Prognostic significance of Cyclin A in epidermoid anal cancer

Abstract

Abstract. Ultimately aiming at a more individualized therapeutic approach in epidermoid anal cancer, this study explored the prognostic and predictive impact of a set of tumour markers. From a population-based cohort of 276 patients with epidermoid anal cancer, treated according to prospective protocols, 215 pre-treatment biopsies were investigated using immunohistochemistry. The expression of p53, p21, Cyclin A and CD31 was measured semiquantitatively. The expression rate was classified as high when immunostaining was seen in >5% of the tumour cells for p53 and p21, >20% in Cyclin A and, above median vessel count for CD31. Marker expression was correlated to survival and treatment response. A high Cyclin A expression correlated significantly with improved overall (77% vs 59%, p=0.005) and tumour-specific (81% vs 64 %, p=0.009) survival at 5 years. Also, the locoregional failure rate was significantly lower in patients with a high Cyclin A expression (12% vs 24%, p<0.05). In a multivariate Cox analysis Cyclin A was an independent prognostic factor. A low p21 expression correlated with a reduced rate of locoregional failure (14% vs 27%, p<0.05) but no impact on survival was found. For p53 and CD31 no significant correlations were obtained. Cyclin A may be an indicator of radiosensitivity and a valuable prognostic marker in epidermoid anal cancer.

Molecular Biomarkers Correlate with Disease-Free Survival in Patients with Anal Canal Carcinoma Treated with Chemoradiation

“…Methylation of several genes [59], human papilloma virus (HPV), p53, and AKT have been implicated in carcinogenesis of anal carcinoma [60]. Nilsson et al [61]. have reported the largest attempt to discover the prognostic factors for survival by studying the expression of p53, p21, cyclin A and CD 31 in 215 patients with anal carcinoma.…”

Prognostic Significance of Cell Cycle- and Invasion-Related Molecular Markers and Genomic Instability in Primary Carcinoma of the Vagina

“…17,21,43,44 However, in cervical and vulvar carcinoma, there are conflicting data on the prognostic value of these proliferation markers. In cervical adenocarcinoma, high levels of Ki67 staining was associated with more advanced stage at diagnosis and low grade, 45 whereas no prognostic value of Ki67 was demonstrated in a study on squamous cell carcinoma of the cervix.…”

Laminin-332-Integrin Interaction: A Target For Cancer Therapy?

“…For example, in colon carcinoma, urinary bladder carcinoma, colorectal carcinoma, SCC of the oral cavity, tongue, skin, kidney, prostate, lung, vagina, hand and neck, gastric carcinoma, alveolar carcinoma, breast cancer, splenic carcinoma, cervical adenocarcinoma, esophageal carcinoma, adenoid cystic carcinoma, ductal tumor of the pancreas, glioma, clear cell carcinoma of the ovary, and epidermoid anal cancer, cells or tissues adjacent to the tumor front express the laminin γ2 chain or its fragment [48][49][50][51][52][53][54][55][56][57][58][59][60][61][62][63][64][65]. The latter fragment is also known as the laminin γ2 short arm (SA) and includes an epidermal growth factor (EGF)-like domain.…”