Prognostic Significance of Circulating IL-10 and IL-6 Serum Levels in Colon Cancer Patients Undergoing Surgery

Galizia, Gennaro; Orditura, Michele; Romano, Ciro; Lieto, Eva; Castellano, Paolo; Pelosio, Luigi; Imperatore, Vincenzo; Catalano, Giuseppe; Pignatelli, Carlo; Vita, Ferdinando De

doi:10.1006/clim.2001.5163

Cited by 203 publications

(139 citation statements)

References 18 publications

Supporting

Mentioning

125

Contrasting

Unclassified

Order By: Relevance

“…However, it was of interest that, in their study, the median concentrations of interleukin-6 and interleukin-10, before surgery, were higher (8 and 15 pg ml À1 , respectively) compared with the results (3 and 5 pg ml À1 , respectively) in the present study. Nevertheless, consistent with the present study Galizia et al (2002) observed that the majority of patients did not normalise their cytokine concentrations following radical resection. The basis of the discrepancies between the present and previous studies is not clear.…”

Section: Discussionsupporting

confidence: 91%

“…However, in the present study, when the analysis was confined to those patients with stage I disease, neither C-reactive protein, interleukin-6 or interleukin-10 appeared to normalise on resection of the primary tumour. Galizia et al (2002) in a similar study design in 50 patients with colon reported that that both interleukin-6 and interleukin-10 concentrations fell by day 16 following resection. However, it was of interest that, in their study, the median concentrations of interleukin-6 and interleukin-10, before surgery, were higher (8 and 15 pg ml À1 , respectively) compared with the results (3 and 5 pg ml À1 , respectively) in the present study.…”

Section: Discussionmentioning

confidence: 90%

See 1 more Smart Citation

The longitudinal relationship between circulating concentrations of C-reactive protein, interleukin-6 and interleukin-10 in patients undergoing resection for renal cancer

et al. 2006

View full text Add to dashboard Cite

The systemic inflammatory response, as evidenced by elevated circulating concentrations of C-reactive protein, is a stageindependent prognostic factor in patients undergoing curative nephrectomy for localised renal cancer. However, it is not clear whether the systemic inflammatory response arises from the tumour per se or as a result of an impaired immune cytokine response. The aim of the present study was to examine C-reactive protein, interleukin-6 and interleukin-10 concentrations before and following curative resection of renal cancer. Sixty-four patients with malignant renal disease and 12 with benign disease, undergoing resection were studied. Preoperatively, a blood sample was collected for routine laboratory analysis with a further sample stored before analysis of interleukin-6 and interleukin-10 using an enzyme-linked immunosorbent assay (ELISA) technique. The blood sampling procedure and analyses were repeated at approximately 3 months following resection. Circulating concentrations of both interleukin-6 and interleukin (Pp0.01) were higher and a greater proportion were elevated (Po0.05) in malignant compared with benign disease. The renal cancer patients were grouped according to whether they had evidence of a systemic inflammatory response. In the inflammatory group T stage was higher (Po0.01), both interleukin-6 and interleukin-10 concentrations were higher (Po0.001) and elevated (Po0.10) compared with the non-inflammatory group. Tumour volume was weakly correlated with C-reactive protein (r 2 ¼ 0.20, P ¼ 0.002), interleukin-6 (r 2 ¼ 0.20, P ¼ 0.002) and interleukin-10 (r 2 ¼ 0.24, P ¼ 0.001). Following nephrectomy the proportion of patients with elevated C-reactive protein, interleukin-6 and interleukin-10 concentrations did not alter significantly. An elevated preoperative C-reactive protein was associated with increased tumour stage, interleukin-6 and interleukin-10 concentrations. However, resection of the primary tumour did not appear to be associated with significant normalisation of circulating concentrations of C-reactive protein, interleukin-6 or interleukin-10. Therefore, the presence of systemic inflammatory response is unlikely to be solely be determined by the tumour itself, but may be as a result of an impaired immune cytokine response in patients with renal cancer.

show abstract

Section: Discussionsupporting

confidence: 91%

Section: Discussionmentioning

confidence: 90%

The longitudinal relationship between circulating concentrations of C-reactive protein, interleukin-6 and interleukin-10 in patients undergoing resection for renal cancer

et al. 2006

View full text Add to dashboard Cite

show abstract

“…Already published data have presented contradictory results Table 1. Cytokine levels (TNF-α, IL-1β, IL-6, IL-8, IL-10) in sera of the healthy subjects and patients with UC, CD, or CRC related to preoperative serum IL-10 levels in CRC patients, pointing to a relationship between higher IL-10 levels and an inoperable tumor (Galizia et al 2002;Kamiñska et al 2000). On the other hand, our study was conducted in patients with operable CRC (Dukes' stage B), which may explain the contradictions.…”

Section: Discussionmentioning

confidence: 97%

Proinflammatory cytokines and IL-10 in inflammatory bowel disease and colorectal cancer patients

Szkaradkiewicz

Marciniak

Chudzicka-Strugała

et al. 2009

Arch. Immunol. Ther. Exp.

114

View full text Add to dashboard Cite

Introduction: The aim of the study was to describe the levels of circulating monocyte/macrophage pro-inflammatory cytokines (TNF-α, IL-1β, IL-6, and IL-8) and an anti-inflammatory cytokine (IL-10) in inflammatory bowel disease (IBD) and colorectal cancer (CRC) patients and healthy controls. Materials and Methods:The study was conducted on 15 healthy individuals, 20 patients with ulcerative colitis (UC), 12 with Crohn's disease (CD), and 15 with CRC (Dukes' stage B). Blood serum cytokine levels were measured by ELISA. Results: The patients with UC had significantly higher levels of the pro-inflammatory cytokines and of circulating IL-10 than the healthy controls. The patients with CD and CRC had the same specific pattern of serum cytokines of significantly elevated levels of the pro-inflammatory cytokines, but the IL-10 levels were within the range found in the healthy individuals. Conclusions: Thus our results demonstrate that both IBD and CRC are linked with an intensified production of a wide array of monocyte/macrophage pro-inflammatory cytokines which is not accompanied by elevated levels of circulating IL-10, except for its insufficiently inhibitory elevation in UC patients.

show abstract

“…This specific cytokine pattern seems to have a prognostic effect, since high IL-6 or IL-10 serum concentrations are associated with negative prognoses in independent cancer types whereas TNFα and IL-6 are recognized as master regulators of tumor-associated inflammation and tumourigenesis (23)(24)(25). Since there is a strong connection between IL-6 level and hepatic production of CRP, CRP level could be used as indirect measure of the tumor activity (26,27).…”

Section: Discussionmentioning

confidence: 99%

Cancer-related inflammation as predicting tool for treatment outcome in locally advanced and metastatic non-small cell lung cancer

et al. 2016

View full text Add to dashboard Cite

Background: Lung cancer is the leading cause of cancer deaths and the non-small cell lung cancer (NSCLC) represents 80% of all cases. In most cases when diagnosed, it is in locally advanced or metastatic stage, when platinum based doublet chemotherapy is the established therapeutic option for majority of the patients.Predictive factors to filter the patients who will benefit the most from the chemotherapy are not clearly defined. Objective of this study was to explore predictive value of pre-treatment C-reactive protein (CRP), fibrinogen and their interaction, for the response to the frontline chemotherapy.Methods: In this retrospective cohort study 170 patients with locally advanced and metastatic NSCLC were included. Relationship between baseline level of CRP and fibrinogen and response to the frontline chemotherapy was assessed.Results: We found that pre-treatment CRP and fibrinogen values were statistically significantly correlated.Chemotherapy and CRP, fibrinogen, and their interaction were independently significantly associated with disease control rate at re-evaluation. There was statistically significant difference in median pre-treatment CRP level between the patients with disease control or progression at re-evaluation, 13.8 vs. 30.0 mg/L respectively, P=0.026. By Johnson-Neyman technique we found that in patients with initial fibrinogen value below 3.5 g/L, CRP level was significantly associated with disease control or progression of the disease.Above this fibrinogen value the association of CRP and disease control was lost. Conclusions:The findings from this study support the growing evidence of inflammation and cancer relationship, where elevated pre-treatment level of CRP has negative predictive significance on the NSCLC frontline chemotherapy response.

show abstract

Prognostic Significance of Circulating IL-10 and IL-6 Serum Levels in Colon Cancer Patients Undergoing Surgery

Cited by 203 publications

References 18 publications

The longitudinal relationship between circulating concentrations of C-reactive protein, interleukin-6 and interleukin-10 in patients undergoing resection for renal cancer

The longitudinal relationship between circulating concentrations of C-reactive protein, interleukin-6 and interleukin-10 in patients undergoing resection for renal cancer

Proinflammatory cytokines and IL-10 in inflammatory bowel disease and colorectal cancer patients

Cancer-related inflammation as predicting tool for treatment outcome in locally advanced and metastatic non-small cell lung cancer

Contact Info

Product

Resources

About