Prognostic Significance of Accessory Cells and Lymphocytes in Nasopharyngeal Carcinoma

Thymostimulin enhancement of T‐cell infiltration into head and neck squamous cell carcinoma

“…Regarding this function it seems of no surprise that a correlation between numbers of tumor-infiltrating DCs cells and T-cells has been described in the past. 25 In our study an enhancement of T-cell infiltration into the tumor after TP1 treatment was not accompanied by a denser DC infiltration. We did, however, establish a positive correlation between Tcell tumor infiltration and the capability of blood DCs to form cellular clusters with T-cells, thereby suggesting that not only numerical infiltration of DCs, as found in earlier studies, but also the functional status of the cells is of importance in cellmediated tumor-related immunologic events.…”

The Role of Immune Cells in the Tumor Microenvironment

“…DC infiltrations into tumors have been correlated to significantly prolonged patient survival and reduced incidence of recurrent or metastatic disease in patients with bladder, lung, laryngeal, oral, gastric and nasopharyngeal carcinomas (Reichert et at., 2001;Tsujitani et ai., 1987;Lespagnard et ai., 1999;Furukawa et at., 1985;Goldman et at., 1998;Giannini et at., 1991). In contrast, patients with lesions reported to be scarcely infiltrated with DC had a relatively poor prognosis (Tsujitani et at., 1990).…”

Bone Marrow‐Derived Dendritic Cells Serve as Potent Adjuvants for Peptide‐Based Antitumor Vaccines

“…These studies have resuscitated the interest to quantify the number of DCs found within tumors. A number of early studies [26‐28] reported a decreased number of DCs infiltrating tumors when compared to normal tissues. This fact has been reported for lung cancer [26], laryngeal carcinoma [27] and nasopharyngeal carcinoma [28].…”

“…A number of early studies [26‐28] reported a decreased number of DCs infiltrating tumors when compared to normal tissues. This fact has been reported for lung cancer [26], laryngeal carcinoma [27] and nasopharyngeal carcinoma [28]. A recent study found that DCs isolated from tumors were also functionally impaired when compared to DCs from normal donors as measured by stimulation of the allogeneic mixed leukocyte reaction [29].…”