Prognostic significance of functional capacity and exercise behavior in patients with metastatic non-small cell lung cancer

Jones, Lee W.; Hornsby, Whitney E.; Goetzinger, Amy M.; Forbes, Lindsay M.; Sherrard, Emily L.; Quist, Morten; Lane, Amy R.; West, Mike; Eves, Neil D.; Gradison, Margaret; Coan, April; Herndon, James E.; Abernethy, Amy P.

doi:10.1016/j.lungcan.2011.10.009

Cited by 185 publications

(160 citation statements)

References 35 publications

Supporting

Mentioning

146

Contrasting

Unclassified

Order By: Relevance

“…[12][13][14] These techniques have not been studied in patients planning to undergo HCT. Studies have demonstrated the feasibility of VO 2peak measurement in survivors of allogeneic HCT, [15][16][17] and the potential benefit of exercise intervention in ameliorating functional decline.…”

Section: Introductionmentioning

confidence: 99%

Cardiopulmonary fitness in patients undergoing hematopoietic SCT: a pilot study

Wood

Deal

Reeve

et al. 2013

Bone Marrow Transplant

View full text Add to dashboard Cite

Hematopoietic cell transplantation (HCT) is a life-saving treatment for patients with high-risk hematological malignancies. Prognostic measures to determine fitness for HCT are needed to inform decision-making and interventions. VO 2peak is obtained by measuring gas exchange during cycle ergometry and has not been studied as a prognostic factor in HCT. Thirty-two autologous and allogeneic HCT patients underwent VO 2peak and 6 Minute Walk (6MW) testing before HCT, and provided weekly symptom and health-related quality of life (HRQOL) assessments before HCT and concluding at Day 100. Twenty-nine patients completed pre-HCT testing. Pre-HCT VO 2peak was positively correlated with pre-HCT 6MW (r ¼ 0.65, Po0.001) and negatively correlated with number of chemotherapy regimens and months of chemotherapy. Patients with lower VO 2peak reported higher symptom burden and inferior HRQOL at baseline and during early post-HCT period. Patients with pre-HCT VO 2peak o16 mL/kg/min had higher risk of mortality post HCT (entire cohort: hazard ratio (HR) 9.1 (1.75-47.0), P ¼ 0.01; allogeneic HCT patients only: HR 6.70 (1.29-34.75), P ¼ 0.02) and more hospitalized days before Day 100 (entire cohort: median 33 vs 19, P ¼ 0.003; allogeneic HCT patients only: median 33 vs 21, P ¼ 0.004). VO 2peak pre-HCT is feasible and might predict symptom severity, HRQOL and mortality. Additional studies are warranted. Keywords: cardiopulmonary fitness; symptoms; health-related quality of life; hematopoietic SCT INTRODUCTIONFor patients with life-threatening hematological diseases, hematopoietic cell transplantation (HCT) offers the possibility of extended survival relative to standard conventional treatments. 1 The benefits of HCT are counterbalanced by the risk of treatmentrelated toxicity. Prognostic measures are needed to inform clinician and patient decision-making and to limit treatmentrelated risk. Direct cardiopulmonary fitness assessments such as VO 2peak are now available but have not yet been studied.Myeloablative allogeneic HCT has been associated with a 30-40% risk of treatment-related mortality (TRM). 2 Reduced intensity conditioning HCT is offered to older individuals and patients with comorbid illness, but this technique is still associated with a 20-30% risk of TRM. 3 Autologous HCT in older patients has been associated with a TRM risk exceeding 10%. 4 Subsets of patients after all types of transplants experience late health-related quality of life (HRQOL) deficits and functional impairment; 5 this effect is variable with other subgroups experiencing preserved patient-reported outcomes (PROs), relative to normative values. 6 Investigators and clinicians have attempted to determine who is 'fit' for transplant to inform pre-HCT counseling, selection of suitable HCT candidates and identification of vulnerable HCT recipients at risk for treatment-related complications. 7 Age remains the most commonly used surrogate variable for HCT

show abstract

Section: Introductionmentioning

confidence: 99%

Cardiopulmonary fitness in patients undergoing hematopoietic SCT: a pilot study

Wood

Deal

Reeve

et al. 2013

Bone Marrow Transplant

View full text Add to dashboard Cite

show abstract

“…Cancer patients who are more physically able are less likely to have treatment resistant-disease 46 and to experience increased life expectancy [46][47][48] .…”

mentioning

confidence: 99%

Exercise and Nutrition Interventions in Advanced Lung Cancer: A Systematic Review

et al. 2013

View full text Add to dashboard Cite

show abstract

“…Recent studies also show that physical performance is an independent predictor of survival in NSCLC patients [21][22][23], currently the same goes for depression and anxiety which usually accompanies the disease [24].…”

Section: Introductionmentioning

confidence: 89%

“…The same author has subsequently shown that the reduction in exercise capacity is a strong predictor of mortality, which is regarded as the VO 2 peak [33], or the MET'S products or meters walked to the walk test [34].…”

Section: Functional Assessmentmentioning

confidence: 99%

Pulmonary Rehabilitation in lung cancer

Pasqua

Geraneo

Nardi

et al. 2015

Monaldi Arch Chest Dis

View full text Add to dashboard Cite

Non-small-cell lung cancer (NSCLC) represents a very severe disease, being its incidence increasingly reported and, nowadays, successfully treatable only when surgery is deemed to be feasible. Furthermore, the disease and the clinical effects related to the complementary therapies (radio and/or chemotherapy) may strongly affect, frequently with dramatic clinical side effects, the patient’s ability to endure physical exercise. In such context, the PR(PR), which has already been proved to be useful and effective in other diseases such as COPD, could play a pivotal role. The aim of this review article is, therefore, to analyze the pertinent data recently reported in English literature in order to highlight the role of rehabilitation as complementary therapy in the management of patients with NSCLC. The evidence currently available suggests that, when surgery is indicated, PR is a safe and feasible option, both during pre-operative and post-operative timing.The safety and feasibility of rehabilitation are proven even in inoperable patients, although to date, little evidence has been reported on its role in the overall management of such complex diseases.

show abstract

Prognostic significance of functional capacity and exercise behavior in patients with metastatic non-small cell lung cancer

Cited by 185 publications

References 35 publications

Cardiopulmonary fitness in patients undergoing hematopoietic SCT: a pilot study

Cardiopulmonary fitness in patients undergoing hematopoietic SCT: a pilot study

Exercise and Nutrition Interventions in Advanced Lung Cancer: A Systematic Review

Pulmonary Rehabilitation in lung cancer

Contact Info

Product

Resources

About