Prognostic significance of Leu-M1 immunostaining in papillary carcinomas of the thyroid gland

Schröder, S.; Schwarz, Wolfgang; Rehpenning, W.; Löning, T.; Böcker, W.

doi:10.1007/bf00735224

Cited by 38 publications

(14 citation statements)

References 19 publications

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“…This difference is established on the detection of calcitonin, carcinoembrionic antigen, calcitonine gene related peptide, chromogranin A, Neuron-specific enolase, and other substances in medullary, but not in nonmedullary carcinomas [21,23,27]. In contrast, thyroglobulin, which is detected in papillary and follicular tumors, is hardly found in medullary carcinomas [19,21]. The follicular cells, from which the epithelial thyroid carcinomas arise, derive from the endotherm.…”

Section: Discussionmentioning

confidence: 99%

Blood group antigen expression in malignant tumors of the thryoid: a parallel between medullary and nonmedullary carcinomas

Larena

Vierbuchen

Fischer

1995

Langenbecks Arch Chir

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Blood group antigen (BGA) expression has been described in many fetal, adult, and tumorous tissues. Synthesis of BGA in the thyroid gland is regarded as oncofetal due to blood group structures that are detected in fetal and carcinomatous tissues but not in the normal adult organ. This study examined the prevalence of type 1 (CA-50, CA-19-9, Lea, Leb, A, B, H type 1) and type 2 (Le(x), Le(y), A, B, H type 2) antigens in normal thyroid (n = 25), papillary (n = 104), follicular (n = 52), anaplastic (n = 33), and medullary (n = 48) carcinomas of the thyroid. While normal thyroid tissue expressed no BGA, there was a significant increase of BGA expression in carcinomas of the thyroid gland. There are two theories about the possible origin of C cells, from which the medullary carcinomas arise. Some authors postulate that C cells belong to the amine precursor uptake and decarboxylation system and therefore derive from the neural crest, while others believe that C cells originate from the fifth pharyngeal pouch, as do the follicular cells. The results obtained in this study show that medullary and nonmedullary carcinomas correspond to one another in their BGA expression profile. Therefore it is concluded that medullary carcinomas may have the same origin as nonmedullary tumors of the thyroid.

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Section: Discussionmentioning

confidence: 99%

Blood group antigen expression in malignant tumors of the thryoid: a parallel between medullary and nonmedullary carcinomas

Larena

Vierbuchen

Fischer

1995

Langenbecks Arch Chir

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“…Schr6der et al hatten eine vermehrte Leu-M 1-Reaktivit~it mit einer signifikant schlechteren Prognose in Verbindung gebracht [38]. In der vorliegenden Arbeit wurde ebenfalls eine vermehrte Le X-Expression in Tumoren mit ausgedehnter lokaler Ausbreitung und sp~iterem Rezidiv nachgewiesen, jedoch nicht statistisch signifikant.…”

Section: Deletionunclassified

“…Das Auftreten bestimmter Blutgruppenstrukturen wird in Zusammenhang mit der F~ihigkeit der malignen Zellen zur Metastasierung und Invasion gesehen [19,31,42]. Schr6der et al [38] hatten eine vermehrte Reaktivitfit des Leu-M 1--AntikOrpers (Antik/3rper gegen Le x [16]) mit einer signifikant schlechteren Prognose des papillaren Schilddrtisenkarzinoms in Verbindung gebracht.…”

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Blutgruppenantigenexpression in papill�ren karzinomen der schilddr�se Eine immunhistochemische und klinische studie �ber das Vorkommen von Lewis-, AB0- und verwandten antigenen

Larena

Vierbuchen

Schröder

et al. 1996

Langenbecks Arch Chir

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Nine monoclonal antibodies, lectin from Ulex europaeus and neuraminidase enzyme were employed to demonstrate the occurrence of type 1 and type 2 blood group antigens in 104 cases of papillary carcinoma of the thyroid. The reagents applied, recognize the following blood group related antigens: CA-50 (sialylated type 1 precursor), CA-19-9 (sialylated Le(a)), Le(a), Le(b), A, B, H, Le(x), sialylated Le(x), and Le(y). Immunohistochemical studies revealed that papillary carcinoma of the thyroid, in contrast to histologically normal thyroid tissue, is characterised by a progressive expression of blood group antigens. Most tumours (84%) reacted with C-50 antibody, whereas only a minority of the tissues demonstrated the CA-19-9 antigen (38%). Type 2 structures Le(x) (47%) and Le(y) (13%) were found less often than their corresponding type 1 isomers Le(a) (71%) and Le(b) (62%). Desialylation with neuraminidase increased the Le(a) and Le(x) staining intensity in 27 and 44 case, respectively. Of the A, B, H antigens the A determinants encountered most frequently (24%). Comparative examinations of sequential sections of the same tumour revealed coexpression of type 1 antigens in the same areas. In carcinomas showing type 1 and type 2 antigen reactivity, a complementary distribution of the structures in different tumour areas was often demonstrated. Some tumours presented combined type 1 and type 2 antigen expression in the same cells, however, in distinct areas within the cell. A follow-up examination was carried out in 68 of the 104 cases. The observation time ranged from 12 to 217 months. Thirteen patients suffered from recurrence, of which 7 died. While lymphatic metastases occurred in 39 tumours, distant metastases were detected in 6 patients. Most of the recurrences were found in patients with tumour classification pT4 (n = 19), whereas none of the pT1 carcinomas (n = 20) showed recurrence. The clinical results were compared to the blood group antigen expression results. There was no correlation between antigen expression and differentiation degree of the tumour. The pT4 tumours showed a significant higher expression of the CA-50, CA-19-9, Le(a) and Sialyl Le(x) structures. Carcinomas expressing the Le(y) antigen were associated with a significant higher level of metastasizing capacity. The Le(y), H type 1 and H type 2 antigens occurred more frequently in recurrent tumours (n = 14). In contrast, none of the patients whose carcinomas expressed the A-antigens (n = 14) suffered from a recurrence or hematogenous metastasis. Multiple stepwise regression analysis was carried out to check the importance of each staining and clinical factor. In this analysis, "distant metastasis' was the most important parameter, whereas the staining results were of minor statistical importance.

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“…This latter study also reported that there was also less SSEA-1 immunoreactivity observed in follicular variant of papillary thyroid carcinomas (FVPTCs) (12). The presence of SSEA-1 reactivity has been suggested as an unfavorable prognostic sign in thyroid medullary and papillary carcinoma (13-16). …”

Section: Introductionmentioning

confidence: 99%

Stage-Specific Embryonic Antigen-1 (SSEA-1) Expression in Thyroid Tissues

Hardin

Zhang

et al. 2016

Endocr Pathol

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Stage specific embryonic antigen-1 (SSEA-1), also known as CD15, is a member of cluster of differentiation antigens that have been identified in various normal tissues and in different types of cancers including papillary and medullary thyroid carcinoma. SSEA-1 may be expressed in normal stem cells and cancer stem-like cells. To evaluate the potential diagnostic and prognostic utility of SSEA-1 in thyroid tumors, we analyzed the expression of SSEA-1 in normal and neoplastic thyroid tissues by immunohistochemistry (IHC) using a tissue microarray with 158 different tissue cores. To evaluate the potential utility of SSEA-1 as a surface marker, we also assessed the expression of SSEA-1 in thyroid cell lines by flow cytometric analysis. SSEA-1 immunoreactivity was identified in malignant thyroid follicular epithelial cancers but not in the benign thyroid tissues. Anaplastic thyroid (ATC) (80%) and conventional papillary thyroid carcinoma (PTC) (60.7%) showed significantly higher percentage of cases that were SSEA-1 immunoreactive than follicular variant of papillary thyroid carcinoma (FVPTC) (20.6%) and follicular carcinoma (FCA) (32.1%). Flow cytometric analysis of cultured thyroid cell lines showed that a small subpopulation of ATC and PTC thyroid tumor cells had SSEA-1 immunoreactivity which may represent thyroid cancer stem-like cells. The ATC cells expressed more SSEA-1 immunoreactive cells than the PTC cell lines. Our findings suggest that expression of SSEA-1 immunoreactivity in thyroid neoplasms was associated with more aggressive thyroid carcinomas. SSEA-1 is a marker that detects malignant thyroid neoplasms in formalin fixed-paraffin embedded thyroid tissue sections and may be a useful marker for thyroid cancer stem-like cells.

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Prognostic significance of Leu-M1 immunostaining in papillary carcinomas of the thyroid gland

Cited by 38 publications

References 19 publications

Blood group antigen expression in malignant tumors of the thryoid: a parallel between medullary and nonmedullary carcinomas

Blood group antigen expression in malignant tumors of the thryoid: a parallel between medullary and nonmedullary carcinomas

Blutgruppenantigenexpression in papill�ren karzinomen der schilddr�se Eine immunhistochemische und klinische studie �ber das Vorkommen von Lewis-, AB0- und verwandten antigenen

Stage-Specific Embryonic Antigen-1 (SSEA-1) Expression in Thyroid Tissues

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