Prognostic significance of del 17p, ZAP-70 and CD38 as independent indicators for B-CLL: correlation to response to treatment and disease outcome

El-Kinawy, Nihal S.; Sharaf, Howaida M.; El-Hamid, Manal Abd

doi:10.1016/j.ejmhg.2012.03.007

Cited by 10 publications

(3 citation statements)

References 23 publications

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“…In the present study, CD38 expression was positive in 33% of cases, however ZAP 70 was negative in all the patients. However, in another research 42.5% of the patients with CLL showed high levels of CD38 and 47.5% of the patients were ZAP-70 positive 23 . In a study conducted at India, CD38 & ZAP-70 positivity were reported in 36% and 25% of the patients respectively 24 .…”

Section: Discussionmentioning

confidence: 86%

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Correlation of Trisomy 12 With Clinical Features and Other Labortary Parameters in Patients With Chronic Lymphocytic Leukaemia

Ahmed

Hussain

Malik

et al. 2021

PAFMJ

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Objective: To determine the frequency of trisomy 12 in B-Cell chronic lymphocytic leukaemia (CLL), to correlate its association with clinico-pathologic features and to determine the role of this cytogenetic defect to the prognosis. Study Design: Cross sectional study. Place and Duration of Study: Haematology department, Armed Forces Institute of Pathology, Rawalpindi, from May 2017 to Aug 2018. Methodology: A total of 56 newly diagnosed patients of Chronic Lymphocytic Leukaemia were included in the study. Patients were diagnosed on the basis of National Cancer Institute Working Group guidelines. A detailed history and thorough clinical examination were performed and complete blood counts, biochemical profile, bone marrow examination, immunophenotyping on bone marrow/peripheral blood samples were done for the diagnosis of Chronic lymphocytic leukaemia. Interphase FISH studies were performed on blood/bone marrow aspiration for detection of Trisomy 12 were performed. Results: Out of 56 patients, trisomy was detected in 12 (10.7%) patients. Out of 7 patients with trisomy 12, five patients presented in late stages (Binet stage B and C), however this association of Trisomy 12 with Binet stage was also statistically insignificant (p=0.474). About six with trisomy 12 were positive for CD 38, however this association was also not statistically significant (p=0.124). Results revealed that patients having trisomy 12 underwent chemotherapy at diagnosis and during follow ups as compared to patients having other cytogenic abnormalities. Moreover, patient with trisomy 12 develop progression in disease during course of illness, however association was statistically insignificant (p>0.05)............

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Section: Discussionmentioning

confidence: 86%

“…In the present study, trisomy 12 was detected in 10.7% of the patients with CLL. In a study conducted by El-Kinawy et al, trisomy 12 was detected in 19.3% of the patients 23 . Bagir et al, detected trisomy 12 in 36 cases.…”

Section: Discussionmentioning

confidence: 92%

Correlation of Trisomy 12 With Clinical Features and Other Labortary Parameters in Patients With Chronic Lymphocytic Leukaemia

Ahmed

Hussain

Malik

et al. 2021

PAFMJ

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“…When a 30% cut-off for NGAL-R/CD38 co-expression was used, no significant difference was observed between (NGAL-R/CD38) low and (NGAL-R/CD38) high groups regarding sex, age, lymphocyte count, Binet stage, and IGHV mutational status. Enhanced CD38 expression is associated with CLL cells bearing trisomy 12 or del(17p) [ 20 , 21 , 22 ]. Our analysis confirmed and completed these data with significantly elevated NGAL-R/CD38 levels found in trisomy 12 cells compared to CLL cells without or with del(11q) and del(13q) ( Figure 1 c,d).…”

Section: Resultsmentioning

confidence: 99%

The Value of Neutrophil Gelatinase-Associated Lipocalin Receptor as a Novel Partner of CD38 in Chronic Lymphocytic Leukemia: From an Adverse Prognostic Factor to a Potential Pharmacological Target?

Bauvois,

Chapiro,

Quiney

et al. 2023

Biomedicines

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Chronic lymphocytic leukemia (CLL) is characterized by the accumulation of neoplastic B lymphocytes that escape death, and correlates with the expression of negative prognostic markers such as the CD38 antigen. Although certain new drugs approved by the US Food and Drug Administration improve the clinical outcome of CLL patients, drug resistance and disease relapse still occur. Like CD38, neutrophil gelatinase-associated lipocalin receptor (NGAL-R) is frequently overexpressed in CLL cells. Here, we evaluated the concomitant surface expression of NGAL-R and CD38 in leukemic blood cells from 52 CLL patients (37 untreated, 8 in clinical remission, and 7 relapsed). We provide evidence of a positive correlation between NGAL-R and CD38 levels both in the interpatient cohorts (p < 0.0001) and in individual patients, indicating a constitutive association of NGAL-R and CD38 at the cell level. Patients with progressing CLL showed a time-dependent increase in NGAL-R/CD38 levels. In treated CLL patients who achieved clinical remission, NGAL-R/CD38 levels were decreased, and were significantly lower than in the untreated and relapsed groups (p < 0.02). As NGAL-R and CD38 participate in CLL cell survival, envisioning their simultaneous inhibition with bispecific NGAL-R/CD38 antibodies capable of inducing leukemic cell death might provide therapeutic benefit for CLL patients.

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Prognostic models for newly-diagnosed chronic lymphocytic leukaemia in adults: a systematic review and meta-analysis

Kreuzberger

Damen

Trivella

et al. 2020

Cochrane Database of Systematic Reviews

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Prognostic significance of del 17p, ZAP-70 and CD38 as independent indicators for B-CLL: correlation to response to treatment and disease outcome

Cited by 10 publications

References 23 publications

Correlation of Trisomy 12 With Clinical Features and Other Labortary Parameters in Patients With Chronic Lymphocytic Leukaemia

Correlation of Trisomy 12 With Clinical Features and Other Labortary Parameters in Patients With Chronic Lymphocytic Leukaemia

The Value of Neutrophil Gelatinase-Associated Lipocalin Receptor as a Novel Partner of CD38 in Chronic Lymphocytic Leukemia: From an Adverse Prognostic Factor to a Potential Pharmacological Target?

Prognostic models for newly-diagnosed chronic lymphocytic leukaemia in adults: a systematic review and meta-analysis

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