Prognostic Role of Twist, Slug, and Foxc2 Expression in Stage I Non–Small-Cell Lung Cancer After Curative Resection

FOXC2 Expression is Associated with Tumor Proliferation and Invasion Potential in Oral Tongue Squamous Cell Carcinoma

“…This result is consistent with previous findings in which FOXC2 expression was correlated with a poor prognosis in various cancers, including esophageal, gastric, and non-small cell lung cancer as well as extrahepatic cholangiocarcinoma [21,[26][27][28]. In the present study, multivariate analysis with Cox proportion hazard model revealed that FOXC2 expression may be a significant independent prognostic factor similar to N classification, stage classification, pattern of invasion, local recurrence, and expression of VEGF-A.…”

“…FOXC2 was previously associated with EMT [19][20][21][22][23] and tumor angiogenesis [24,25] in various cancers. Although a relationship has already been reported between the expression of FOXC2 and poor prognosis in various cancers [21,[26][27][28][29], those between the expression of FOXC2 and clinicopathological features in OSCC have not yet been investigated.…”

High Expression of Forkhead Box Protein C2 is Related to Poor Prognosis in Human Gliomas

“…Zhu et al (2013) found high FAT10 expression was related to poor prognosis in patients with gastric carcinoma. Jiang et al revealed that overexpression of Foxc2 in stage I NSCLC was associated with a worse overall survival and was an independent predictor of recurrence-free and overall survival (Jiang et al, 2012). Consistent with these previous studies, our data also found the upregulation of FOXC2 in glioma tissues compared with paired adjacent nonneoplastic brain tissues.…”

“…FOXC2 is an important regulator of epithelial to mesenchymal transition (EMT) in cancer cells. Expression of FOXC2 protein was detected in a variety of cancers, including breast adenocarcinomas (Mani et al, 2007), ovarian cancer (Liu et al, 2014), colorectal cancer (Watanabe et al, 2011), cervical cancer (Zheng et al, 2014), gastric cancer (Zhu et al, 2013) and non-small-cell lung cancer (Jiang et al, 2012). Overexpression of FOXC2 has been reported in subtypes of breast cancer which are highly metastatic, suppression of FOXC2 expression using shRNA in a highly metastatic breast cancer model blocks their metastatic ability (Hollier et al, 2013).…”

Forkhead Box Protein C2 (FOXC2) Promotes the Resistance of Human Ovarian Cancer Cells to Cisplatin In Vitro and In Vivo

“…Also, haplodeficiency of FOXC2 could lead to impaired formation of tumor blood vessels as well as reduced tumor growth, suggesting that FOXC2 is critical for tumor development and angiogenesis. Meanwhile, high expression of FOXC2 is reported to be an independent prognostic factor in glioma, esophageal cancer, gastric cancer and non-small cell lung cancer [10][11][12][13]. Recently, overexpressed FOXC2 is found to enhance the epithelial-to-mesenchymal transition and invasion of ovarian cancer cells [14].…”