Prognostic Significance of C-reactive Protein-to-prealbumin Ratio in                    Patients with Esophageal Cancer

Matsunaga, Tomoyuki; Miyata, Hiroshi; Sugimura, Keijiro; Motoori, Masaaki; Asukai, Kei; Yanagimoto, Yoshitomo; Yamamoto, Keiji; Akita, Hirofumi; Nishimura, Junichi; Wada, Hiroshi; Takahashi, Hidenori; Yasui, Masayoshi; Omori, Takeshi; Ohue, Masayuki; Fujiwara, Yoshiyuki; Yano, Masahiko

doi:10.33160/yam.2020.02.002

“…Importantly, the GNRI can be easily calculated from routine hematological data including serum albumin, height, and weight. These readily available parameters can reflect the survival risk in various cancers and have demonstrated utility in elderly patients [17,20].…”

Section: Introductionmentioning

confidence: 99%

Impact of geriatric nutritional risk index on outcomes after gastrectomy in elderly patients with gastric cancer: a retrospective multicenter study in Japan

Matsunaga

¹

,

Saito²,

Osaki

³

et al. 2022

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Background Several studies investigated the utility of inflammation and nutritional markers in predicting the prognosis in patients with gastric cancer; however, the markers with the best predictive ability remain unclear. This retrospective study aimed to determine inflammation and nutritional markers that predicted prognosis in elderly patients over 75 years of age undergoing curative gastrectomy for gastric cancer. Methods Between January 2005 and December 2015, 497 consecutive elderly gastric cancer patients aged over 75 years underwent curative gastrectomy in 12 institutions. The geriatric nutritional risk index (GNRI), prognostic nutritional index, neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, and C-reactive protein/albumin ratio were examined as prognostic markers for overall survival (OS) and disease-specific survival (DSS) using area under the curve (AUC) using receiver operating characteristic (ROC) curve analysis. Results The GNRI had the highest AUC and predictive value for both OS (0.637, p < 0.001) and DSS (AUC 0.645, p < 0.001). The study cohort was categorized into the high and low GNRI groups based on the optimal GNRI cut-off values for OS (97.0) and DSS (95.8) determined with the ROC analysis. For both OS and DSS, there was a significant correlation between the GNRI and several clinicopathological factors including age, body mass index, albumin, American Society of Anesthesiologists physical status score, depth of tumor invasion, lymph node metastasis, lymphatic invasion, pathological stage, operation duration, bleeding, procedure, approach, death due to primary disease, and death due to other disease. The GNRI remained a crucial independent prognostic factor for both OS (Hazard ratio [HR] = 1.905, p < 0.001) and DSS in multivariate analysis (HR = 1.780, p = 0.043). Conclusions Among a panel of inflammation and nutritional markers, the GNRI exhibited the best performance as a prognostic factor after curative gastrectomy in elderly patients with gastric cancer, indicating its utility as a simple and promising index for predicting OS and DSS in these patients.

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“…Some researchers suggested that CRP/PAlb was more sensitive to CRP/Alb for cancer prognosis. High CRP/ Alb or CRP/PAlb ratio was significantly associated with bad prognosis [36]. Our results showed that patients who only accepted enteral nutrition had a decreasing trend in the CRP level, but not in the ratio of CRP/Alb and CRP/PAlb.…”

Section: Discussionmentioning

confidence: 46%

Enteral Nutrition Combined with Improved-Sijunzi Decoction Shows Positive Effect in Precachexia Cancer Patients: A Retrospective Analysis

Li

¹

,

Chen

²

,

Zeng

³

et al. 2021

Evidence-Based Complementary and Alternative Medicine

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Background. Cancer has been considered as the leading cause of death in the world. In patients with cancer, up to 80% display a cachectic period after diagnosis. Cachexia is known to have a negative impact on function, treatment tolerance, higher rates of hospitalizations, and mortality. Anorexia is often used as a warning sign of precachexia. Long-term anorexia may lead to malnutrition and, then, accelerate the occurrence of cachexia. A safe and effective treatment, which can both improve appetite and assist nutritional support for precachexia cancer patients shows its particular important role. Methods. A retrospective analysis comparing the different therapeutic effects on precachexia cancer patients with anorexia-malnutrition. We recorded 46 patients with the improved-Sijunzi decoction combined with enteral nutrition emulsion (ISJZ group) and 35 patients with single enteral nutrition emulsion (SEN group). The different therapeutic effects of the two groups were observed by recording indicators before and 2 weeks after treatment, including patient-generated subjective global assessment score, quality of life score, Karnofsky performance status scale, Eastern cooperative oncology group scale standard and traditional Chinese medicine syndrome, daily total dietary intake, red blood cells, hemoglobin, prealbumin, albumin, total protein cholinesterase, C-reactive protein, leukocytes, alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase, urea nitrogen, and creatinine. Results. ISJZ group exhibited prominent improvement of traditional Chinese medicine syndrome (TCMS), nutritional condition, and quality of life compared with the SEN group (QOL: p = 0.0001 , PG-SGA: p = 0.019 , dietary intake: p = 0.0001 , TCMS: p = 0.0001 ). The levels of HGB ( p = 0.006 ), PAlb ( p = 0.001 ), Alb ( p = 0.0001 ), TP ( p = 0.008 ), and ChE ( p = 0.0001 ) in the ISJZ group were higher than the SEN group after treatment. Moreover, the ratios of CRP/ALB ( p = 0.028 ) and CRP/PALB ( p = 0.005 ) in the two groups have obvious differences; they were lower for the ISJZ group than the SEN group. Conclusions. Enteral nutrition combined with ISJZ decoction is an effective treatment in precachexia cancer patients for the prevention of cachexia. This treatment therapy can alleviate the inflammatory response, improve malnutrition state, and promote the performance status. Tianjin Medical University Cancer Institute and Hospital approved this study (Trial No. 1913).

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“…Besides, PAB is an acute phase reactive protein able to not only effectively evaluate the synthetic ability of the liver, but also reflect the severity of inflammatory response in patients with cardiovascular disease [13] . Matsunaga et al [14] found that the content of PAB in the peripheral blood of patients with unstable angina pectoris is far lower than that in normal people. In this study, the content of hs-CRP and PAB in the peripheral blood of MI patients was detected.…”

Section: Discussionmentioning

confidence: 98%

Associations of serum high-sensitivity C-reactive protein and prealbumin with coronary vessels stenosis determined by coronary angiography and heart failure in patients with myocardial infarction

Zhu¹,

Yu²,

Xu³

et al. 2023

J Med Biochemistry

2

0

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Background: To explore the associations of serum high-sensitivity C-reactive protein (hs-CRP) and prealbumin (PAB) with the number of diseased coronary vessels, degree of stenosis and heart failure in patients with myocardial infarction (MI). Methods: A total of 39 MI patients treated in the Cardiology were selected as the observation group, and another 41 patients with normal results of coronary angiography during the same period were selected as the control group. The general data of patients were recorded in detail, the content of serum hs-CRP and PAB in the peripheral blood was detected, and the number of diseased coronary vessels and the degree of stenosis were detected via coronary angiography. Results: Compared with those in control group, the blood pressure and heart rate significantly rose, the content of indexes related to the severity of MI were significantly increased, the content of hs-CRP was significantly increased, and the content of PAB was significantly decreased in observation group. Hs-CRP was positively correlated with the number of diseased coronary vessels, degree of stenosis and heart failure in patients, but PAB was negatively correlated with the above factors. The survival rate of MI patients with high content of hs-CRP was obviously lower than that of patients with low content of hs-CRP. Conclusion: Serum hs-CRP and PAB are closely associated with the number of diseased coronary vessels, degree of stenosis and heart failure in MI patients.

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Prognostic Significance of C-reactive Protein-to-prealbumin Ratio in Patients with Esophageal Cancer

Cited by 19 publications

References 41 publications

Impact of geriatric nutritional risk index on outcomes after gastrectomy in elderly patients with gastric cancer: a retrospective multicenter study in Japan

Impact of geriatric nutritional risk index on outcomes after gastrectomy in elderly patients with gastric cancer: a retrospective multicenter study in Japan

Enteral Nutrition Combined with Improved-Sijunzi Decoction Shows Positive Effect in Precachexia Cancer Patients: A Retrospective Analysis

Associations of serum high-sensitivity C-reactive protein and prealbumin with coronary vessels stenosis determined by coronary angiography and heart failure in patients with myocardial infarction

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