Prognostic significance of expression of vegf and cox‐2 in nasopharyngeal carcinoma and its association with expression of C‐erbB2 and EGFR

Kim, Taejung; Lee, Youn Soo; Kang, Jun‐Myung; Kim, Yeon‐Sil; Kang, Chang Suk

doi:10.1002/jso.21767

Cited by 29 publications

(28 citation statements)

References 45 publications

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“…Finally, we enrolled 15 eligible articles containing survival outcomes [11,[15][16][17][18]22,[24][25][26][27][28][29][30][31][32][33][34][35], among which two studies were written in Chinese [22,33], whereas the others were English articles. These eligible studies were published from 2002 to 2012.…”

Section: Eligible Studiesmentioning

confidence: 99%

“…Samples from North Asia (China, Korea, Japan, and Singapore) [15][16][17]22,24,25,[27][28][29][30][31][32][33][34] were yielded for HRs. The result suggested that EGFR was associated with NPC prognosis, and HR for OS was 2.05 [1.17, 3.60], (I2 = 92%, P = 0.…”

Section: Subgroup Analysismentioning

confidence: 99%

“…Studies applying 10% or 25% as cut-off values were tested separately. A 10% value [17,22,24,25,27,[29][30][31] Table 2). …”

Section: Subgroup Analysismentioning

confidence: 99%

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Epidermal growth factor receptor could play a prognostic role to predict the outcome of nasopharyngeal carcinoma: A meta-analysis

Huang

et al. 2014

CBM

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Section: Eligible Studiesmentioning

confidence: 99%

Section: Subgroup Analysismentioning

confidence: 99%

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Epidermal growth factor receptor could play a prognostic role to predict the outcome of nasopharyngeal carcinoma: A meta-analysis

Huang

et al. 2014

CBM

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“…For evaluation of DLL4 and VEGFR-2 expression, a semiquantitative scoring system was developed, which was based on both staining intensity (0, negative; 1, weak; 2, moderate; 3, strong) and percentage of positive cells (0, 0% cells; 1, B25% positive cells; 2, 26-50% positive cells; 3, [50% positive cells). 18,27,28 The 2 scores were added, with a maximum total score of 6. The high expression of a marker, DLL4 or VEGFR-2, was defined as a total score of more than 3.…”

Section: Immunostaining Evaluationmentioning

confidence: 99%

High Expression of Delta-Like Ligand 4 Predicts Poor Prognosis After Curative Resection for Pancreatic Cancer

et al. 2011

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“…Meanwhile, by activating various signal transduction pathways, LMP1 can regulate the expression levels of multiple metastasis related genes, such as E-cadherin, MMPs, c-Met, VEGF, EGFR and COX-2 [69].…”

Section: Mirna and Tumor Angiogenesis Invasion And Migrationmentioning

confidence: 99%

miRNA and nasopharyngeal carcinoma

2011

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MicroRNAs (miRNAs) constitute a family of small non-coding RNA molecules 22-25 nucleotides in length. miRNAs control the expression of target genes at the post-transcriptional level by inhibiting translation or by degrading target mRNA through binding to complementary sequences in the 3′-untranslated regions. Recent studies have demonstrated that miRNAs are intimately involved in processes leading to nasopharyngeal carcinoma, such as the Epstein-Barr virus-encoded latent membrane protein 1 activated signal transduction pathways, gene-regulatory networks, mitosis, tumor angiogenesis, invasion and migration. Exploring the relationship between miRNAs and the development of nasopharyngeal carcinoma, will further the understanding of this cancer and provide new avenues for diagnosis and treatment. . Nasopharyngeal carcinoma (NPC) is a head and neck epithelial malignancy that occurs frequently in Southern China [2]. It is characterized by high invasiveness and metastasis, and involves Epstein-Barr virus (EBV) infection and numerous genetic factors [3]. In this review, we focus on recent studies [4] that have described miRNA involvement in the carcinogenesis of NPC.1 miRNA biogenesis, regulatory mechanisms and biological functions 1.1 miRNA biogenesis and regulatory mechanisms miRNAs are small non-coding RNA molecules of about *Corresponding author (email: Lqz2010@hotmail.com; xiaoqing1213@sina.com) 22-25 nucleotides in length. miRNA genes are first transcribed by RNA polymerase II, to produce molecules hundreds of nucleotides in length, called pri-miRNAs. Then, Drosha, an RNA polymerase III, processes pri-miRNAs into stem-loop structures, 60-70 nucleotides in length, called pre-miRNAs. The transportation protein, Exportin-5, identifies and combines with the 3′-end of pre-miRNAs and, in a Ran-GTP-dependent manner, pre-miRNAs are exported from the nucleus into cytoplasm. With the involvement of another RNase III Dicer, the pre-miRNAs are further cleaved into double stranded RNAs (dsRNAs). A helicase then degrades one strand of the dsRNA, leaving the other strand a mature active miRNA to enter the nucleus and form the miRNA-associated RNA-induced silencing complex (miRISC) [5][6][7]. Within this complex, miRNAs can play essential roles in biological functions.miRNAs control the expression of target genes at the post-transcriptional level by inhibiting protein translation or by degrading cognate target mRNAs through binding to their 3′-untranslated regions (UTRs) with varying degrees of sequence complementarity. miRNAs are also involved in

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Prognostic significance of expression of vegf and cox‐2 in nasopharyngeal carcinoma and its association with expression of C‐erbB2 and EGFR

Abstract: Absence of VEGF is a useful indicator of poor prognosis in addition to Cox-2 expression, high stage, and high mitosis.

Cited by 29 publications

References 45 publications

Epidermal growth factor receptor could play a prognostic role to predict the outcome of nasopharyngeal carcinoma: A meta-analysis

Epidermal growth factor receptor could play a prognostic role to predict the outcome of nasopharyngeal carcinoma: A meta-analysis

High Expression of Delta-Like Ligand 4 Predicts Poor Prognosis After Curative Resection for Pancreatic Cancer

miRNA and nasopharyngeal carcinoma

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