Prognostic role of the recepteur d'origine nantais (RON) expression in primary high-grade osteosarcoma

Tyrosine kinase inhibitors in osteosarcoma: Adapting treatment strategiesa

“…Conflicting reports emerged regarding the status of HGFR as a prognostic factor. While one study showed that HGFR did not reach significance as an indicator of overall survival and event-free survival, another established that the recepteur d'Origine Nantais (RON), a transmembrane protein from the HGFR family, has a strong correlation with poor chemotherapy response and reduced survival times, making it a useful prognostic marker [57] . Furthermore, HGFR was found to be an important factor in the aggressive behavior of OS, as it showed greater staining with the MIB-1 cell proliferation marker (27.65 in HGFR-positive OS; 20.99 in HGFR-negative OS) and a non-significant trend toward expression at the site of metastasis (HGFR was in 50 % of metastatic lesions and 20 % of primary lesions) [50] .…”