Prognostic role of preoperative serum total cholesterol and high-density lipoprotein in lung adenocarcinoma

Abstract

Objective: To evaluate the clinical significance of the preoperative plasma lipid profile, including triglycerides (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C), in patients with lung adenocarcinoma (LUAD) status post complete resection. Methods: Clinical data, including preoperative plasma profile levels, were retrospectively collected and reviewed in 304 patients with LUAD who underwent radical lung resection between 2016–2017. The overall survival (OS) and disease-free survival (DFS) were assessed by the Kaplan–Meier method and the Cox proportional hazards regression model. Results: TC ≤ 3.58 and HDL-C ≤ 1.01 were deemed as independent preoperative risk factors for OS, and HDL-C ≤ 1.01 was an independent preoperative risk factor for DFS. In the multivariate analyses involving OS and DFS, an increased TC level (HR, 0.504; 95% CI, 0.324–0.782, P = 0.002) was significantly associated with better OS. Additionally, a decreased HDL-C level was significantly associated with worse OS (HR, 0.665; 95% CI, 0.443–0.999, P = 0.049) and DFS (HR, 0.619; 95% CI, 0.420–0.912, P = 0.015). Conclusions: In patients with LUAD, increased TC levels may predict better OS, while decreased levels of HDL-C may predict worse outcomes for both DFS and OS.