Prognostic significance of biologic factors in squamous cell carcinoma of the esophagus

Ikeda, Goh; Isaji, Shuji; Das, Bidhan Chandra; Watanabe, Masatoshi; Kawarada, Yoshifumi

doi:10.1002/(sici)1097-0142(19991015)86:8<1396::aid-cncr3>3.0.co;2-h

Cited by 69 publications

(50 citation statements)

References 34 publications

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“…In a number of studies, the prognostic significance of biological factors such as oncogenes, tumoursuppressor genes and growth factors has been studied. Overexpression of p53, p21 and vascular endothelial growth factor has been identified as prognostic factors by some authors (Ikeda et al, 1999;Shimada et al, 2000), but the results of these studies are not always consistent and therefore these factors are currently not used in daily routine. Prognostic factor analyses in patients with locally advanced or metastatic oesophageal cancer treated with chemotherapy are scarce.…”

Section: Discussionmentioning

confidence: 99%

Prognostic factors for survival in patients with advanced oesophageal cancer treated with cisplatin-based combination chemotherapy

et al. 2003

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The objective of this study was to identify prognostic factors for survival in patients with advanced oesophageal cancer, who are treated with cisplatin-based combination chemotherapy. We analysed the baseline characteristics of 350 patients who were treated in six consecutive prospective trials with one of the following regimens: cisplatin/etoposide, cisplatin/etoposide/5-fluorouracil, cisplatin/paclitaxel (weekly) and cisplatin/paclitaxel (biweekly). Predictive factors in univariate analyses were further evaluated using multivariate analysis (Cox regression). The median survival of all patients was 9 months. The 1, 2 and 5-year survival rates were 33, 12 and 4%, respectively. The main prognostic factors were found to be WHO performance status (0 or 1 vs 2), lactate dehydrogenase (normal vs elevated), extent of disease (limited disease defined as locoregional irresectable disease or lymph node metastases confined to either the supraclavicular or celiac region vs extensively disseminated disease) in addition to the type of treatment (weekly or biweekly cisplatin/paclitaxel regimen vs 4-weekly cisplatin/etoposide with or without 5-fluorouracil). Although weight loss, liver metastases and alkaline phosphatase were significant prognostic factors in univariate analyses, these factors lost their significance in multivariate analyses. The median survival for patients without any risk factors was 12 months, compared to only 4 months in patients with WHO 2 plus elevated LDH and extensive disease. The performance status, extent of disease, LDH and the addition of paclitaxel to cisplatin are independent prognostic factors in patients with advanced oesophageal cancer, who are treated with cisplatin-based combination chemotherapy.

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Section: Discussionmentioning

confidence: 99%

Prognostic factors for survival in patients with advanced oesophageal cancer treated with cisplatin-based combination chemotherapy

et al. 2003

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“…Several studies suggested that the survival rate correlates with biological factors such as the expression of p53 (3), cyclin D1 (4), and Ki-67 (5,6) or with clinicopathologic factors such as tumor size and lymph node status (6,7). However, whether these factors can be used as prognostic indicators is still controversial, although they appear to be involved in the carcinogenesis of ESCC (6,8,9). With the development of cDNA microarray technology, it has recently become possible to screen for alterations in the expression of many genes simultaneously (10).…”

Section: Introductionmentioning

confidence: 99%

Mina53 as a Potential Prognostic Factor for Esophageal Squamous Cell Carcinoma

Tsuneoka

Fujita

Arima

et al. 2004

Clinical Cancer Research

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Purpose: We previously identified mina53, a novel Myc target gene. Here we investigated whether mina53 is related to esophageal squamous cell carcinoma (ESCC), a disease with poor prognosis.Experimental Design: Mina53 expression was suppressed in ESCC cell lines by a RNA interference method to investigate whether Mina53 is involved in cell proliferation. Expression of Mina53 was investigated by Western blotting in tissue sections from patients with ESCC. Immunohistochemical analysis of Mina53 was carried out and compared with that using anti-Ki-67 antibody. Finally, the level of Mina53 expression was compared with the length of survival of patients with ESCC.Results: Reduction of mina53 expression by RNA interference suppressed cell proliferation in ESCC cell lines. Western blot analysis of surgically resected ESCC specimens indicated that the expression of Mina53 in tumors was increased compared with that in adjacent nonneoplastic tissues in all four specimens examined. When formalin-fixed specimens from 52 patients with ESCC were stained immunohistochemically, it was found that Mina53 was highly expressed in 83% of specimens. Anti-Mina53 antibody stained tumors more efficiently than antibody against Ki-67, a cell proliferation biomarker, in some cancer specimens. Patients with high expression of Mina53 had shorter survival periods, whereas the expression level of Ki-67 in ESCC showed no relationship to patient outcome. Conclusions:Taken together, our results indicate that expression of Mina53 is a characteristic feature of ESCC and suggest that immunostaining by anti-Mina53 antibody may be useful as a potential prognostic indicator.

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“…Although the presence of mutant p53 have shown to be correlated with the poor prognosis [163,164], other studies have not found such correlation [165,166]. It has also been shown that measurement of circulating anti p53 antibody in serum of patients with SCCE is useful for detection of p53 mutations, and as a tumor marker or prognostic marker [167][168][169].…”

Section: P53mentioning

confidence: 99%

Growth Factors, Signal Transduction Pathways, and Tumor Suppressor Genes in Esophageal Cancer

Zare¹,

Moghanibashi²,

Jazii³

2012

Esophageal Cancer - Cell and Molecular Biology, Biomarkers, Nutrition and Treatment

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Prognostic significance of biologic factors in squamous cell carcinoma of the esophagus

Cited by 69 publications

References 34 publications

Prognostic factors for survival in patients with advanced oesophageal cancer treated with cisplatin-based combination chemotherapy

Prognostic factors for survival in patients with advanced oesophageal cancer treated with cisplatin-based combination chemotherapy

Mina53 as a Potential Prognostic Factor for Esophageal Squamous Cell Carcinoma

Growth Factors, Signal Transduction Pathways, and Tumor Suppressor Genes in Esophageal Cancer

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