Prognostic significance of histologically detected lymph node micrometastases of sizes between 0.2 and 2 mm in colorectal cancer

Märkl, Bruno; Herbst, Candice-Lee; Cacchi, Claudio; Schaller, Tina; Krammer, Ines; Schenkirsch, Gerhard; Probst, Andreas; Spatz, Hanno

doi:10.1007/s00384-012-1636-y

Cited by 13 publications

(5 citation statements)

References 24 publications

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“…Some studies suggest that micrometastases and ITC found in the SN are a sign of another, presumably systemic disease, which may not justify an aggressive treatment approach [17][18][19][20][21] . Micrometastases is considered an important factor for predicting the prognosis and selecting a surgical strategy 22,23 .…”

Section: Discussionmentioning

confidence: 99%

Predictive factors for dissection-free sentinel node micrometastases in early oral squamous cell carcinoma

Matsuzuka

Tsukahara

Yoshimoto

et al. 2023

Sci Rep

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This sentinel node (SN) biopsy trial aimed to assess its effectiveness in identifying predictive factors of micrometastases and to determine whether elective neck dissection is necessary in oral squamous cell carcinoma. This retrospective study included 55 patients from three previous trials, with positive SNs. The relationship between the sizes of the metastatic focus and metastasis in non-sentinel node (NSN) was investigated. Four of the 55 largest metastatic focus were isolated tumor cells, and the remaining 51 were ranged from 0.2 to 15 mm, with a median of 2.6 mm. The difference of prevalence between 46 negative- and 9 positive-NSN was statistically significant with regard to age, long diameter of primary site and number of cases with regional recurrence. In comparing the size of largest metastatic focus dividing the number of positive SN, with metastaic focus range of < 3.0 mm in one-positive SN group, there were 18 (33%) negative-NSN and no positive-NSN. Regarding prognosis, 3-year overall survival rate of this group (n = 18) and other (n = 37) were 94% and 73% (p = 0.04), and 3-year recurrence free survival rate of this group and other were 94% and 51% (p = 0.03), respectively. Absolutely a further prospective clinical trial would be needed, micrometastases may be defined as solitary SN metastasis with < 3.0 mm of metastatic focus, and approximately 33% of neck dissections could be avoided using these criteria.

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Section: Discussionmentioning

confidence: 99%

Predictive factors for dissection-free sentinel node micrometastases in early oral squamous cell carcinoma

Matsuzuka

Tsukahara

Yoshimoto

et al. 2023

Sci Rep

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“…International Union Against Cancer (UICC) defines the metastasis <0.2 mm as isolated tumor cells or clusters, and the lesion >0.2 and <2.0 mm as micrometastasis. Many experts consider micrometastasis as an important factor for prognosis and selecting surgery ( 19 , 20 ). This study demonstrated that IHC could detect micrometastasis that was not detected by H&E staining, this indicated that IHC was more sensitive than H&E staining and could reduce missed diagnosis of lymph node metastasis, thus could be complementary to routine H&E staining.…”

Section: Discussionmentioning

confidence: 99%

Clinical significance of cytokeratin in the cervical lymph nodes of patients with mandibular gingival squamous cell carcinoma

Duan

Xu²,

Zhang

et al. 2018

Oncol Lett

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The present study aims to analyze the expression of broad spectrum cytokeratin in the cervical lymph nodes of patients with mandibular gingival squamous cell carcinoma and explore the metastasis of mandibular gingival squamous cell carcinoma in cervical lymph nodes. This study included 42 patients with mandibular gingival squamous cell carcinoma, which was staged according to the clinical staging criteria by International Union Against Cancer 2002 (UICC) and the Level staging method of cervical lymph node by American Academy of Otolaryngology-Head and Neck Surgery 1991. Monoclonal mouse anti-human cytokeratin (AE1/AE3) antibody was used in immunohistochemical examination and hematoxylin and eosin (H&E) staining. All positive sections by H&E staining were also positive by immunohistochemistry (IHC). The positive rate of routine H&E staining and serial-section H&E staining was 8.03 and 9.57%, respectively, the positive rate of IHC was 12.82%. The positive rate of IHC was significantly different with that of routine H&E staining (χ2=7.17, P<0.01), yet not significantly different with that of serial-section H&E staining (χ2=3.10, P>0.05). Lymph node metastasis was mainly in Level I, II and III, both serial-section H&E staining and IHC showed lymph node metastasis in Level IV for advanced patients. IHC showed 19 lymph node micrometastasis in 12 patients, while neither serial-section nor routine H&E staining showed micrometastasis. Lymph node dissection of hyoid bone (mainly in Level I, II and III) could be used for early patients, and the dissection could be expanded to Level IV for advanced patients.

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“…Among the cases treated with neoCRT, more micrometastases were present in cases with strong CRT-induced tumour regression. While the prognostic role of micrometastases after neoadjuvant treatment seems not be comparable to macrometastases,9 the role in primarily resected cases is less clear and several studies show similar survival rates for macrometastases and micrometastases 17 18. There is evidence that more comprehensive LN investigations such as ultrastaging by multiple sections per paraffin block and IHC do increase detection of patients who have a higher risk for recurrent disease 19.…”

Section: Discussionmentioning

confidence: 99%

Comprehensive lymph node morphometry in rectal cancer using acetone compression

et al. 2015

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Prognostic significance of histologically detected lymph node micrometastases of sizes between 0.2 and 2 mm in colorectal cancer

Abstract: Our data show that micro- and macrometastatic colorectal cancers show very similar survival rates. Therefore, efforts to improve the detection of lymph node micrometastases seem to be justified.

Cited by 13 publications

References 24 publications

Predictive factors for dissection-free sentinel node micrometastases in early oral squamous cell carcinoma

Predictive factors for dissection-free sentinel node micrometastases in early oral squamous cell carcinoma

Clinical significance of cytokeratin in the cervical lymph nodes of patients with mandibular gingival squamous cell carcinoma

Comprehensive lymph node morphometry in rectal cancer using acetone compression

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