Prognostic significance of angiogenesis and immunoreactivity of cathepsin d and type IV collagen in high-grade stage T1 primary bladder cancer

Özer, Erdener; Mungan, Mehmet Uğur; Tuna, Burçin; Kazımoğlu, Hatem; Yörükoğlu, Kutsal; Kirkali, Ziya

doi:10.1016/s0090-4295(99)00026-6

Cited by 33 publications

(14 citation statements)

References 19 publications

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“…In distinct contrast to our results and those of other previous studies (13, 20, 21), however, Herrmann et al (15) reported that MVD count did not show any relationship to disease-free or overall survival, and these authors even suggested that MVD could be considered as a favorable prognostic sign. Chabannes et al (3) also found that all patients with lower MVD had a shorter survival time and, thus, confirm the consideration of MVD as a good prognostic factor.…”

Section: Discussioncontrasting

confidence: 99%

“…This is fully consonant with the observations by Ozer et al (20), who found that Grade III Stage pT1 bladder tumors have higher angiogenic activity and worse prognosis. Another study by Canoglu and coworkers (21) also confirmed that MVD in bladder carcinoma correlates with the tumor grade, stage, and its malignant potential thus substantiating the previous observations.…”

Section: Discussionsupporting

confidence: 91%

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Angiogenesis in urinary bladder carcinoma as defined by microvessel density (MVD) after immunohistochemical staining for Factor VIII and CD31

Gehani

Al-Kikhia

Mansuri³

et al. 2011

Libyan Journal of Medicine

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BackgroundAmong the patients with bladder cancer, a group is still at risk of disease recurrence, progression, and death from their cancer after curative treatment. Angiogenesis is a crucial pathogenic mechanism for this type of urothelial carcinoma and is a potential therapeutic target.ObjectivesTo quantify tumor angiogenesis in bladder cancer and determine whether it correlates with tumor stage and grade.Patients and methodsA series of 42 archival samples from carcinomas of the urinary bladder were graded, staged, and analyzed for microvessel density (MVD) by a double immunohistochemical technique using Factor VIII (FVIII) and CD31 antibodies. The correlation between MVD and histopathological grade and tumor stage was evaluated.ResultsFVIII and CD31 immunoreactivity was observed in 100% of cases and more intensely with CD31. Significantly higher MVD was determined in invasive tumors than in superficial tumors (p<0.05). MVD increased with tumor grade and stage (p<0.05); MVD was not affected by age or sex of the patients.ConclusionThese data demonstrate that MVD in bladder carcinoma correlates with the tumor grade and stage. Quantification of tumor angiogenesis may allow selection of the type of treatment for bladder cancer patients.

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionsupporting

confidence: 91%

Angiogenesis in urinary bladder carcinoma as defined by microvessel density (MVD) after immunohistochemical staining for Factor VIII and CD31

Gehani

Al-Kikhia

Mansuri³

et al. 2011

Libyan Journal of Medicine

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“…Daher et al investigated collagen IV staining pattern in a group of invasive cancers and found that widely absent or fragmented staining in more than 5% of a tumors predicted a worse short term survival (Daher et al 1987). Özer et al focused on high grade pT1 tumors and found that collagen IV did not play a role in predicting behavior (Özer et al 1999). It is difficult to assess if collagen IV can be helpful in evaluating the correct tumor stage, since it may be absent in urothelium with substantial superficial inflammation, a condition that can also accompany carcinoma in situ and papillary neoplasms (Deen et al 1994).…”

Section: Extracellular Matrix In Urothelial Bladder Cancermentioning

confidence: 99%

The Role of Structural Extracellular Matrix Proteins in Urothelial Bladder Cancer (Review)

Brunner

Tzankov

2007

Biomark�Insights

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The extracellular matrix (ECM) plays a key role in the modulation of cancer cell invasion. In urothelial carcinoma of the bladder (UC) the role of ECM proteins has been widely studied. The mechanisms, which are involved in the development of invasion, progression and generalization, are complex, depending on the interaction of ECM proteins with each other as well as with cancer cells. The following review will focus on the pathogenetic role and prognostic value of structural proteins, such as laminins, collagens, fibronectin (FN), tenascin (Tn-C) and thrombospondin 1 (TSP1) in UC. In addition, the role of integrins mediating the interaction of ECM molecules and cancer cells will be addressed, since integrin-mediated FN, Tn-C and TSP1 interactions seem to play an important role during tumor cell invasion and angiogenesis.

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“…Proliferating vascular endothelial cells in tumor tissues also highly express nestin and nestin is therefore considered to be closely related with tumor angiogenesis (Gravdal et al, 2009). Ozer et al reported in a previous study that T1 high grade bladder cancers possess higher angiogenetic activity resulting in a greater rate of progression or recurrence rates (Ozer et al, 1999). We hypothesized that nestin expression might have a role in predicting BCG response because of its association with tumor angiogenesis.…”

Section: Introductionmentioning

confidence: 89%

Prognostic Significance of Nestin Expression in pT1 High-Grade Bladder Urothelial Carcinoma Patients Treated with Intravesical BCG

Şen

Bozkurt²,

Demir³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Possible roles of nestin expression in terms of predicting intravesical BCG therapy response in T1 high grade bladder cancer patients were investigated. Materials and Methods: T1 high grade bladder cancer patients who were treated with intravesical BCG between 1990-2009 were included. Immunohistochemical staining for nestin expression was performed. Nestin(+) and nestin(-) patients were compared in terms of recurrence and progression rates. Results: Sixty-three patients were included and median follow-up time was twenty-five months. After staining; 33 patients (52.4%) were classified as nestin (+) and 30 (47.6%) as (-). Nestin (+) patients were more likely to recur compared to nestin (-) patients (60.6% vs. 30%, p<0.05). Progression rates were also higher in nestin (+) patients, although this result did not reach statistical significance (15.2 % vs. 10 %, p=0.710). Conclusions: Nestin expression, which seems effective in predicting recurrence, appears to have a potential role in the urothelial carcinoma tumorigenesis. Patients with high grade bladder cancer and positive nestin expression need close follow-up and might be informed about more tendency to recur. Further comprehensive studies including larger patient cohorts may clarify the role of nestin in bladder cancer.

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Prognostic significance of angiogenesis and immunoreactivity of cathepsin d and type IV collagen in high-grade stage T1 primary bladder cancer

Cited by 33 publications

References 19 publications

Angiogenesis in urinary bladder carcinoma as defined by microvessel density (MVD) after immunohistochemical staining for Factor VIII and CD31

Angiogenesis in urinary bladder carcinoma as defined by microvessel density (MVD) after immunohistochemical staining for Factor VIII and CD31

The Role of Structural Extracellular Matrix Proteins in Urothelial Bladder Cancer (Review)

Prognostic Significance of Nestin Expression in pT1 High-Grade Bladder Urothelial Carcinoma Patients Treated with Intravesical BCG

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