Prognostic significance of lymph node metastasis in advanced carcinoma of the stomach

Kwon, Sung Joon; Kim, G. S.

doi:10.1002/bjs.1800831136

Cited by 82 publications

(50 citation statements)

References 5 publications

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“…Lymph node metastasis is one of the most significant prognostic indicators in patients with gastric cancer 22, 23. Therefore, it is important to accurately assess the presence or absence of lymph node metastasis in the clinical management of patients with gastric cancer.…”

Section: Intraoperative Diagnostic Technologies For Assessing Sn Metamentioning

confidence: 99%

Novel surgical approach based on the sentinel node concept in patients with early gastric cancer

Natsugoe

Arigami

Uenosono

et al. 2017

Annals of Gastroent Surgery

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Recent prospective multicenter trials have demonstrated the clinical safety and efficacy of sentinel node navigation surgery (SNNS) in patients with early gastric cancer. Further, development of an intraoperative imaging system and an indocyanine green fluorescence imaging approach has been attracting attention as a novel tool for detection of the sentinel node (SN). The greatest advantage of an in vivo imaging system is that it visualizes SN and afferent lymphatic vessels from the primary tumor site more clearly than the conventional dye approach. Besides visualization of the SN, it is also essential to accurately assess the presence or absence of lymph node metastasis in the intraoperative management of SNNS. However, the clinical significance of lymph node micrometastasis (LNM) in patients with gastric cancer remains controversial. Reverse transcription‐polymerase chain reaction (RT‐PCR) is one of the representative assays used to identify LNM. A rapid RT‐PCR assay that completes the detection of LNM within approximately 40 minutes has recently been produced and applied in the clinical management of SNNS. From the viewpoint of surgical methods, modified laparoscopic and endoscopic cooperative surgery with non‐exposed approaches has recently been highlighted as a promising technique to prevent tumor dissemination caused by surgical procedures, and is likely to be clinically applied to SNNS in the future. When carrying out SNNS as a minimally invasive surgery, it is important to consider the balance between post‐surgical quality of life and curability. Future prospective studies on SNNS will greatly contribute to furthering its establishment as a beneficial procedure for patients with early gastric cancer.

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Section: Intraoperative Diagnostic Technologies For Assessing Sn Metamentioning

confidence: 99%

Novel surgical approach based on the sentinel node concept in patients with early gastric cancer

Natsugoe

Arigami

Uenosono

et al. 2017

Annals of Gastroent Surgery

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“…Lymph node metastasis is one of the most important prognostic factors in patients with gastric cancer (Kwon and Kim, 1996;Nitti et al, 2003). Therefore, radical lymphadenectomy for gastric cancer has become a standard procedure, resulting in the long-term survival of patients with lymph node metastasis (Maehara et al, 1992).…”

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confidence: 99%

Lymphatic invasion using D2-40 monoclonal antibody and its relationship to lymph node micrometastasis in pN0 gastric cancer

et al. 2005

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The monoclonal antibody D2-40 is a specific lymphatic endothelial markers and D2-40 staining have been applicable to evaluate lymphatic invasion in various malignant neoplasms. In the present study, we investigated lymph node micrometastasis determined by immunohistochemistry (IHC) and reverse transcription -polymerase chain reaction (RT -PCR) in all dissected lymph nodes obtained from 80 patients with node-negative gastric cancer, and analysed the relationship between micrometastasis and clinicopathological findings including lymphatic invasion of the resected primary tumour using D2-40 immunohistochemical staining. The incidence of micrometastasis determined by IHC and RT -PCR was 11.3% (nine out of 80) and 31.3% (25 out of 80), respectively. Although haematoxylin -eosin (HE) staining revealed lymphatic invasion in 11.3% (nine out of 80) of patients, D2-40 staining uncovered new invasion in 23.8% (19 out of 80) of patients. In the diagnosis of HE and D2-40 staining, the incidence of micrometastasis was significantly higher in patients with lymphatic invasion than in those without lymphatic invasion (P ¼ 0.0150 and Po0.0001, respectively). Micrometastasis correlated more closely with D2-40 than with HE staining. We demonstrated a high incidence of micrometastasis and lymphatic invasion and a correlation between them even in pN0 gastric cancer. When planning less invasive treatment, the presence of such occult cancer cells should be considered.

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“…İlk defa gastrik kanserde araştırıl-mış ve lenf nodu tutulumu olan mide kanserli hastaların bazı subgruplarında önemli bir prognostik faktör olduğu gösterilmiştir (11). Takip eden dönemde özefagus, pankreas, meme, mesane kanserinde LNR'nin klinik kullanımı araştırılmış fakat şu ana kadar elde edilen bilgilere göre N evresine alternatif olabilirliği göste-rilememiştir (11,(33)(34)(35)(36). LNR ve sağkalım arasındaki ilişki kolorektal kanserde ilk kez Berger ve ark.…”

Section: Discussionunclassified

“…Metastatik lenf nodlarının çıkarılan lenf nodlarına oranı (LNR) ilk defa gastrik kanserde araştırılmış ve lenf nodu tutulumu olan mide kanserli hastaların bazı subgruplarında önemli bir prognostik faktör olduğu gösterilmiştir (11). Takip eden yıllarda kolorektal kanserli hastalarda da LNR'nin prognostik önemini ortaya koyan çalışmalar yapılmıştır (12,13).…”

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Relationship of Lymph Node Ratio, Standard Prognostic Factors and Survival in Patients with Colorectal Cancer

İlgün¹,

Yıldırım²,

Şit³

et al. 2013

JAREM

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ÖZETAmaç: Kolorektal kanserli hastalarda, standart faktörlerin yanı sıra, tutulu lenf nodlarının çıkarılan lenf nodlarına oranının (LNR), sağkalımla olan ilişki-sinin belirlenmesi hedeflenmiştir.Yöntemler: Ocak 2003-Mart 2010 yılları arasında kolorektal kanser nedeniyle ameliyat edilen ve istenen kriterleri sağlayan 72 hastanın dosyaları, T, N ve M durumu ve evreleri, lenfovasküler ve perinöral invazyon varlığı, çıkarılan lenf nodu sayısı, tutulu lenf nodu sayısı, lenf nodu kapsül invazyonu varlığı ve LNR açısından incelenmiş ve bu parametrelerin sağkalımla ilişkileri retrospektif olarak araştırılmıştır.Bulgular: Kolorektal kanserli hastaların sağkalımlarıyla, LNR, lenf nodu evresi, tutulu lenf nodu sayısı, TNM evresi, PNI ve lenf nodu kapsül invazyonu varlığının korelasyon gösterdiği belirlenmiştir.Sonuç: LNR ve lenf nodu evresi, incelenen parametreler arasında sağkalımla en yüksek ilişkili parametreler olarak bulunmuştur. (JAREM 2013; 3: 14-8) Anahtar Sözcükler: Kolorektal kanser, lenf nodu oranı, sağkalım, prognoz ABSTRACT Objective: The aim of our study is to investigate the relationship between overall survival and lymph node ratio (the number of positive lymph nodes divided by total number of lymph nodes) (LNR) as well as other standard prognostic factors in patients who underwent surgery for colorectal cancer.Methods: A retrospective study was performed to analyse the data collected for 72 patients who underwent surgery with the diagnosis of colorectal cancer from January 2003 to March 2010. The variables such as T, N and M stage, lymphovascular and perineural invasion, number of retrived lymph nodes, number of metastatic lymph nodes, lymph node capsule invasion, LNR and their effects on overall survival were analysed.Results: LNR, lymph node stage, number of metastatic lymph nodes, TNM stage, perineural invasion and lymph node capsule invasion had significant effects on overall survival.Conclusion: LNR and lymph node stage were the most significant variables associated with overall survival. (JAREM 2013; 3: 14-8)

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Prognostic significance of lymph node metastasis in advanced carcinoma of the stomach

Cited by 82 publications

References 5 publications

Novel surgical approach based on the sentinel node concept in patients with early gastric cancer

Novel surgical approach based on the sentinel node concept in patients with early gastric cancer

Lymphatic invasion using D2-40 monoclonal antibody and its relationship to lymph node micrometastasis in pN0 gastric cancer

Relationship of Lymph Node Ratio, Standard Prognostic Factors and Survival in Patients with Colorectal Cancer

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