Prognostic significance of cytoplasmic p27 in oral squamous cell carcinoma

Abstract

To the best of our knowledge, this is the first study to analyse cytoplasmic localization of p27 in OSCC and correlate with prognosis. Cytoplasmic localization is associated with poor prognosis in OSCC with lymph node metastasis allowing the consideration of cytoplasmic p27 in predicting prognosis and targeted therapeutic approaches.

Expression of Cell Cycle-related Proteins p16, p27 and Ki-67 Proliferating Marker in Laryngeal Squamous Cell Carcinomas and in Laryngeal Papillomas

“…It has been stated that the loss of p27 expression can be one of the mechanisms leading to tumor development and progression (14,31,32). In many reports, alterations in the expression of p27 have been noticed (8,(13)(14)(15). Some researches of HNSCC have revealed decreased nuclear expression, of p27 which is comparable to our observations (2,(13)(14)(15).…”

“…In many reports, alterations in the expression of p27 have been noticed (8,(13)(14)(15). Some researches of HNSCC have revealed decreased nuclear expression, of p27 which is comparable to our observations (2,(13)(14)(15). Furthermore, Fillies et al In this study we also noticed reduced nuclear expression of p27 in cancer cells, which was weaker in comparison to papilloma cells.…”

“…In this study, a correlation between nuclear expression of p27 in cancer cells and the survival rate was not observed. Although many studies have revealed that the nuclear expression of p27 is often associated with good prognosis, there are also reports in which such correlation has not been found (2,13,34,35). It has been suggested that a decreased p27 nuclear expression is associated with metastasis.…”

“…Interestingly, p27 can also inhibit the cell cycle directly without other cofactors, such as cyclin D or CDK4/6 (2). In normal cells, p27 expression is noticed in the nucleus, whilst in tumor cells, expression loss is observed (8,13). Although mutations of the p27 gene are rare in human cancer, a decreased expression of p27 in the nucleus of cancer cells has been associated with poor prognosis and reduced patient survival in many types of cancers, including HNSCC (8,13,14).…”

Cytoplasmic p27 is a novel prognostic biomarker and oncogenic protein for nasopharyngeal carcinoma

“…Cytoplasmic p27 is closely related to a poor prognosis in patients with tumour. Therefore, cytoplasmic p27 is considered an oncogenic protein [5][6][7][8][9]. Studies have shown that the serine/threonine protein kinase Akt protein is a key molecule that regulates the cytoplasmic p27 protein level; it can phosphorylate the threonine at position 157 of the p27 protein and restrict the cytoplasmic p27 protein to the nucleus [10].…”