity, cancer, cardiovascular disease, and inflammatory response [25, 26]. …”