2020
DOI: 10.3748/wjg.v26.i18.2221
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Prognostic significance of hepatic encephalopathy in patients with cirrhosis treated with current standards of care

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Cited by 33 publications
(29 citation statements)
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“…This study proves that ascites, which is a manifestation of portal hypertension, is associated with the incidence of HE. These results are consistent with studies by Bohra et al that HE occurs in patients with advanced cirrhosis, decompensation, and portal hypertension, and the most common precipitating factors are infection, gastrointestinal bleeding, constipation, non-adherence to medication, and electrolyte imbalance (16). A study by Tapper et al in 2019 found that two factors which most strongly associated with HE were alcohol-related liver cirrhosis and the presence of portal hypertension (17).…”
Section: Discussionsupporting
confidence: 90%
“…This study proves that ascites, which is a manifestation of portal hypertension, is associated with the incidence of HE. These results are consistent with studies by Bohra et al that HE occurs in patients with advanced cirrhosis, decompensation, and portal hypertension, and the most common precipitating factors are infection, gastrointestinal bleeding, constipation, non-adherence to medication, and electrolyte imbalance (16). A study by Tapper et al in 2019 found that two factors which most strongly associated with HE were alcohol-related liver cirrhosis and the presence of portal hypertension (17).…”
Section: Discussionsupporting
confidence: 90%
“…In the current study by Bohra et al [ 1 ], the authors concluded that the use of Rifaximin failed to have prognostic impact on the outcomes of patients with decompensated liver disease. The probability of survival at 12 mo was 44% for the entire cohort, seemingly no different to the survival figures from studies in the ‘pre-rifaximin era’[ 5 ].…”
Section: To the Editormentioning
confidence: 75%
“…We read with interest this retrospective study by Bohra et al [ 1 ]. We thank the authors for sharing their real-life data in which they looked into the natural history of patients presenting to the gastroenterology inpatient service with refractory/recurrent hepatic encephalopathy (HE) and use of Rifaximin.…”
Section: To the Editormentioning
confidence: 99%
“…Covert HE is the preclinical stage of overt HE and refers to cognitive dysfunction (such as difficulty in decision-making and psychomotor slowing) without disorientation [5] while overt HE (OHE) is the presence of symptoms such as confusion, dysarthria, stupor, and coma. The development of OHE is a poor prognostic sign in the setting of chronic liver disease with the probability of survival of 44% at 1 year [6]. In the setting of acute liver failure, the development of HE is a harbinger of progressive hepatic failure.…”
Section: Introductionmentioning
confidence: 99%