Prognostic Signature and Therapeutic Value Based on Membrane Lipid Biosynthesis-Related Genes in Breast Cancer

Abstract

There is a need to improve diagnostic and therapeutic approaches to enhance the prognosis of breast cancer, the most common malignancy worldwide. Membrane lipid biosynthesis is a hot biological pathway in current cancer research. It is unclear whether membrane lipid biosynthesis is involved in the prognosis of BRCA. With LASSO regression, a 14-gene prediction model was constructed using data from the TCGA-BRCA cohort. The prediction model includes GPAA1, PIGF, ST3GAL1, ST6GALNAC4, PLPP2, ELOVL1, HACD1, SGPP1, PRKD2, VAPB, CERS2, SGMS2, ALDH3B2, and HACD3. BRCA patients from the TCGA-BRCA cohort were divided into two risk subgroups based on the model. Kaplan–Meier survival curves showed that patients with lower risk scores had significantly improved overall survival ( P = 2.49 e − 09 ). In addition, risk score, age, stage, and TNM classification were used to predict mortality in BRCA patients. In addition, the 14 genes in the risk model were analyzed for gene variation, methylation level, drug sensitivity, and immune cell infiltration, and the miRNA-mRNA network was constructed. Afterward, the THPA website then analyzed the protein expression of 14 of these risk model genes in normal and pathological BRCA tissues. In conclusion, the membrane lipid biosynthesis-related risk model and nomogram can be used to predict BRCA clinical prognosis.

Multi‐omics analysis of alcohol effects on the liver in young and aged mice

“…Changes in St6galnac4 expression are associated with various gynaecological tumours, like ovarian and breast cancer, and are considered prognostic markers for treatment outcomes. Ovarian cancer concurrent with a high degree of St6galnac4 expression has been cited as associated with unfavourable outcome 34 . Our data show an elevation of St6galnac4 in young and aged animals, which may reveal a positive correlation between heavy drinking and the development of hormone‐dependent cancers.…”

“…Ovarian cancer concurrent with a high degree of St6gal-nac4 expression has been cited as associated with unfavourable outcome. 34 Our data show an elevation of St6galnac4 in young and aged animals, which may reveal a positive correlation between heavy drinking and the development of hormone-dependent cancers. Alcohol intoxication has previously been shown to affect the endocrine system.…”

PLPP2 as a metabolic and immune marker for predicting survival and enhancing response to anti-PD1 therapy in pancreatic cancer

“…PLPPs are widely expressed in human tissues and play a role in cell signal transduction, and their upregulation has been observed in various cancers, including pancreatic adenocarcinoma, gliomas, and lung adenocarcinoma [33]. PLPP2, speci cally, plays a crucial role in breast cancer development and occurrence [34]. Our analysis revealed that PLPP2 participates in tumor cell metabolic processes and affects the immune status of the TME.…”

Taxifolin Inhibits Breast Cancer Growth by Facilitating CD8+ T Cell Infiltration and Inducing a Novel Set of Genes including Potential Tumor Suppressor Genes in 1q21.3

“…In the latter group, KRT16 [ 60 ], SERPINB3 [ 61 ], and ATP6V1C2 [ 67 ] exhibited activities favoring BC, while FA2H [ 58 ] and HRNR [ 64 ] possessed tumor-suppressive activities toward BC ( Table 1 ). ALDH3B2 [ 56 ], RDH16 [ 57 ], CD209 [ 62 ], and PSAPL1 [ 68 ] were component genes in multigene biomarkers of BC ( Table 1 ). KRT10 [ 59 ] and CYP2F1 [ 63 ] were expressed in BC, while mutations in KPRP [ 65 ] and FLG2 [ 66 ] were detected in BC.…”