Prognostic significance of bone marrow micrometastases in patients with gastric cancer.

Jauch, K.-W.; Heiss, M. M.; Gruetzner, Uwe; Funke, I.; Pantel, Klaus; Babic, Rudolf; Eissner, Hans-Joachim; Riethmüeller, Gert; Schildberg, F. W.

doi:10.1200/jco.1996.14.6.1810

Cited by 167 publications

(96 citation statements)

References 28 publications

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“…While statistically significant correlations with undifferentiated histology and/or more advanced depth of tumour invasion were found in some studies (Schlimok et al, 1991;O'Sullivan et al, 1995;Maehara et al, 1996;, in others Jauch et al, 1996;Schott et al, 1998;Bonavina et al, 2001), as well in ours, there was no correlation.…”

Section: Cytokeratin-positive Cells In Bone Marrow Of Gastric Cancer contrasting

confidence: 41%

“…Clinical outcome in gastric cancer has been reported to be affected by the presence of bone marrow infiltration in two studies (Schlimok et al, 1991;Jauch et al, 1996). While in the report by Schlimok et al, 1991 only 38 R0 patients were evaluated, in the recent study by Jauch et al, 1996, the survival was analysed in 109 R0 patients.…”

Section: Cytokeratin-positive Cells In Bone Marrow Of Gastric Cancer mentioning

confidence: 99%

“…While in the report by Schlimok et al, 1991 only 38 R0 patients were evaluated, in the recent study by Jauch et al, 1996, the survival was analysed in 109 R0 patients. In the latter study, the detection of more than three tumour cells in bone marrow was associated with poorer survival particularly in N0 and T1/T2 subsets.…”

Section: Cytokeratin-positive Cells In Bone Marrow Of Gastric Cancer mentioning

confidence: 99%

“…Bone marrow micrometastases have been found in over onequarter of patients undergoing curative resection of gastrointestinal cancer (O'Sullivan et al, 1995) and according to some authors they affected prognosis (Schlimok et al, 1991;Jauch et al, 1996). However the independent prognostic significance of isolated tumour cells in bone marrow is still a matter of debate and remains to be substantiated (Funke and Schraut, 1998;Hermanek et al, 1999).…”

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The presence of bone marrow cytokeratin-immunoreactive cells does not predict outcome in gastric cancer patients

et al. 2002

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The independent prognostic significance of isolated tumour cells in bone marrow is still a matter of debate. This study evaluated the possible association of bone marrow micrometastases with tumour progression and prognosis in patients affected by gastric cancer. Bone marrow aspirates from both iliac crests were obtained from 114 consecutive patients operated on for gastric cancer. The specimens were stained with monoclonal antibody CAM 5.2 which reacts predominantly with cytokeratin filaments 8 and 19. Among 114 cases analysed, 33 cases (29%) had cytokeratine-positive cells in the bone marrow. There was no significant relationship between the presence of bone marrow micrometastases and site, depth of tumour invasion, lymph node metastases, presence of metastases. Patients with cytokeratine-positive cells had a trend towards a diffuse type histology (P=0.06). Among the 88 curatively resected patients, median survivals were 40 months and 36 months for cytokeratine-negative and cytokeratine-positive subsets respectively (P=0.9). Recurrence of the disease was observed in 39 cases (44.3%); 11 of 24 (45.8%) in the cytokeratine-positive subset and 28 of 64 (43.7%) in the cytokeratine-negative subset. In conclusion in our experience the presence of cytokeratine-positive cells in the bone marrow of curatively resected gastric cancer patients did not affect outcome and its independent prognostic significance remains to be proven before its official acceptance in the TNM classification.

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Section: Cytokeratin-positive Cells In Bone Marrow Of Gastric Cancer contrasting

confidence: 41%

Section: Cytokeratin-positive Cells In Bone Marrow Of Gastric Cancer mentioning

confidence: 99%

Section: Cytokeratin-positive Cells In Bone Marrow Of Gastric Cancer mentioning

confidence: 99%

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The presence of bone marrow cytokeratin-immunoreactive cells does not predict outcome in gastric cancer patients

et al. 2002

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“…Histological tumour type was determined according to the Lauren classification and the degree of tumour cell differentiation (grading) was also assessed (Roder et al, 1993). Lymphatic and blood vessel invasion and the presence of tumour cells in bone marrow, which are proposed as new prognostic factors (Maehara et al, 1995;Jauch et al, 1996), were also considered. Data for these three parameters were not available for all patients.…”

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confidence: 99%

The Rhesus D-negative phenotype is an independent predictor of poor prognosis in curatively (RO) resected gastric cancer patients

Mayer¹,

Schraut²,

Funke³

et al. 1997

Br J Cancer

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Summary Among gastric cancer patients, the Rhesus D-negative phenotype correlated with increased tumour recurrence [all patients, n= 83, P = 0.026; curatively (RO) resected patients, n = 51, P = 0.093] and reduced overall survival time (all patients, log-rank P = 0.0028; RO patients, log-rank P= 0.0003) and was identified in multivariate analysis as the most important independent prognostic marker in the R0 patient group (relative risk 9.1, P= 0.0013).Keywords: gastric cancer; Rhesus factor; progression; prognosis; multivariate analysis Identification of high-risk cancer patients and the development of prognosis-oriented, multimodal therapy adapted to the individual patient is one of the main goals of current oncological research. Towards this end, much effort is currently being directed towards the identification of new, independent prognostic parameters often employing laborious molecular biological and immunohistological approaches. In gastric cancer, a variety of cell adhesion molecules, secreted products and gene-regulatory proteins have been identified as potential risk factors (Tahara, 1995). Among the factors that are readily determined in tumour patients receiving surgical treatment are the blood group antigens. In contrast to extensive studies on the ABO system, the prognostic relevance of the Rhesus factor has only been sporadically investigated (Halvorsen, 1986;Cerny et al, 1987;Kvist et al, 1990Kvist et al, , 1992 Bryne et al, 1991a, b; Raitanen and Tammela, 1993) (1992). Tumour localization and tumour diameter were determined and gross appearance of the tumour was evaluated according to the Borrmann classification. Histological tumour type was determined according to the Lauren classification and the degree of tumour cell differentiation (grading) was also assessed (Roder et al, 1993). Lymphatic and blood vessel invasion and the presence of tumour cells in bone marrow, which are proposed as new prognostic factors (Maehara et al, 1995;Jauch et al, 1996), were also considered. Data for these three parameters were not available for all patients.Prospective follow-up was routinely performed every 6 months and considered tumour recurrence and overall survival. In RO patients, local and distant tumour relapse were evaluated, while in R1 patients distant metastases only were considered. In patients with macroscopic residual tumour (R2) tumour recurrence was not evaluated. Overall survival data were available for all patients.Statistical analyses were performed using the Fisher's exact probability test (two-tailed)

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Molecular detection of low-level disease in patients with cancer

Burchill¹,

Selby²

2000

J. Pathol.

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Prognostic significance of bone marrow micrometastases in patients with gastric cancer.

Cited by 167 publications

References 28 publications

The presence of bone marrow cytokeratin-immunoreactive cells does not predict outcome in gastric cancer patients

The presence of bone marrow cytokeratin-immunoreactive cells does not predict outcome in gastric cancer patients

The Rhesus D-negative phenotype is an independent predictor of poor prognosis in curatively (RO) resected gastric cancer patients

Molecular detection of low-level disease in patients with cancer

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