2017
DOI: 10.1155/2017/1928021
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Prognostic Role of the MicroRNA-200 Family in Various Carcinomas: A Systematic Review and Meta-Analysis

Abstract: Background/Aims. The miRNA-200 (miR-200) family may act as key inhibitors of epithelial-to-mesenchymal transition. However, the potential prognostic value of miR-200s in various human malignancies remains controversial. This meta-analysis analyzed the associations between miR-200 levels and survival outcomes in a variety of tumors. Methods. Eligible published studies were identified by searching the Embase, PubMed, CINAHL, and Google scholar databases. Patient clinical data were pooled, and pooled hazard ratio… Show more

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Cited by 17 publications
(20 citation statements)
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“…However, there is a discrepancy of microRNA expression in PDAC tissue and corresponding preoperative blood serum samples. Our inverse and apparently contradicting expression data of EMT-related microRNAs, particularly the microRNA-200 family, are in accordance with results of previous tumor marker studies [ 12 , 40 , 41 , 42 ]. It is supposed that the increase of circulating microRNA-200 is the result of more circulating tumor cells (CTC) with predicted worse survival in various cancers [ 43 , 44 , 45 ].…”
Section: Discussionsupporting
confidence: 90%
“…However, there is a discrepancy of microRNA expression in PDAC tissue and corresponding preoperative blood serum samples. Our inverse and apparently contradicting expression data of EMT-related microRNAs, particularly the microRNA-200 family, are in accordance with results of previous tumor marker studies [ 12 , 40 , 41 , 42 ]. It is supposed that the increase of circulating microRNA-200 is the result of more circulating tumor cells (CTC) with predicted worse survival in various cancers [ 43 , 44 , 45 ].…”
Section: Discussionsupporting
confidence: 90%
“…Either way, our results are supported by Lee et al and their meta-analysis on the prognostic value of miR-200 in cancer. It revealed that low expression of miR-200 in cancer tissue correlates with prolonged OS, whereas high expression of circulating miR-200 correlates with shorter OS of patients, a clinical observation that remains to be untangled at the molecular level [54].…”
Section: Discussionmentioning
confidence: 99%
“…MicroRNAs (miRNAs) are a class of small (19–22 nucleotides), endogenous and noncoding RNAs that suppress gene expression by forming base pairs with target mRNAs and thereby regulate various pathophysiological processes implicated in cancer development and progression . Among miRNAs, miR‐200 family members (miR‐200a, miR‐200b, miR‐200c, miR‐141 and miR‐429) act as key inhibitors of EMT by directly targeting transcriptional repressors of E‐cadherin, ZEB1 and ZEB2 . Interestingly, ZEB1 binds to the promoter regions of both miR‐200 genomic clusters (miR‐200b/200a/429 and miR‐200c/141) and suppresses their transcription, suggesting that miR‐200 and ZEB1 form a double‐negative feedback loop to control cell migration, invasion and EMT .…”
Section: Introductionmentioning
confidence: 99%