Prognostic significance of caspase-3 expression in primary resected esophageal squamous cell carcinoma

Hsia, Jiun-Yi; Chen, Chih Yi; Chen, Jung Ta; Hsu, Chiao Po; Shai, Sen‐Ei; Yang, Shih-Chieh; Chuang, Chun‐Yi; Wang, Pei Yen; Miaw, Jen

doi:10.1053/ejso.2002.1338

Cited by 57 publications

(70 citation statements)

References 9 publications

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“…Though caspase-3 is one of the most important molecules in the apoptosis cascade, studies of it in terms of lung cancer outcome have been limited. Several studies of caspase-3 expression have shown conflicting effects on survival [48][49][50]. Our study indicates that the total amount of caspase-3 expression was important for its function in NSCLC tissues, although the activity of the protein remains unclear.…”

mentioning

confidence: 66%

A multiple marker analysis of apoptosis-associated protein expression in non-small cell lung cancer in a Chinese population

Fan

Xu²,

Lin³

et al. 2011

Folia Histochem Cytobiol.

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mentioning

confidence: 66%

A multiple marker analysis of apoptosis-associated protein expression in non-small cell lung cancer in a Chinese population

Fan

Xu²,

Lin³

et al. 2011

Folia Histochem Cytobiol.

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“…Expression of survivin, an apoptosis inhibitor targeting caspase 3 and caspase 7, was found elevated in OSCC tissue 71, 72, whereas caspase 3 expression level is decreased 72. Consistently, caspase 3 is found associated with a favorable prognosis for primary resected ESCC patients 73, whereas survivin expression was proposed as negative prognostic factor of OSCC 74. However, different roles of caspase 3 in OSCC are also suggested.…”

Section: Notch Signaling In Head and Neck Squamous Cell Carcinoma (Hnmentioning

confidence: 87%

Does Notch play a tumor suppressor role across diverse squamous cell carcinomas?

et al. 2016

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The role of Notch pathway in tumorigenesis is highly variable. It can be tumor suppressive or pro‐oncogenic, typically depending on the cellular context. Squamous cell carcinoma (SCC) is a cancer of the squamous cell, which can occur in diverse human tissues. SCCs are one of the most frequent human malignancies for which the pathologic mechanisms remain elusive. Recent genomic analysis of diverse SCCs identified marked levels of mutations in NOTCH1, implicating Notch signaling pathways in the pathogenesis of SCCs. In this review, evidences highlighting NOTCH's role in different types of SCCs are summarized. Moreover, based on accumulating structural information of the NOTCH receptor, the functional consequences of NOTCH1 gene mutations identified from diverse SCCs are analyzed, emphasizing loss of function of Notch in these cancers. Finally, we discuss the convergent view on an intriguing possibility that Notch may function as tumor suppressor in SCCs across different tissues. These mechanistic insights into Notch signaling pathways will help to guide the research of SCCs and development of therapeutic strategies for these cancers.

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“…Because NK cells are often recruited to sites of inflammation including the tumor microenvironment (14), and clinically tumor infiltrating NK cells have been associated with improved prognosis in a range of different tumor cell types (44,45), treatments which can activate intratumoral NK cells may show additional, immune-mediated activity.…”

Section: Discussionmentioning

confidence: 99%

Reovirus Activates Human Dendritic Cells to Promote Innate Antitumor Immunity

Errington

Steele

Prestwich

et al. 2008

The Journal of Immunology

161

175

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Oncolytic viruses can exert their antitumor activity via direct oncolysis or activation of antitumor immunity. Although reovirus is currently under clinical investigation for the treatment of localized or disseminated cancer, any potential immune contribution to its efficacy has not been addressed. This is the first study to investigate the ability of reovirus to activate human dendritic cells (DC), key regulators of both innate and adaptive immune responses. Reovirus induced DC maturation and stimulated the production of the proinflammatory cytokines IFN-α, TNF-α, IL-12p70, and IL-6. Activation of DC by reovirus was not dependent on viral replication, while cytokine production (but not phenotypic maturation) was inhibited by blockade of PKR and NF-κB signaling. Upon coculture with autologous NK cells, reovirus-activated DC up-regulated IFN-γ production and increased NK cytolytic activity. Moreover, short-term coculture of reovirus-activated DC with autologous T cells also enhanced T cell cytokine secretion (IL-2 and IFN-γ) and induced non-Ag restricted tumor cell killing. These data demonstrate for the first time that reovirus directly activates human DC and that reovirus-activated DC stimulate innate killing by not only NK cells, but also T cells, suggesting a novel potential role for T cells in oncolytic virus-induced local tumor cell death. Hence reovirus recognition by DC may trigger innate effector mechanisms to complement the virus’s direct cytotoxicity, potentially enhancing the efficacy of reovirus as a therapeutic agent.

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Prognostic significance of caspase-3 expression in primary resected esophageal squamous cell carcinoma

Cited by 57 publications

References 9 publications

A multiple marker analysis of apoptosis-associated protein expression in non-small cell lung cancer in a Chinese population

A multiple marker analysis of apoptosis-associated protein expression in non-small cell lung cancer in a Chinese population

Does Notch play a tumor suppressor role across diverse squamous cell carcinomas?

Reovirus Activates Human Dendritic Cells to Promote Innate Antitumor Immunity

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