Prognostic significance of BAG-1 expression in nonsmall cell lung cancer

Gene silencing of BAG-1 modulates apoptotic genes and sensitizes lung cancer cell lines to cisplatin-induced apoptosis

“…The exact mechanism by which BAG-1 inhibits apoptosis is currently unknown, but BAG-1 has been shown to bind to a variety of cellular proteins to affect their functions. Increasing evidence demonstrates that BAG-1 is overexpressed in many tumor cell lines and tumor tissues 1,11,12 and in drug-resistant cancer cells. 13 In this study, we used siRNA to downregulate the expression of BAG-1 in the lung adenocarcinoma cell line A549 and found sensitization to cisplatin-induced apoptosis, supporting previous findings.…”

“…Given the role of BAG-1 in a number of different biological pathways, it is not surprising that deregulated BAG-1 expression is associated with carcinogenesis. 1,2 To further explore how BAG-1 mediates apoptosis in human lung cancer cells, we used RNA interference (RNAi) to knockdown the expression of BAG-1 in the human lung adenocarcinoma cell line A549. We correlated changes in gene expression by microarray with biological changes in tumor apoptosis and survival.…”

The nuclear BAG-1 isoform, BAG-1L, enhances oestrogen-dependent transcription

“…Alterations in BAG-1 expression occur in a variety of tumour types Tang et al, 1999;Yang et al, 1999a;Shindoh et al, 2000;Rorke et al, 2001;Turner et al, 2001;Yamauchi et al, 2001;Hague et al, 2002;Townsend et al, 2002), and BAG-1 overexpression may play an important role in breast cancer development. Here we show that BAG-1L is a potentially important regulator of the ERs, both in breast cancer cell lines and primary breast cancers.…”

Nuclear BAG-1 expression reflects malignant potential in colorectal carcinomas

“…Thus, it is reasonable to suppose that nuclear BAG-1 expression is closely related to the malignant potential. However, two papers reported that cytoplasmic BAG-1 expression represented a potential marker of improved survival in early-stage breast cancer patients (Turner et al, 2001) and nonsmall cell lung cancer patients (Rorke et al, 2001) whilst nuclear BAG-1 expression was not related to the malignant potential. It is likely that the discrepancy between results may be attributed to different antibody or organ specificity.…”