Prognostic significance for colorectal carcinoid tumors based on the 8th edition TNM staging system

Gong, Piqing; Chen, Chunhua; Wang, Zhan; Zhang, Xukun; Hu, Wenxin; Hu, Zhiqian; Li, Xinxing

doi:10.1002/cam4.3431

Cited by 10 publications

(14 citation statements)

References 28 publications

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“…Standard surgery was performed based on the principles of total mesorectal excision for middle and lower rectal tumors. The TNM staging system defined by the Union for International Cancer Control (UICC), American Joint Committee on Cancer, and Union Internationale Contre Le Cancer workgroups was used for staging [6].…”

Section: Methodsmentioning

confidence: 99%

Investigation of the effect of perineural invasion on survival rates in rectal tumors.

2023

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Purpose: Colorectal cancers compose the third most common cancer group leading to death, with increasing rates in developed countries after lung and breast cancers. Rectal cancers make up about 30% of all colorectal cancers. Although many factors affecting recurrence and survival in rectal cancer have been identified, the stage of the tumor is the most important prognostic factor. However, many additional parameters that can be associated with survival and affect the adjuvant treatment plan have been identified besides the stage. Perineural invasion (PNI) is one of the parameters that can be associated with survival and affect the adjuvant treatment plan in colorectal cancers. The aim of this study is to investigate the effects of various histopathological prognostic factors, including PNI, on disease-free survival, overall survival, and recurrence rates in patients with rectal cancer who underwent surgery. Materials and methods: The clinical records of patients diagnosed with rectal cancer and operated on at the Department of General Surgery, Faculty of Medicine, Pamukkale University between 2008-2014 were reviewed. To investigate the factors affecting disease-free survival, recurrence rates, and overall survival, the presence of PNI, serum CEA levels, cTNM stage, pT stage, pN stage, number of metastatic LNs, tumor budding status, histopathological grades, lymphocyte infiltration, and presence of desmoplasia were evaluated in patients. Results: A total of 124 patients were included in the study. 42 patients (33.9%) had PNI while 82 patients (66.1%) did not have PNI. Of the 45 patients with recurrence, 26 had PNI while 19 did not have PNI. Of the 79 patients without recurrence, 16 had PNI while 63 did not have PNI. Similarly, PNI was seen more frequently in deaths related to the disease. The 3-year average survival of patients with and without PNI was 55% and 89%, respectively (p

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Section: Methodsmentioning

confidence: 99%

Investigation of the effect of perineural invasion on survival rates in rectal tumors.

2023

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“…The optimal grouping cut-off values of continuous features were measured by X-tile software to evaluate the true effect of clinical features on survival outcomes in CRC patients. The 8th edition of American Joint Committee on Cancer’s TNM staging system 11 was applied for CRC staging.…”

Section: Methodsmentioning

confidence: 99%

Predictive Nomogram for the Prediction of Early Recurrence of Colorectal Cancer

Tang¹,

Chen²,

Tian³

et al. 2021

IJGM

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Aim The prognosis of colorectal cancer (CRC) individuals after curative resection is not satisfactory due to the early recurrence. We sought to identify the affecting features of early recurrence in CRC patients. Methods A total of 3500 CRC patients underwent curative resection were retrospectively incorporated into our study. Among them, 246 patients exhibited tumor recurrence: 121 had early recurrence (≤1 year after operation) and 125 had late recurrence (>1 year after operation). A total of 246 CRC patients with recurrence were randomly assigned into the training group (N=177) or validation group (N=69) based on the ratio of 7:3. LASSO COX regression and support vector machine (SVM) were utilized to screen for the significant clinical indexes associated with the presence of early recurrence. Recurrent nomogram was created based on the above informative parameters to predict the probability of early recurrence. Results Proportion of advanced TNM stage, platelet count, systemic immune-inflammation index (SII), mean corpuscular hemoglobin concentration (MCHC), CA-199, CA-125, lactate dehydrogenase, total bile acid (TBA), urea nitrogen were significantly higher in early recurrence group compared with that in late recurrence group. Results from LASSO COX regression and support vector machine (SVM) revealed that TNM stage, CA-199, CA125, SII and TBA were strong predictors for the presence of early recurrence among postoperative CRC patients in the training group. The recurrent nomogram based on the five predictors exhibited good predictive performance as calculated by C-index (0.846, 95% CI 0.789–0.902 in the training group and 0.799, 95% CI 0.697–0.902 in the validation group) for the prediction of early recurrence. Moreover, the recurrent nomogram exhibited not only encouraging calibration ability, but also great clinical utility both in the training group and validation group. Conclusion TNM stage, CA-199, CA125, SII and TBA were closely correlated with the presence of early recurrence of CRC patients. The recurrent nomogram held well predictive ability for the identification of CRC patients with early recurrence.

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“…Obstruction is not frequent. Survival for rectal well-differentiated neuroendocrine tumors encompasses 85% at five years while it is about 60% for colon well-differentiated NETs [ 40 ]. In fact, the large part of colorectal NETs has a benign behaviour.…”

Section: Rare Tumors Of Colon and Rectummentioning

confidence: 99%

Clinical and Molecular Characteristics of Rare Malignant Tumors of Colon and Rectum

Ottaiano

Santorsola

Perri

et al. 2022

Biology

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The most frequent form of colorectal cancer is represented by adenocarcinoma being about 98% of tumor histological types. However, other rare histotypes can be found in colon and rectum (adenosquamous, goblet cell adenocarcinoma, lymphoma, medullary carcinoma, melanoma, mesenchymal, neuroendocrine, plasmacytoma, signet ring, squamous tumors). Altogether, these forms account for less than 2% of colorectal tumors. There are no specific diagnostic or therapeutic recommended approaches and most of the information available from literature derives from small and retrospective clinical series. In the present study, we provide a paramount and updated view on clinical and biologic characteristics of rare colorectal tumors.

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Prognostic significance for colorectal carcinoid tumors based on the 8th edition TNM staging system

Cited by 10 publications

References 28 publications

Investigation of the effect of perineural invasion on survival rates in rectal tumors.

Investigation of the effect of perineural invasion on survival rates in rectal tumors.

Predictive Nomogram for the Prediction of Early Recurrence of Colorectal Cancer

Clinical and Molecular Characteristics of Rare Malignant Tumors of Colon and Rectum

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