Prognostic significance of carbonic anhydrase IX expression by cancer‐associated fibroblasts in lung adenocarcinoma

Abstract

The physical aging of the epoxy network consisting of a diglycidyl ether of bisphenol A, m‐xylylenediamine, and polyetherimide was studied by differential scanning calorimetry. The glass transition temperature and the variation of the specific heat capacities have been calculated using the method, based on the intersection of both enthalpy–temperature lines for glassy and liquid states. The apparent activation energy (EH) was calculated using a single method that involved separate temperature and excess enthalpy dependency. All calorimetric data were compared with those obtained for the epoxy network without thermoplastic. thermoplastic. © 2007 Wiley Periodicals, Inc. J Appl Polym Sci 103: 3931–3935, 2006

Expression of a Hypoxia-Associated Protein, Carbonic Anhydrase-9, Correlates with Malignant Phenotypes of Gastric Carcinoma

“…Gastric cancer with hypoxic conditions might be associated with more aggressive tumor phenotypes, which may indicate a poorer prognosis for patients. A previous study reported that CA-9 expression by cancer-associated fibroblasts was a better predictor of outcome than that by cancer cells, and provides new insights into the biologic significance of cancer-associated fibroblasts in the hypoxic microenvironment of the lung adenocarcinoma [20]. In our study, however, CA-9 expression by cancer-associated fibroblasts was not a significant predictive marker in 265 cases of gastric cancer (data not shown).…”

Prognostic relevance of carbonic anhydrase IX expression is distinct in various subtypes of breast cancer and its silencing suppresses self-renewal capacity of breast cancer cells

“…Moreover, the proportion of CAIX-positive stroma cells has been found to differ among BC subtypes [42]. Interestingly, CAIX expression by cancer-associated fibroblasts has been found to be a better predictor of outcome than its expression by cancer cells in patients with lung cancer [43], while in prostate cancer, it has been found to drive epithelial-mesenchymal transition in cancer cells [44].…”

Cancer-associated-fibroblasts and tumour cells: a diabolic liaison driving cancer progression

“…Other proteins expressed by stromal fibroblasts have been shown to have a prognostic value for solid tumours. In particular, a poor prognosis has been associated with expression in CAFs of p53 tumour suppressor in ductal carcinoma [10], or the hypoxia marker carbonic anidrase IX in human lung adenocarcinoma [11], or periostin in cholangiocarcinoma [12]. On the contrary, the expression of caveolin-1, PTEN or podoplanin in tumour stroma correlates with a favourable prognosis for several cancers [13][14][15].…”