Prognostic significance of human papillomavirus in oropharyngeal squamous cell carcinomas

Sedaghat, Ahmad R.; Zhang, Zhe; Begum, Shahnaz; Palermo, Robert A.; Best, Simon R.; Ulmer, Karen; Levine, Marshall; Zinreich, Eva S.; Messing, Barbara; Gold, Dorothy; Wu, Annie A.; Niparko, Kevin J.; Kowalski, Jeanne; Hirata, Richard M.; Saunders, John R.; Westra, William H.; Pai, Sara I.

doi:10.1002/lary.20533

Cited by 132 publications

(107 citation statements)

References 25 publications

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“…Therefore, it can be speculated that different epigenetic and genetic pathways may affect cancer evolution and prognosis. Although we are only just starting to understand the impact of molecular findings in patient prognosis, previous reports have already suggested that HPV infection has an impact on the prognosis of HNSCC (68,69).…”

Section: Discussionmentioning

confidence: 99%

Effect of age on the association between p16CDKN2A methylation and DNMT3B polymorphism in head and neck carcinoma and patient survival

Farias

Fraga²,

Oliveira³

et al. 2010

Int J Oncol

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Abstract.De novo DNA methylation is a relevant epigenetic mechanism, which represses gene transcription and commonly inactivates tumor suppressor genes in carcinogenesis. A single nucleotide polymorphism of DNMT3B, C46359T (-149C→T) was reported to modulate individual's susceptibility to cancer. We investigated the role of this polymorphic variant regarding the methylation status of the p16CDKN2A gene in young and older patients with head and neck squamous cell carcinoma (HNCC) matched by the TNM staging system, together with its impact on patients survival. The results showed that the presence of the allele T of the polymorphism DNMT3B (-149C→T) was associated with advanced TNM staging and smoking habit, but no association was found between this polymorphisms and DNMT3B immunostaining. While p16CDKN2A methylation was significantly associated with smoking habit in older patients, this parameter was associated with family history of cancer in young patients. Moreover, in older patients the absence of p16CDKN2A promoter methylation had a negative impact on survival. In conclusion, nucleotide polymorphism of DNMT3B is not associated with methylation of p16CDKN2A gene in HNSCC. The association of p16CDKN2A gene methylation with smoking, family history of cancer and survival is dependent on age.

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Section: Discussionmentioning

confidence: 99%

Effect of age on the association between p16CDKN2A methylation and DNMT3B polymorphism in head and neck carcinoma and patient survival

Farias

Fraga²,

Oliveira³

et al. 2010

Int J Oncol

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show abstract

“…However, this strong positive prognostic factor is often confirmed in tonsillar and oropharyngeal carcinomas. Notably, the majority of studies that demonstrated increased survival were reporting on patients with oropharyngeal and/or tonsillar tumors Lindel et al, 2001;Sedaghat et al, 2009). The meta-analysis by Ragin et al examining the relationship between HPV and overall survival did not show any survival differences between HPV-positive and HPVnegative patients with cancer in non-oropharyngeal sites .…”

Section: Prognosis Of Hpv Positive Head and Neck Squamous Cell Carcinomamentioning

confidence: 99%

Human Papillomavirus and Related Diseases - From Bench to Bedside - A Clinical Perspective

Broeck¹

2012

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“…However, this strong positive prognostic factor is often confirmed in tonsillar and oropharyngeal carcinomas. Notably, the majority of studies that demonstrated increased survival were reporting on patients with oropharyngeal and/or tonsillar tumors (Ang et al, 2010;Lindel et al, 2001;Sedaghat et al, 2009). The meta-analysis by Ragin et al examining the relationship between HPV and overall survival did not show any survival differences between HPV-positive and HPVnegative patients with cancer in non-oropharyngeal sites .…”

Section: Prognosis Of Hpv Positive Head and Neck Squamous Cell Carcinomamentioning

confidence: 99%

Implications of Human Papillomavirus Infections in the Biology of Head and Neck Cancers

Descamps¹,

Duray²,

Philippe³

et al. 2012

Human Papillomavirus and Related Diseases - From Bench to Bedside - A Clinical Perspective

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Prognostic significance of human papillomavirus in oropharyngeal squamous cell carcinomas

Cited by 132 publications

References 25 publications

Effect of age on the association between p16CDKN2A methylation and DNMT3B polymorphism in head and neck carcinoma and patient survival

Effect of age on the association between p16CDKN2A methylation and DNMT3B polymorphism in head and neck carcinoma and patient survival

Human Papillomavirus and Related Diseases - From Bench to Bedside - A Clinical Perspective

Implications of Human Papillomavirus Infections in the Biology of Head and Neck Cancers

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