Prognostic significance of epidermal growth factor receptor (EGFR) over expression in urothelial carcinoma of urinary bladder

Abstract

BackgroundEpidermal growth factor receptor (EGFR) has been shown to have abnormal expression in many human cancers and is considered as a marker of poor prognosis. Frequency of over expression in bladder cancer has not been studied in our population; therefore we aimed to evaluate the frequency and prognostic significance of EGFR immunohistochemical expression in locoregional population.MethodsWe performed EGFR immunohistochemistry on 126 cases of bladder cancer and association of EGFR expression with tumor grade, lamina propria invasion, deep muscle invasion and recurrence of disease was evaluated.ResultsHigh EGFR expression was noted in 26.2% (33 cases), 15.1% (19 cases) and 58.7% (74 cases) revealed low and no EGFR expression respectively. Significant association of EGFR expression was noted with tumor grade, lamina propria invasion, deep muscle invasion and recurrence status while no significant association was seen with age, gender and overall survival. Kaplan- Meier curves revealed significant association of EGFR expression with recurrence while no significant association was seen with overall survival.ConclusionSignificant association of EGFR overexpression with tumor grade, muscularis propria invasion and recurrence signifies its prognostic value; therefore EGFR can be used as a prognostic biomarker in Urothelial bladder carcinoma.

Targeted Delivery of 111In Into the Nuclei of EGFR Overexpressing Cells via Modular Nanotransporters With Anti-EGFR Affibody

“…Upregulation of this receptor may cause malignization as EGFR plays an important role in the regulation of cell division (Wang, 2017). Abnormal EGFR overexpression and signaling are associated with malignant tumors of the lung (Hirsch et al, 2009), pancreas (Lemoine et al, 1992;Ueda et al, 2004), brain (Hicks et al, 2006), bladder (Chow et al, 1997;Hashmi et al, 2018), breast , prostate (Peraldo-Neia et al, 2011), and other cancers (Mendelsohn and Baselga, 2000;Ciardiello and Tortora, 2008). EGFR, upon binding to its ligand, is not only capable to activate other signaling proteins, but is also transported inside endosomes from the surface of the cell membrane (Sorkin and Goh, 2009).…”

A panel of protein kinase high expression is associated with postoperative recurrence in cholangiocarcinoma

“…The EGFR family consists of four members: EGFR (HER1), HER2, HER3 and HER4. The overexpression of EGFR is more commonly found in the primary tumor stages III/IV than I/II [25], and has been previously identified as a predictor of tumor recurrence [26][27][28]. Moreover, knockdown of EGFR expression could reduce the colony formation, migration and proliferation of colorectal cancer (CRC) [27].…”

A comparative meta andin silicoanalysis of differentially expressed genes and proteins in canine and human bladder cancer

“…EGFR it is an important marker in human bladder cancer, being associated with overall survival, muscle invasiveness and tumor recurrence (Hashmi et al 2018). Thus, EGFR overexpression is studied as target for anti-EGFR therapies (Karyagina et al, 2020).…”