Prognostic role of the ABO blood types in Chinese patients with curatively resected non-small cell lung cancer: a retrospective analysis of 1601 cases at a single cancer center

Abstract

BackgroundA positive association between the ABO blood types and survival has been suggested in several malignancies. The aim of this study was to assess the role of the ABO blood types in predicting the prognosis of Chinese patients with curatively resected non-small cell lung cancer (NSCLC).MethodsWe retrospectively analyzed 1601 consecutive Chinese patients who underwent curative surgery for NSCLC between January 1, 2005 and December 31, 2009. The relationship between the ABO blood types and survival was investigated. In addition, univariate and multivariate analyses were performed.ResultsGroup 1 (patients with the blood type O or B) had significantly prolonged overall survival (OS) compared with group 2 (patients with the blood type A or AB), with a median OS of 74.9 months versus 61.5 months [hazard ratio (HR) 0.83; 95% confidence interval (CI) 0.72–0.96; P = 0.015]. Additionally, group 1 had significantly longer disease-free survival (DFS; HR 0.86; 95% CI 0.76–0.98; P = 0.022) and locoregional relapse-free survival (LRFS; HR 0.79; 95% CI 0.64–0.98; P = 0.024) than group 2. The association was not significantly modified by other risk factors for NSCLC, including smoking status, pathologic tumor-node-metastasis stage, pT category, pN category, and chemotherapy.ConclusionsThere is an association between the ABO blood types and the survival of Chinese patients with resected NSCLC. Patients with the blood type O or B had significantly prolonged OS, DFS, and LRFS compared with those with the blood type A or AB.

Prognostic role of ABO blood type in patients with extranodal natural killer/T cell lymphoma, nasal type: a triple-center study

“…In the present triple-center study, we found that ABO blood type (O vs. non-O) is an independent prognostic factor of PFS and OS and a useful predictor of treatment response in patients with ENKTL. Moreover, the proportions of blood types O, A, B, and AB were similar to those reported previously for Chinese patients with solid tumors [ 23 , 24 ]. However, because no studies published in English to date have investigated the prognostic role of ABO blood type on the outcome of lymphoma, we could not compare our results with published information.…”

“…Rahbari et al [ 29 ] investigated the influence of ABO blood type on 627 patients with pancreatic cancer and found blood type O as a favorable prognostic factor (hazard ratio [HR] = 0.78, P = 0.037). Similarly, Li et al [ 24 ] evaluated the prognostic role of ABO blood type in 1601 patients with curatively resected non-small cell lung cancer (NSCLC), and they found that patients with blood type O or B had significantly prolonged OS and disease-free survival (DFS) compared with those with blood type A or AB. Moreover, in the study of Gershman et al [ 28 ] of a large cohort of 2086 patients with bladder cancer, the results indicated that blood type non-O was associated with significantly shorter recurrence-free survival (RFS, P = 0.04) and cancer-specific survival (CSS, P = 0.02).…”

“…Our results are consistent with a previous study in which blood type AB was reported as a favorable prognostic factor for colon cancer [ 23 ]. In contrast, some studies found that blood type AB was an unfavorable prognostic factor for several other types of cancer [ 24 , 25 ]. Because the number of patients with blood type AB is the lowest among all blood types, the influence of blood type AB on the prognostic value of ABO blood type in ENKTL may be rather small.…”

“…Several studies have found that certain ABO blood types are associated with a high risk of certain cancers [ 20 , 21 ]. Recently, the association between ABO blood type and the survival outcome of cancer patients has also drawn much attention, which has been demonstrated in various solid tumors, including pancreatic cancer [ 22 ], colon cancer [ 23 ], lung cancer [ 24 ], and esophageal cancer [ 25 ]. However, to the best of our knowledge, the prognostic value of ABO blood type in lymphoma has never been investigated.…”

ABO Blood Type Has No Impact on Survival in Patients with Endometrial Carcinoma – A cohort study of 1074 patients

“…And the overall survival, patients-free survival and locoregional relapse-free survival were signi cantly prolonged in patients with a blood group of O or B compared with patients with blood group A or AB. [19] There are currently few studies on ABO blood type and EC. A retrospective cohort study of 203 patients with type I EC found that patients with type A blood had a lower risk of developing G3 tumors than patients with non-type A blood.…”