Prognostic significance of hyperfibrinogenemia in patients with esophageal squamous cell carcinoma

Suzuki, Takashi; Shimada, Hideaki; Nanami, Tatsuki; Oshima, Yoshiteru; Yajima, Satoshi; Washizawa, Naohiro; Kaneko, Hironori

doi:10.1007/s10147-016-1087-5

Cited by 9 publications

(5 citation statements)

References 21 publications

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“…The binding complex could induce epithelial–mesenchymal transition to promote invasion and metastasis of ESCC cell [ 24 ]. Moverover, hyperfibrinogenemia was observed not only in our study, but also reported by Suzuki et al [ 25 ] and Kijima et al [ 26 ], and preoperative circulating Fib was an independent prognostic factor for ESCC [ 27 ]. Hence, we observed that AFR was superior to Fib to predict the survival of the ESCC patients.…”

Section: Discussionsupporting

confidence: 87%

The predictive and prognostic role of a novel ADS score in esophageal squamous cell carcinoma patients undergoing esophagectomy

et al. 2018

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BackgroundChronic inflammation is deemed to play a significant effect on initiation and progression of esophageal squamous cell carcinoma (ESCC). In current study, we investigated the prognostic and predictive role of albumin (Alb) to fibrinogen (Fib) ratio (AFR) and a novel AFR–Alb-derived neutrophil/lymphocyte ratio (dNLR) score (ADS) in ESCC patients undergoing esophagectomy and compared them with Fib, Alb, neutrophil to lymphocyte ratio (NLR), dNLR, platelet to lymphocyte ratio (PLR) and lymphocyte to monocyte ratio (LMR).Materials and methodsA total of 153 clinical confirmed ESCC patients undergoing esophagectomy between January 2011 and December 2013 were included in present study. We detected preoperative Alb, Fib and neutrophil, monocyte, lymphocyte and platelet count, and obtained overall survival (OS) by 3 years’ follow-up in the cases. X-tile software, Kaplan–Meier curve, Cox regression and predicted nomogram were used to evaluate the predictive and prognostic role of them in ESCC patients.ResultsThe optimal cut-off values of Fib, Alb, AFR, NLR, dNLR, PLR and LMR were 3.2 mg/dL, 38.2 g/L, 9.3, 2.1, 4.3, 145.9 and 2.3, respectively. High levels of Fib [(adjusted hazard ratio (HR) = 2.148, 95% confidential interval (CI) (1.229–3.753)], dNLR (adjusted HR = 2.338, 95% CI 1.626–5.308) and PLR (adjusted HR = 1.964, 95% CI 1.129–3.415) as well as low AFR (adjusted HR = 2.381, 95% CI 1.152–4.926) and Alb (adjusted HR = 2.398, 95% CI 1.342–4.273) were significantly associated with decreased OS in ESCC patients. The survival predictive areas under the time-dependent receiver operating characteristics curve of AFR, dNLR and Alb were higher than Fib and PLR, respectively. High ADS score was significantly associated with short 3 years’ OS of ESCC patients (adjusted HR = 2.94, 95% CI 1.70–5.08). Moreover, OS of ESCC patients receiving adjuvant radio-chemotherapy was longer than those without the treatment in high ADS score subgroup (p = 0.001), however, no significant survival difference was observed in the patients with or without treatment radio-chemotherapy (p = 0.297). Additionally, a significant difference was observed in c-index values of the nomograms including or without ADS (0.720 vs. 0.670, p < 0.05).ConclusionsPreoperative ADS was a prospective biomarker to predict clinical efficacy of adjuvant radio-chemotherapy and clinical prognosis of ESCC patients undergoing esophagectomy, and the score could apparently improve predicted efficacy of the nomogram.Electronic supplementary materialThe online version of this article (10.1186/s12935-018-0648-2) contains supplementary material, which is available to authorized users.

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Section: Discussionsupporting

confidence: 87%

The predictive and prognostic role of a novel ADS score in esophageal squamous cell carcinoma patients undergoing esophagectomy

et al. 2018

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“…Finally, 43 articles (44 studies) with 17,510 patients were included in the present meta-analysis. 5,6,9,10,14,16,18-21,23,27–58…”

Section: Resultsmentioning

confidence: 99%

“…A total of 10 studies investigated the relationship between high fibrinogenemia and OS in ESCC. 5,16,18,23,27,34,39,49,52,57 A random-effects model was used to calculate the HR and 95% CI due to the severe heterogeneity (I 2 = 71%, P <0.001) among those studies. The pooled analysis indicated that fibrinogenemia was significantly related to a worse OS (HR 1.67; 95% CI 1.35, 2.07; P <0.001) (Supplement Figure 1).…”

Section: Resultsmentioning

confidence: 99%

Prognostic significance of pretreatment plasma fibrinogen level in patients with digestive system tumors: a meta-analysis

Ren

Bai

et al. 2018

Int J Biol Markers

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High pretreatment levels of plasma fibrinogen have been widely reported to be a potential predictor of prognosis in digestive system tumors; however, the conclusions are not consistent. Therefore, we performed a meta-analysis to comprehensively assess the prognostic roles of high pretreatment plasma fibrinogen levels in digestive system tumors. We searched for eligible studies in the PubMed, Embase, and Web of Science electronic databases for publications from the database inception to 1 September 2017. The endpoints of interest included overall survival, disease-free survival, and recurrence-free survival. We investigated the relationship between fibrinogenemia and overall survival in colorectal cancer (10 studies), gastric cancer (6), pancreatic cancer (6), hepatocellular carcinoma (7), and esophageal squamous cell carcinoma (10); the pooled results indicated that fibrinogenemia was significantly related to a worse overall survival (hazard ratio (HR) 1.73; 95% confidence interval (CI) 1.52, 1.97; P <0.001; HR 1.71; 95% CI 1.28, 2.28; P <0.001; HR 1.57; 95% CI 1.13, 2.17; P = 0.007; HR 1.89; 95% CI 1.57, 2.27; P <0.001, and HR 1.67; 95% CI 1.35, 2.07; P <0.001). Taken together, an increased pretreatment plasma fibrinogen level was related to worse survival in digestive system tumors, indicating that it could be a useful prognostic marker in these types of tumors.

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“…Further for AA, plasma level of fibrinogen was also increased in upper gastrointestinal related malignancies including of gastric and esophageal carcinoma. The marker was associated with poor prognosis in malignant condition [ [22] , [23] ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of plasma level of fibrinogen as a diagnostic criterion in acute appendicitis; cohort study

Shafagh

Davoodabadi

Gilasi

et al. 2022

Annals of Medicine &Amp; Surgery

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Prognostic significance of hyperfibrinogenemia in patients with esophageal squamous cell carcinoma

Cited by 9 publications

References 21 publications

The predictive and prognostic role of a novel ADS score in esophageal squamous cell carcinoma patients undergoing esophagectomy

The predictive and prognostic role of a novel ADS score in esophageal squamous cell carcinoma patients undergoing esophagectomy

Prognostic significance of pretreatment plasma fibrinogen level in patients with digestive system tumors: a meta-analysis

Evaluation of plasma level of fibrinogen as a diagnostic criterion in acute appendicitis; cohort study

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