Prognostic significance of human epididymis protein 4 in epithelial ovarian cancer

Human epididymis protein 4 (HE4) in laboratory medicine and an algorithm in renal disorders

“…Finally, serum HE4 level may be a suitable predictor for the survival of patients. Patients with elevated HE4 levels had a shorter surveillance than that of patients with normal HE4 (20.1 vs. 24.2 months) in advanced EOC [21]. Taken together, as it was concluded by a recent systematic literature search, HE4 is a promising and reliable EOC marker [27].…”

“…Besides serous ovarian tumors, pulmonary, gastrointestinal, endometrial, and breast carcinomas also displayed considerable immunoreactivity for HE4 [11,20]. However, the highest expression was consistently found in epithelial ovarian cancer (EOC) [11,20,21]. Finally, the immunological quantitation of serum HE4 levels was established, and it was rapidly introduced as a novel laboratory marker in EOC [7].…”

Human epididymis protein 4 (HE4) and ovarian cancer prognosis

“…The role of HE4 for early detection of OC has been extensively assessed [8][9][10][11]. However, only few studies have evaluated the role of pre-treatment HE4 as a prognostic factor of OC [12][13][14]. These studies suggest that preoperative serum levels of HE4 might have a prognostic significance in OC [12][13][14].…”

New Tumor Biomarkers in Ovarian Cancer and Its Prognostic and Clinical Relevance

“…However, subsequent validation in clinical setting did not confirm any benefit compared to use of CA125 alone [52,53]. As to prognostic relevance, Peak et al have shown that an elevated serum HE4 level was associated with reduced progression-free survival [54].…”

“…Secreted glycoprotein Unclear due to partly contradictory results [50,52,65] No conclusive data Prognostic relevance -yes (data from small studies) [54] Mesothelin Surface antigen of mesothelial cells…”