Prognostic significance of grading (MIB-1 system) in patients with myxoid liposarcoma

Tateishi, Ukihide; Hasegawa, Tadashi; Beppu, Yasuo; Kawai, Akimitsu; Moriyama, Noriyuki

doi:10.1136/jcp.56.8.579

Cited by 16 publications

(12 citation statements)

References 14 publications

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“…Microscopically, it shows lipoblasts in different degree of maturation, delicate thin walled arborizing and curving blood vessels present in a myxoid background. Several prognostic factors have been reported to significantly affect the survival including: percent of round cell component, necrosis, mitosis, MIB-1 labeling index, and tumor grade [8]. Of those factors, the presence of >5% round cell component portends a worse prognosis [9].…”

Section: Discussionmentioning

confidence: 99%

Paratesticular Myxoid Liposarcoma: A Case Report of Unusual Age of Presentation

Al‐Obaidy¹,

Abdulfatah²,

Lonardo³

et al. 2017

J Mol Biomark Diagn

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Paratesticular liposarcomas are relatively common sarcomas in the paratesticular region, however, the myxoid variant; myxoid liposarcoma (MLS) is considered very rare. MLS peaks around the fourth-fifth decade. Herein, we describe a case of paratesticular MLS occurring in a 19-year-old African American male who underwent resection of a slowly growing testicular mass over a period of one and a half years that was considered initially by his primary care physician to be a benign lesion. The resection margins were positive for tumor and the patient developed local recurrence one year after the initial resection. An extremely unusual age of presentation along with the importance of margin status in tumor recurrence is highlighted.

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Section: Discussionmentioning

confidence: 99%

Paratesticular Myxoid Liposarcoma: A Case Report of Unusual Age of Presentation

Al‐Obaidy¹,

Abdulfatah²,

Lonardo³

et al. 2017

J Mol Biomark Diagn

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“…1,2,5,7 Pada sarkoma jaringan lunak, secara umum sistem grading selain berdasarkan diferensiasi tumor/tipe histologi, juga berdasarkan nekrosis dan skor atau nilai imunoekspresi Ki-67. [9][10][11] Pada penelitian ini dipergunakan pemeriksaan khusus imunohistokima antibodi monoklonal Ki-67. Dengan menggunakan antibodi monoklonal Ki-67 proliferasi sel akan dapat terdeteksi oleh karena antibodi ini hanya akan terekspresi pada sel yang proliferatif.…”

Section: Pendahuluanunclassified

“…3,[11][12][13] Antibodi monoklonal Ki-67 akan bereaksi positif dengan inti sel-sel tumor dan keadaan ini disebut imunoreaktif. Derajat proliferasi suatu tumor berhubungan erat dengan perilaku biologik tumor tersebut, semakin cepat dan tinggi derajat proliferasi tumor, maka semakin agresif tumor tersebut sehingga prognosisnya semakin buruk [9][10][11][12][13][14] Tujuan penelitian ini untuk mengetahui apakah terdapat hubungan ekspresi antibodi monoklonal Ki-67 dengan grading histopatologi liposarkoma sehingga dapat merupakan salah satu indikator prognosis. …”

Section: Pendahuluanunclassified

“…[1][2][3]9,13,14 Seiring dengan penentuan grading sarkoma ini, beberapa peneliti menyatakan Ki-67 dapat dipakai secara luas pada patologi sebagai marker proliferasi dari banyak organ termasuk sarkoma jaringan lunak dan merupakan kriteria keganasan atau grading yang tentunya berhubungan dengan progresivitas suatu sarkoma, sehingga ekspresi Ki-67 ini berhubungan dengan prognosis sarkoma tersebut. 9,10,12,13 Didapatkan korelasi ekspresi Ki-67 sebagai marker proliferasi dengan grading tumor serta metastasis jauh dari sarkoma jaringan lunak termasuk liposarkoma.…”

Section: Pembahasanunclassified

“…9 ekspresi Ki-67 tersebut selain berkorelasi dengan grading sarkoma jaringan lunak, juga merupakan salah satu faktor prognostik penderita myxoid liposarcoma. 9 Pada penelitian ini didapatkan ekspresi dan intensitas Ki-67 yang kuat hanya pada high-grade Begitu pula untuk intensitas warna Ki-67, bahwa makin tinggi grading histopatologi liposarkoma, maka semakin kuat pula intensitas warna pulasan Ki-67. Dari beberapa hasil penelitian dilaporkan bahwa persentase ekspresi Ki-67 pada berbagai tumor bervariasi, sehingga hal ini akan menunjukkan gambaran ekspresi dengan range yang cukup luas antara tumor jinak dan tumor ganas.…”

Section: Pembahasanunclassified

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Hubungan Ekspresi Ki-67 dengan Grading Histopatologi Liposarkoma

Afiati¹,

Hernowo²

2013

mkb

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AbstrakLiposarkoma merupakan salah satu tumor ganas jaringan lunak dan terbanyak ditemukan pada usia dewasa antara dekade 5 dan 7 serta jarang terjadi pada usia anak. Liposarkoma sering terjadi pada ekstremitas bawah (fosa poplitea dan paha bagian tengah), retroperitoneal, perirenal, mesenteric region, dan area bahu. Penelitian ini bersifat retrospektif dari 30 kasus liposarkoma yang diambil dari data Departemen Patologi Anatomi Rumah Sakit Dr. Hasan Sadikin Bandung yang terdiri atas 20 kasus low-grade liposarcoma dan 10 kasus high-grade liposarcoma. Penelitian dilakukan periode Februari-Mei 2011. Dilakukan pemeriksaan khusus imunohistokimia dengan menggunakan antibodi monoklonal Ki-67 yang berfungsi sebagai marker proliferasi sel, dengan tujuan melihat ekspresi Ki-67 dan apakah terdapat hubungan antara ekspresi Ki-67 dan grading histopatologi liposarkoma. Ekspresi dan intensitas warna Ki-67 pada sel tumor dibagi menjadi sangat rendah (<20% positif), rendah (20-50% positif), sedang (50-80% positif) dan tinggi (>80% positif), sedangkan untuk intensitas warna Ki-67 dibagi menjadi lemah, sedang, dan kuat. Terdapat perbedaan yang signifikan antara ekspresi dan intensitas Ki-67 pada low-grade liposarcoma dan high-grade liposarcoma (p<0,0001). Simpulan, ekspresi Ki-67 yang tinggi dengan intensitas yang kuat hanya didapatkan pada high-grade liposarcoma yang juga berhubungan dengan progresivitas tumor. [MKB. 2013;45(3) Correlation of Ki-67 Expression with Histopathological Grading of Liposarcoma AbstractLiposarcoma, a malignant tumor of mesenchymal origin, was one of the most common sarcomas of adults and occurs primarily in the fifth through seventh decades of life. The occurrence in children was rare. Liposarcoma were occur most frequently in the lower extremities (popliteal fossa and medial thigh), retroperitoneal, perirenal, mesenteric region and shoulder area. Retrospective study was conducted by reviewing the data from Pathology Anatomy Department Dr. Hasan Sadikin Hospital Bandung. There were 30 cases of liposarcoma, whereas lowgrade of liposarcoma 20 cases and high-grade of liposarcoma 10 cases. Research was done during February-May 2011. Immunohistochemical staining examination used monoclonal antibody Ki-67 as marker cell proliferation with the aim for looking Ki-67 expression and related with histopatholgy grade of liposarcoma. The tumor cells which showed Ki-67 expression were divided into very low (<20% positive), low (20-50% positive), moderate (50-80% positive) and high (>80% positive), whereas the intensity of Ki-67 staining was into weak, moderate and strong. There were significant differences between the Ki-67 expression and intensity level according to the histopathological types of liposarcoma (p<0.0001). In conclusions, Ki-67 expression increases with strong intensity of Ki-67 only in high-grade liposarcoma, so relates with progressivity of tumor. [MKB. 2013;45(3):187-91]

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Cancer‐testis antigens PRAME and NY‐ESO‐1 correlate with tumour grade and poor prognosis in myxoid liposarcoma

Iura

Kohashi

Hotokebuchi

et al. 2015

The Journal of Pathology CR

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Myxoid liposarcoma is the second most common liposarcoma. Although myxoid liposarcoma is relatively chemosensitive and thus a good candidate for chemotherapy, cases with relapsed or metastatic disease still have poor outcome. Here, we performed a gene microarray analysis to compare the gene expression profiles in six clinical myxoid liposarcoma samples and three normal adipose tissue samples, and to identify molecular biomarkers that would be useful as diagnostic markers or treatment targets in myxoid liposarcoma. This showed that the cancer‐testis antigen PRAME was up‐regulated in myxoid liposarcoma. We then performed immunohistochemical, western blotting and real‐time polymerase chain reaction analyses to quantify the expression of PRAME and another cancer‐testis antigen, NY‐ESO‐1, in clinical samples of myxoid liposarcoma (n = 93), dedifferentiated (n = 46), well‐differentiated (n = 32) and pleomorphic liposarcomas (n = 14). Immunohistochemically, positivity for PRAME and NY‐ESO‐1 was observed in 84/93 (90%) and 83/93 (89%) of the myxoid liposarcomas, and in 20/46 (43%) and 3/46 (7%) of the dedifferentiated, 3/32 (9%) and 1/32 (3%) of the well‐differentiated and 7/14 (50%) and 3/21 (21%) of the pleomorphic liposarcomas, respectively. High immunohistochemical expression of PRAME and/or NY‐ESO‐1 was significantly correlated with tumour diameter, the existence of tumour necrosis, a round‐cell component of >5%, higher histological grade and advanced clinical stage. High PRAME and NY‐ESO‐1 expression correlated significantly with poor prognosis in a univariate analysis. The myxoid liposarcomas showed significantly higher protein and mRNA expression levels of PRAME and NY‐ESO‐1 (CTAG1B) than the other liposarcomas. In conclusion, PRAME and NY‐ESO‐1 (CTAG1B) were expressed in the vast majority of myxoid liposarcomas, and their high‐level expression correlated with tumour grade and poor prognosis. Our results support the potential use of PRAME and NY‐ESO‐1 as ancillary parameters for differential diagnosis and as prognostic biomarkers, and indicate that the development of immunotherapy against these cancer‐testis antigens in myxoid liposarcoma would be warranted.

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Prognostic significance of grading (MIB-1 system) in patients with myxoid liposarcoma

Cited by 16 publications

References 14 publications

Paratesticular Myxoid Liposarcoma: A Case Report of Unusual Age of Presentation

Paratesticular Myxoid Liposarcoma: A Case Report of Unusual Age of Presentation

Hubungan Ekspresi Ki-67 dengan Grading Histopatologi Liposarkoma

Cancer‐testis antigens PRAME and NY‐ESO‐1 correlate with tumour grade and poor prognosis in myxoid liposarcoma

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