Prognostic significance of AgNOR Proliferative Index in gallbladder carcinoma - A potential alternative to frozen section analysis

Gupta, Sameer; Misra, Sanjeev

doi:10.4172/2167-0889.1000143

Cited by 1 publication

(2 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In the present study, AgNOR counts observed in chronic cholecystitis (2.44±0.31) were higher in comparison to Gupta et al and Gupta et al (1.89±0.96 and 2.08±0.37 and Misra et al (1.970.28). 2,8,9 In cases of hyperplasia, the average AgNOR count in the present study was lower than that found in studies by Gupta et al and Misra et al 7,8 However the mean AgNOR counts in carcinoma were higher in our study than that observed by Gupta et al and Misra et al but much less than those of Gupta et al though they had counted AgNORs separately in different grades of carcinoma. 2,7,8 Suzuki et al had found that mean AgNOR scores in carcinoma were low in comparison to other studies (3.28±1.38).…”

Section: Discussioncontrasting

confidence: 75%

“…2,8,9 In cases of hyperplasia, the average AgNOR count in the present study was lower than that found in studies by Gupta et al and Misra et al 7,8 However the mean AgNOR counts in carcinoma were higher in our study than that observed by Gupta et al and Misra et al but much less than those of Gupta et al though they had counted AgNORs separately in different grades of carcinoma. 2,7,8 Suzuki et al had found that mean AgNOR scores in carcinoma were low in comparison to other studies (3.28±1.38). 10 The increase in AgNOR counts from chronic cholecystitis to hyperplasia and hyperplasia to carcinoma were found to be statistically significant (p<0.05).…”

Section: Discussioncontrasting

confidence: 75%

See 1 more Smart Citation

Evaluation of AgNORs in gallbladder lesions

Kaushik¹,

Dattal²,

Gulati³

et al. 2017

Int J Res Med Sci

View full text Add to dashboard Cite

Background: Quantification of argyrophillic nucleolar organizer regions (AgNORs) is a good indicator of cellular proliferation activity and is useful diagnostic tool to estimate the malignant potential of lesions in gallbladder. The aim of the present study was to study the AgNORs and assess their correlation with various lesions of the gallbladder.Methods: This study was conducted in the department of pathology, Indira Gandhi Medical College, Shimla, Himachal Pradesh, India. One hundred specimens of gall bladder lesions (50 cases chronic cholecystitis,30 cases epithelial hyperplasia and 20 cases of carcinoma) were study subjects. AgNOR staining was done on three micron thin sections of paraffin embedded tissue, as per the method of Crocker and Smith with safranin counterstain. The number of AgNORs, stained as black dots was counted in one hundred adjacent cells in different lesions.Results: Mean AgNOR count in chronic cholecystitis, epithelial hyperplasia and carcinoma was 2.44±0.31, 3.88±0.39 and 7.90±0.76 respectively. AgNOR counts in various lesions gradually increased from chronic cholecystitis to carcinoma and the increase was statistically significant (p<0.05).Conclusions: Despite inter-laboratory variations and lack of standardization of counts for a particular lesion, AgNOR technique is easy to perform, economical and reliable indicator of malignant potential of the gall bladder lesions, hence can be used in resource poor set up as an adjunct to histopathology.

show abstract

Section: Discussioncontrasting

confidence: 75%