Prognostic significance of cytochrome C release and tissue lactate dehydrogenase in patients with breast cancer

Mabrouk, Gamal M.; Zohny, Samir F.; Shehata, Hanan H.; Ali, Eyashin; Basyouni, M; El-Shinawi, Mohamed

doi:10.4314/ejbmb.v28i2.60792

Cited by 1 publication

(3 citation statements)

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Section: Discussioncontrasting

confidence: 72%

“…Despite several experimental research studies repeatedly demonstrating vitamin D antineoplastic activities on breast carcinoma, results from randomized trials and epidemiologic research studies are not definitive. 42 The findings of our study showed that the majority of women in Group-I (74.7%), Group-II (88.0%), and Group-III (76.0%) had vitamin D deficiency/insufficiency (Table 4 and Figure 7a). The findings of a study 35 demonstrated that vitamin D deficiency was more prevalent in G1 cases (85.7%) than in controls (55.8%), and the results were found statistically significant.…”

Section: Discussionmentioning

confidence: 52%

“…41 Results showed that cyt C levels were found to be elevated among females with malignant tumors compared to benign breast disease and healthy controls. Another puplication 42 included 90 women with breast carcinoma and 35 with benign proliferative breast disease and found that release from cyt C can be measured as a helpful prognostic indicator among women with breast carcinoma.…”

Section: Discussionmentioning

confidence: 99%

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Novel Noninvasive Serum Biomarkers for Prompt Diagnosis of Breast Carcinoma

Afzal,

Noreen,

Aslam

et al. 2023

ACS Omega

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Immune cell infiltration is associated with improved prognosis in the microenvironment of breast cancer. The incidence of breast cancer in Pakistan is 2.5 times higher than that in neighboring countries of Asia, accounting for 34.6% of female cancers. The objectives of this study were to compare and determine apoptotic mediators and biomarkers for breast carcinoma, such as serum granzyme B, cytochrome C, and vitamin D by ELIZA and calcium spectrophotometrically. Study groups were differentiated into malignant breast disease G-I, benign proliferative breast disease G-II, and healthy control group G-III. The immune-related prognostic markers and therapeutic targets were determined through the interaction of proteins by molecular docking and AutoDock Vina software. The level of granzyme B and cyt C was higher in Group-I, -II, and -III. Likewise, the mean vitamin D level was greater in Group-I than those in other groups. Through SwissDock, the proteins granzyme B and cyt C with vitamin D, single amino acid residue MET34 (H-bond 2.75 Å), and ILE81(H-bond 2.092 Å) were revealed to actively participate in interactions. This study reveals granzyme B and cyt C as biomarkers for malignant breast disease and benign proliferative breast disease, while hypovitaminosis D and hypocalcemia are complications or comorbidities of breast cancer.

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Section: Discussioncontrasting

confidence: 72%

Section: Discussionmentioning

confidence: 52%