Prognostic significance of adenocarcinoma histology in women with cervical cancer

Galic, Vijaya; Herzog, Thomas J.; Lewin, Sharyn N.; Neugut, Alfred I.; Burke, William M.; Lu, Yu-Shiang; Hershman, Dawn L.; Wright, Jason D.

doi:10.1016/j.ygyno.2012.01.012

Cited by 230 publications

(201 citation statements)

References 22 publications

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“…Similarly, Shingleton et al (1995) reported that the survival according to histologic type was not significant in their study. Galic et al (2012) found that tumor histology significantly affects the outcomes of women with cervical cancer where adenocarcinoma type had negative impacts on survival for both early and advanced stage of cancer.…”

Section: Discussionmentioning

confidence: 99%

Estimating the Five-Year Survival of Cervical Cancer Patients Treated in Hospital Universiti Sains Malaysia

Razak

Khattak²,

Zubairi³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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Section: Discussionmentioning

confidence: 99%

Estimating the Five-Year Survival of Cervical Cancer Patients Treated in Hospital Universiti Sains Malaysia

Razak

Khattak²,

Zubairi³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…There is much interest in prognostic factors to permit more accurate patient stratification, that will improve clinical decision-making and may contribute to more rational treatment options. Current guidelines for cervical cancer recommend the same treatment regardless of histological subtype, although lower survival rates were reported for the adenocarcinoma subtype (4). Therefore increasing efforts should focus on prognosticators in adenocarcinoma of the uterine cervix.…”

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confidence: 99%

Prognostic Significance of Pre-treatment Serum C-Reactive Protein Level in Patients with Adenocarcinoma of the Uterine Cervix

Bodner‐Adler

Kimberger

Schneidinger

et al. 2016

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Cervical cancer is the third most common cancer in women worldwide, with peak incidence in the 40-to 45-year age group (1). Adenocarcinoma of the uterine cervix is a rare histological subtype, representing up to 20% of cervical carcinoma. International Federation of Gynaecology and Obstetrics (FIGO) stage, histological grade, tumour size, lymphovascular space invasion and lymph node metastasis are major prognostic factors reported in literature (1-3). Nevertheless, additional information guiding the patient's management would be helpful. There is much interest in prognostic factors to permit more accurate patient stratification, that will improve clinical decision-making and may contribute to more rational treatment options. Current guidelines for cervical cancer recommend the same treatment regardless of histological subtype, although lower survival rates were reported for the adenocarcinoma subtype (4). Therefore increasing efforts should focus on prognosticators in adenocarcinoma of the uterine cervix.C-Reactive protein (CRP) is widely used in clinical routine as the most important acute-phase serum protein for monitoring infection. CRP has also been shown to be elevated in patients with a variety of cancer types and an association with prognosis was found. Several studies have shown that patients with cancer have a higher level of circulating CRP than healthy controls prior to clinical diagnosis (5-8). In addition, an increase in serum CRP has been reported to be associated with poor prognosis in oesophageal, liver, colon and lung cancer (9-12). Elevated serum CRP levels have also been linked to impaired survival in patients with different gynaecological malignancies, including cervical, ovarian and endometrial cancer (13-15). However, only few studies reported on the prognostic role of CRP expression in cervical carcinoma (14, 16), with no data investigating exclusively the histological subtype adenocarcinoma of the uterine cervix.The aim of the present study was to evaluate whether the pre-treatment serum CRP level might be used as a prognostic parameter in patients with adenocarcinoma of the uterine cervix and to investigate a possible correlation between the serum CRP level and various clinicopathological parameters. 4691

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“…Multiple studies have shown that patients with adenocarcinoma have poorer response rate and survival rate in both early and advanced-stage carcinoma when compared to patients with squamous cell carcinoma [24][25]. The improved response rate in adenocarcinoma in the present study could indicate that a taxane-containing regimen might be more effective for non-squamous cell histology.…”

Section: Discussionmentioning

confidence: 49%

Phase II trial of paclitaxel, 13-cis retinoic acid, and interferon-alfa-2b in the treatment of advanced stage or recurrent cervical cancer

Song

Paola

Cracchiolo

et al. 2014

Gynecologic Oncology

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Prognostic significance of adenocarcinoma histology in women with cervical cancer

Cited by 230 publications

References 22 publications

Estimating the Five-Year Survival of Cervical Cancer Patients Treated in Hospital Universiti Sains Malaysia

Estimating the Five-Year Survival of Cervical Cancer Patients Treated in Hospital Universiti Sains Malaysia

Prognostic Significance of Pre-treatment Serum C-Reactive Protein Level in Patients with Adenocarcinoma of the Uterine Cervix

Phase II trial of paclitaxel, 13-cis retinoic acid, and interferon-alfa-2b in the treatment of advanced stage or recurrent cervical cancer

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