Prognostic Significance of Lymph Node Metastases and Ratio in Esophageal Cancer

Wilson, Matthew Z.; Rosato, Ernest L.; Chojnacki, Karen A.; Chervoneva, Inna; Kairys, John C.; Cohn, Herbert E.; Rosato, Francis E.; Berger, Adam C.

doi:10.1016/j.jss.2007.07.028

Cited by 86 publications

(57 citation statements)

References 13 publications

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“…These modifications reflect findings which show improved prognostic stratification with consideration of the number ofdiseased lymph nodes [13,[84][85][86]. Several studies have shown the number of positive lymph nodes to be an independent prognostic indicator [13,14,[87][88][89][90].…”

Section: Number Of Positive Lymph Nodesmentioning

confidence: 56%

Lymph node metastases and prognosis in oesophageal carcinoma – A systematic review

Kayani

Zacharakis

Ahmed

et al. 2011

European Journal of Surgical Oncology (EJSO)

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Oesophageal cancer is the seventh most common cause of cancer-related death in the developed world and the incidence of oesophageal adenocarcinoma is now the fastest growing of any gastrointestinal cancer. Lymph node involvement is the single most important prognostic factor in oesophageal cancer. Imaging to determine the extent of lymph node involvement and plan treatment often requires a combination of modalities to avoid under-staging. The seventh edition of the staging system released by the International Union Against Cancer (IUCC) has stratified lymph node involvement according to the number of lymph nodes involved and redefined its groupings for location of metastatic lymph node involvement. This review discusses the prognostic and treatment implications of these modifications and explores micrometastatic lymph node involvement, capsular infiltration and lymph node ratio as possible additions to the staging system.

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Section: Number Of Positive Lymph Nodesmentioning

confidence: 56%

Lymph node metastases and prognosis in oesophageal carcinoma – A systematic review

Kayani

Zacharakis

Ahmed

et al. 2011

European Journal of Surgical Oncology (EJSO)

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Section: Introductionmentioning

confidence: 99%

“…More than 65% of patients with localized esophageal cancers and negative resection margin have a positive lymph node at the time of surgery [1]. However, despite complete tumor resection and extensive lymphadenectomy, systemic and local recurrence is common [2] and the five-year survival rate is 15-39% [3].The discovery over the last decade of markers of lymphatic endothelial cells like podoplanin (D2-40) [4], LYVE-1 [5] and Prox 1 [6], and the development of novel antibodies to these markers, have generated …”

mentioning

confidence: 99%

Lymphatic vessel invasion detected by the endothelial lymphatic marker D2-40 (podoplanin) is predictive of regional lymph node status and an independent prognostic factor in patients with resected esophageal cancer

Kozłowski¹,

Naumnik²,

Nikliński³

et al. 2011

Folia Histochem Cytobiol.

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Abstract:The discovery of markers to lymphatic endothelial cells and the development of novel antibodies to these markers have brought increasing attention to the lymphatics and progress in the understanding of lymphangiogenesis and cancer metastasis. In this study, we investigate the presence of lymphatic vessel invasion (LVI) detected by D2-40 immunohistochemical staining in resected esophageal cancer and correlated with clinicopathologic data and patient survival. Sixty nine patients, who had a primary resection of esophageal cancer, were analyzed by univariate and multivariate logistic regression, and univariate and multivariate survival analysis. The total rate of LVI was 72% (50/69). Positive LVI was significantly correlated with lymph node metastasis (p < 0.001), tumor size (p < 0.001), histological grading (p = 0.017), tumor depth (p = 0.001), and stage (p < 0.001). Multivariate logistic analysis identified LVI (p = 0.036) as a predictor of regional lymph node metastasis. On univariate survival analysis, patients with LVI had a significantly shorter disease-free survival, cancer-specific survival and overall survival. Multivariate analysis proved that LVI diagnosed by D2-40 is an independent prognostic factor of both disease-free survival (p = 0.04) and overall survival (p = 0.032) in resected esophageal cancer. These results show that LVI assessment identifies patients at high risk for regional lymph node metastasis and that LVI is an independent prognostic factor in patients with esophageal cancer. (Folia Histochemica et Cytobiologica 2011; Vol. 49, No. 1, pp. 90-97) Key words: esophageal cancer, lymphatic vessel invasion, podoplanin, D2-40, lymph node metastasis, prognosis ageal cancer. More than 65% of patients with localized esophageal cancers and negative resection margin have a positive lymph node at the time of surgery [1]. However, despite complete tumor resection and extensive lymphadenectomy, systemic and local recurrence is common [2] and the five-year survival rate is 15-39% [3].The discovery over the last decade of markers of lymphatic endothelial cells like podoplanin (D2-40) [4], LYVE-1 [5] and Prox 1 [6], and the development of novel antibodies to these markers, have generated

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“…In many human cancers, metastasis to the regional lymph node is one of the most significant predictors of patient outcome (8,9). Lymph node metastasis is associated with decreased papillary thyroid carcinoma survival and increased risk of local recurrence.…”

Section: ) In Addition High Sphingosine Kinase 1 Expression Was mentioning

confidence: 99%

Predictive Value of Sphingosine Kinase 1 Expression in Papillary Thyroid Carcinoma

Kim

et al. 2017

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Prognostic Significance of Lymph Node Metastases and Ratio in Esophageal Cancer

Abstract: Background-The incidence of carcinoma of the distal esophagus and GE junction is rapidly increasing. A large single-center experience was reviewed to determine the impact of lymph node positivity and ratio on survival.

Cited by 86 publications

References 13 publications

Lymph node metastases and prognosis in oesophageal carcinoma – A systematic review

Lymph node metastases and prognosis in oesophageal carcinoma – A systematic review

Lymphatic vessel invasion detected by the endothelial lymphatic marker D2-40 (podoplanin) is predictive of regional lymph node status and an independent prognostic factor in patients with resected esophageal cancer

Predictive Value of Sphingosine Kinase 1 Expression in Papillary Thyroid Carcinoma

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