Prognostic Role of MRI Enhancement Features in Patients With Breast Cancer: Value of Adjacent Vessel Sign and Increased Ipsilateral Whole-Breast Vascularity

Abstract

In conjunction with the standard BI-RADS MRI lexicon, the adjacent vessel sign and increased ipsilateral whole-breast vascularity may serve as additional predictors of a poor prognosis.

Host genetic modifiers of nonproductive angiogenesis inhibit breast cancer

“…Additionally, species-specific RNAseq (SSRS) and quantitative immunofluorescent imaging were used to identify the potential TME modifier(s) that might alter tumor growth and vascular function. We found that SS.BN3 IL2Rγ tumors form a more tortuous and denser vascular network and have altered vascular function, which was similar to qualitative perfusion imaging in patients that had lower grade breast cancers [6] and improved five year overall survival [11]. The changes in the SS.BN3 IL2Rγ tumors also coincided with altered expression of DLL4, which was previously linked with nonproductive angiogenesis [12].…”

“…Tumor growth requires vascular supply [23] and changes in vascular function are correlated with breast tumor grade [6] and overall survival [11], leading us to examine whether the TME-specific modifier(s) on RNO3 altered the tumor vasculature. Compared with SS IL2Rγ tumors, the blood vasculature of TNBC tumors implanted in the SS.BN3 IL2Rγ genetic background was denser and more tortuous (Figure 2A-E).…”

Magnetic Resonance Imaging Enhancement Features Before and After Neoadjuvant Chemotherapy in Patients With Breast Cancer

“…We also evaluated the usefulness of IIWBV for an early prediction of the response, because our previous study identified IIWBV as predicting poor prognostic indicators (tumor size, lymph node status, and nuclear and histological grade). 26,38 In this study, however, there was no significant difference (P = 0.068) in the degree of IIWBV on baseline or follow-up MRI between responders and nonresponders. Furthermore, the change in IIWBV after NAC was not correlated with the response (P = 0.081).…”

A Rim-Enhanced Mass with Central Cystic Changes on MR Imaging: How to Distinguish Breast Cancer from Inflammatory Breast Diseases?

“…In contrast, the wall of abscesses had more new vessels and a higher permeability, and therefore this type of lesion could have a washout pattern. Because of angiogenesis, the AVS has been considered as an indicator of malignancy [18], [22]. Inflammatory breast diseases have been reported as the most common benign disease with positive AVS [18].…”