Prognostic significance of annexin II , human epididymis protein (HE-4) and claudin in endometrial carcinoma

Abstract

Introduction: Endometrial cancer (EC) is one of the most prevalent malignant tumors of the female reproductive system worldwide. Annexins are membrane binding proteins with important role in tumor development and progression. Human Epididymis Protein (HE-4) is a novel marker for gynecolgical tumors. Claudins are proteins of tight junction category playing an important role in cell adhesion and tumor spread.Material and methods: Seventy blocks of paraffin-embedded tissues of endometrial carcinoma cases. Immunohistochemical evaluation of Annexin II , HE- 4 and Claudin-7 staining was performed. Clinical follow-up to all cases was done every three months.Results: Positive Annexin II,HE-4 expression were observed in 88.6% and 77.1% of EC respectively. Significant correlation was found between expression of both Annexin II and HE-4 and FIGO stage, decreased both overall and disease free survival rates. Positive Claudin-7 expression was observed in 40% of EC, with significant correlation with high grade only, however, no correlation with other clinical parameters or survival analysis was detected.Conclusion: Annexin II, HE-4 and Claudin-7 are prognostic factors for endometrial carcinoma and could be used in molecular targeted therapy.

Prognostic values of human epididymis protein 4 expression in patients with endometrial cancer: A systematic review and meta‐analysis

“…The flow chart of literature screening is shown in Figure 1. among these studies, eight were from China, [7][8][9][10][11][12][13][14] four from Italy, [15][16][17][18] four from Poland, [19][20][21][22] three from Iran, [23][24][25] two from Australia, 26,27 two from Czech Republic, 28,29 two from Egypt, 30,31 two from Thailand, 32,33 two from The Netherlands, 34,35 two from Turkey, 36,37 and one each was from America, Austria, Denmark, India, Ireland, Slovenia, and Spain. [38][39][40][41][42][43][44] Thirty-three studies described the relationship between serum HE4 levels and the clinicopathological characteristics of EC, three studies described the relationship between tissue HE4 expression and the clinicopathological characteristics of EC, and two studies examined HE4 expression in both samples.…”