2017
DOI: 10.18632/oncotarget.23424
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Prognostic significance of Cytokeratin 20-positive lymph node vascular endothelial growth factor A mRNA and chromodomain helicase DNA binding protein 4 in pN0 colorectal cancer patients

Abstract: BACKGROUNDCytokeratin 20-positive cells in lymph nodes from pN0 colorectal cancer (CRC) patients were detected previously by us. The aims of this study were to investigate which tumor metastasis-related genes were involved and their potential clinical significance.RESULTSFourteen of 84 (17%) genes were differentially expressed by at least 2-fold. Among them, 10 genes were up-regulated whereas 4 genes were down-regulated. Those differential expressed genes were validated in the second cohort of specimens. Follo… Show more

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“…Therefore, we here propose CHD4 as a novel prognostic factor in HPV-negative HNSCC patients. Besides HNSCC, previous studies suggested CHD4 as a prognostic marker in papillary thyroid cancer and low CHD4 expression had a beneficial effect on OAS and lower disease recurrence rates in patients afflicted with colorectal cancer 24 , 40 , 41 .…”
Section: Discussionmentioning
confidence: 99%
“…Therefore, we here propose CHD4 as a novel prognostic factor in HPV-negative HNSCC patients. Besides HNSCC, previous studies suggested CHD4 as a prognostic marker in papillary thyroid cancer and low CHD4 expression had a beneficial effect on OAS and lower disease recurrence rates in patients afflicted with colorectal cancer 24 , 40 , 41 .…”
Section: Discussionmentioning
confidence: 99%