Prognostic significance of gamma‐glutamyl transpeptidase to albumin ratio in patients with intrahepatic cholangiocarcinoma after hepatectomy

Abstract

Inflammation has been reported to play an important role in tumour progression and prognosis. In this study, we evaluated the prognostic significance of γ‐glutamyl transpeptidase (GGT) to albumin ratio (GAR) in patients with intrahepatic cholangiocarcinoma (ICC) after hepatectomy. We retrospectively analysed 650 ICC patients underwent hepatectomy at three Chinese medical centres between January 2009 and September 2017. Patients were classified into derivation cohort ( n = 509) and validation cohort ( n = 141). Receiver operating characteristic (ROC) curve was used to determine the optimal cut‐off value for GAR. Survival curve and cox regression analysis were applied to assess the prognostic power of GAR. The prognostic accuracy of GAR was compared with other variables by ROC curve. The optimal cut‐off value for GAR was 1.3655. Preoperative high GAR was closely related to tumour number, lymph node invasion and GGT. The survival curve of derivation and validation cohorts showed that patients in the high GAR group had significantly shorter overall survival (OS) and disease‐free survival (DFS) than patients in the low GAR group. Multivariate analysis in the derivation cohort confirmed that GAR was an independent prognostic factor for survival outcomes. Moreover, the ROC curve revealed that GAR had better predictive accuracy than other variables. High GAR predicted poor OS and DFS in ICC patients after hepatectomy. GAR may be a novel, simple and effective prognostic marker for ICC patients.

Significance of Fib4 index as an indicator of alcoholic hepatotoxicity in health examinations among Japanese male workers: a cross-sectional and retrospectively longitudinal study

“…By light microscopy, alcoholic liver samples had a marked GGT activity in the bile canaliculi and a diffuse activity in the cytoplasm [ 32 ]. Recently, the GGT/albumin ratio included gamma‐glutamyl transpeptidase, and albumin is a novel inflammatory marker [ 33 ]. These findings on GGT are mainly involved in glutathione metabolism and cellular protection against oxidative damage [ 13 ].…”

The Augural Interplay of Myosteatosis and Gamma-Glutamyltransferase in Patients Undergoing Comprehensive Surgical Intervention for Cholangiocarcinoma

“…Esteemed as a mercaptan-rich enzyme, GGT is most profuse within the renal system, trailed by the pancreas, pulmonary organs, and hepatic structures, where it partakes in the conveyance of glutamine molecules throughout the organism [29,30]. The current corpus of scienti c literature posits that GGT plays a cardinal role in contributing to unfavorable outcomes in oncology patients by stimulating the generation of reactive oxygen species (ROS) within the neoplastic microcosm, thereby spurring the proliferation, expansion, and in ltration of the malignant growth [31]. A surge in GGT concentrations may be discerned in a diversity of hepatobiliary maladies, cementing its reputation as a sensitive and invaluable clinical barometer for these disorders [32][33][34].…”